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Crystallography, X-Ray

  • 1.
    Burton A, Hamza G, Zhang A, Muir T. Chemical biology approaches to study histone interactors. Biochem Soc Trans. 2021;49(5):2431–2441. PMCID: PMC9785950
    Reference Link
  • 1.
    Jimah J, Salinas N, Sala-Rabanal M, Jones N, Sibley D, Nichols C, Schlesinger P, Tolia N. Malaria parasite CelTOS targets the inner leaflet of cell membranes for pore-dependent disruption. Elife. 2016;5. PMCID: PMC5132341
    Reference Link
  • 1.
    Huang J, Yuan Y, Zhao N, Pu D, Tang Q, Zhang S, Luo S, Yang X, Wang N, Xiao Y, Zhang T, Liu Z, Sakata-Kato T, Jiang X, Kato N, Yan N, Yin H. Orthosteric-allosteric dual inhibitors of PfHT1 as selective antimalarial agents. Proc Natl Acad Sci U S A. 2021;118(3). PMCID: PMC7826358
    Reference Link
  • 1.
    Travis S, DAmico K, Yu I-M, McMahon C, Hamid S, Ramirez-Arellano G, Jeffrey P, Hughson F. Structural basis for the binding of SNAREs to the multisubunit tethering complex Dsl1. J Biol Chem. 2020;295(30):10125–10135. PMCID: PMC7383367
    Reference Link
  • 1.
    Seyedsayamdost M, Stallforth P. Special Issue in Honor of Professor Jon Clardy. J Nat Prod. 2020;83(3):565–568. PMID: 32216264
    Reference Link
  • 1.
    Huang X, Duddy O, Silpe J, Paczkowski J, Cong J, Henke B, Bassler B. Mechanism underlying autoinducer recognition in the DPO-VqmA quorum-sensing pathway. J Biol Chem. 2020;295(10):2916–2931. PMCID: PMC7062168
    Reference Link
  • 1.
    Travis S, Kokona B, Fairman R, Hughson F. Roles of singleton tryptophan motifs in COPI coat stability and vesicle tethering. Proc Natl Acad Sci U S A. 2019;116(48):24031–24040. PMCID: PMC6883825
    Reference Link
  • 1.
    Taylor C, Cormier K, Keenan S, Earnest S, Stippec S, Wichaidit C, Juang Y-C, Wang J, Shvartsman S, Goldsmith E, Cobb M. Functional divergence caused by mutations in an energetic hotspot in ERK2. Proc Natl Acad Sci U S A. 2019;116(31):15514–15523. PMCID: PMC6681740
    Reference Link
  • 1.
    Brown A, Chua N, Yan N. The shape of human squalene epoxidase expands the arsenal against cancer. Nat Commun. 2019;10(1):888. PMCID: PMC6384927
    Reference Link
  • 1.
    Davis K, Schramma K, Hansen W, Bacik J, Khare S, Seyedsayamdost M, Ando N. Structures of the peptide-modifying radical SAM enzyme SuiB elucidate the basis of substrate recognition. Proc Natl Acad Sci U S A. 2017;114(39):10420–10425. PMCID: PMC5625900
    Reference Link
  • 1.
    Wang R, Seyedsayamdost M. Roseochelin B, an Algaecidal Natural Product Synthesized by the Roseobacter Phaeobacter inhibens in Response to Algal Sinapic Acid. Org Lett. 2017;19(19):5138–5141. PMID: 28920692
    Reference Link
  • 1.
    Degtjarik O, Brynda J, Ettrichova O, Kuty M, Sinha D, Smatanova I, Carey J, Ettrich R, Řeha D. Quantum Calculations Indicate Effective Electron Transfer between FMN and Benzoquinone in a New Crystal Structure of Escherichia coli WrbA. J Phys Chem B. 2016;120(22):4867–77. PMID: 27183467
    Reference Link
  • 1.
    Yin P, Fan H, Hao Q, Yuan X, Wu D, Pang Y, Yan C, Li W, Wang J, Yan N. Structural insights into the mechanism of abscisic acid signaling by PYL proteins. Nat Struct Mol Biol. 2009;16(12):1230–6. PMID: 19893533
    Reference Link
  • 1.
    Wang Y, Huang Y, Wang J, Cheng C, Huang W, Lu P, Xu Y-N, Wang P, Yan N, Shi Y. Structure of the formate transporter FocA reveals a pentameric aquaporin-like channel. Nature. 2009;462(7272):467–72. PMID: 19940917
    Reference Link
  • 1.
    Qi S, Pang Y, Hu Q, Liu Q, Li H, Zhou Y, He T, Liang Q, Liu Y, Yuan X, Luo G, Li H, Wang J, Yan N, Shi Y. Crystal structure of the Caenorhabditis elegans apoptosome reveals an octameric assembly of CED-4. Cell. 2010;141(3):446–57. PMID: 20434985
    Reference Link
  • 1.
    Hao Q, Yin P, Yan C, Yuan X, Li W, Zhang Z, Liu L, Wang J, Yan N. Functional mechanism of the abscisic acid agonist pyrabactin. J Biol Chem. 2010;285(37):28946–52. PMCID: PMC2937921
    Reference Link
  • 1.
    Yuan X, Yin P, Hao Q, Yan C, Wang J, Yan N. Single amino acid alteration between valine and isoleucine determines the distinct pyrabactin selectivity by PYL1 and PYL2. J Biol Chem. 2010;285(37):28953–8. PMCID: PMC2937922
    Reference Link
  • 1.
    Dang S, Sun L, Huang Y, Lu F, Liu Y, Gong H, Wang J, Yan N. Structure of a fucose transporter in an outward-open conformation. Nature. 2010;467(7316):734–8. PMID: 20877283
    Reference Link
  • 1.
    Lu F, Li S, Jiang Y, Jiang J, Fan H, Lu G, Deng D, Dang S, Zhang X, Wang J, Yan N. Structure and mechanism of the uracil transporter UraA. Nature. 2011;472(7342):243–6. PMID: 21423164
    Reference Link
  • 1.
    Xie T, Ren R, Zhang Y- yuan, Pang Y, Yan C, Gong X, He Y, Li W, Miao D, Hao Q, Deng H, Wang Z, Wu J-W, Yan N. Molecular mechanism for inhibition of a critical component in the Arabidopsis thaliana abscisic acid signal transduction pathways, SnRK2.6, by protein phosphatase ABI1. J Biol Chem. 2012;287(1):794–802. PMCID: PMC3249133
    Reference Link
  • 1.
    Deng D, Yan C, Pan X, Mahfouz M, Wang J, Zhu J-K, Shi Y, Yan N. Structural basis for sequence-specific recognition of DNA by TAL effectors. Science. 2012;335(6069):720–3. PMCID: PMC3586824
    Reference Link
  • 1.
    Zhang X, Ren W, DeCaen P, Yan C, Tao X, Tang L, Wang J, Hasegawa K, Kumasaka T, He J, Wang J, Clapham D, Yan N. Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel. Nature. 2012;486(7401):130–4. PMCID: PMC3979295
    Reference Link
  • 1.
    Sugihara J, Sun L, Yan N, Kaback R. Dynamics of the L-fucose/H+ symporter revealed by fluorescence spectroscopy. Proc Natl Acad Sci U S A. 2012;109(37):14847–51. PMCID: PMC3443143
    Reference Link
  • 1.
    Deng D, Yin P, Yan C, Pan X, Gong X, Qi S, Xie T, Mahfouz M, Zhu J-K, Yan N, Shi Y. Recognition of methylated DNA by TAL effectors. Cell Res. 2012;22(10):1502–4. PMCID: PMC3463267
    Reference Link
  • 1.
    Yin P, Deng D, Yan C, Pan X, Xi J, Yan N, Shi Y. Specific DNA-RNA hybrid recognition by TAL effectors. Cell Rep. 2012;2(4):707–13. PMID: 23022487
    Reference Link
  • 1.
    Sun L, Zeng X, Yan C, Sun X, Gong X, Rao Y, Yan N. Crystal structure of a bacterial homologue of glucose transporters GLUT1-4. Nature. 2012;490(7420):361–6. PMID: 23075985
    Reference Link
  • 1.
    Madej G, Dang S, Yan N, Kaback R. Evolutionary mix-and-match with MFS transporters. Proc Natl Acad Sci U S A. 2013;110(15):5870–4. PMCID: PMC3625355
    Reference Link
  • 1.
    Yin P, Li Q, Yan C, Liu Y, Liu J, Yu F, Wang Z, Long J, He J, Wang H-W, Wang J, Zhu J-K, Shi Y, Yan N. Structural basis for the modular recognition of single-stranded RNA by PPR proteins. Nature. 2013;504(7478):168–71. PMID: 24162847
    Reference Link
  • 1.
    Li W, Wang L, Sheng X, Yan C, Zhou R, Hang J, Yin P, Yan N. Molecular basis for the selective and ABA-independent inhibition of PP2CA by PYL13. Cell Res. 2013;23(12):1369–79. PMCID: PMC3847573
    Reference Link
  • 1.
    Deng D, Xu C, Sun P, Wu J, Yan C, Hu M, Yan N. Crystal structure of the human glucose transporter GLUT1. Nature. 2014;510(7503):121–5. PMID: 24847886
    Reference Link
  • 1.
    Wang J, Yan C, Li Y, Hirata K, Yamamoto M, Yan N, Hu Q. Crystal structure of a bacterial homologue of SWEET transporters. Cell Res. 2014;24(12):1486–9. PMCID: PMC4260346
    Reference Link
  • 1.
    Gong X, Li J, Shao W, Wu J, Qian H, Ren R, Espenshade P, Yan N. Structure of the WD40 domain of SCAP from fission yeast reveals the molecular basis for SREBP recognition. Cell Res. 2015;25(4):401–11. PMCID: PMC4387560
    Reference Link
  • 1.
    Yan N. Structural Biology of the Major Facilitator Superfamily Transporters. Annu Rev Biophys. 2015;44:257–83. PMID: 26098515
    Reference Link
  • 1.
    Ren R, Zhou X, He Y, Ke M, Wu J, Liu X, Yan C, Wu Y, Gong X, Lei X, Yan F, Radhakrishnan A, Yan N. PROTEIN STRUCTURE. Crystal structure of a mycobacterial Insig homolog provides insight into how these sensors monitor sterol levels. Science. 2015;349(6244):187–91. PMCID: PMC4704858
    Reference Link
  • 1.
    Deng D, Sun P, Yan C, Ke M, Jiang X, Xiong L, Ren W, Hirata K, Yamamoto M, Fan S, Yan N. Molecular basis of ligand recognition and transport by glucose transporters. Nature. 2015;526(7573):391–6. PMID: 26176916
    Reference Link
  • 1.
    Jiang X, Smirnova I, Kasho V, Wu J, Hirata K, Ke M, Pardon E, Steyaert J, Yan N, Kaback R. Crystal structure of a LacY-nanobody complex in a periplasmic-open conformation. Proc Natl Acad Sci U S A. 2016;113(44):12420–12425. PMCID: PMC5098631
    Reference Link
  • 1.
    Gong X, Qian H, Shao W, Li J, Wu J, Liu J-J, Li W, Wang H-W, Espenshade P, Yan N. Complex structure of the fission yeast SREBP-SCAP binding domains reveals an oligomeric organization. Cell Res. 2016;26(11):1197–1211. PMCID: PMC5099872
    Reference Link
  • 1.
    Jindal G, Goyal Y, Humphreys J, Yeung E, Tian K, Patterson V, He H, Burdine R, Goldsmith E, Shvartsman S. How activating mutations affect MEK1 regulation and function. J Biol Chem. 2017;292(46):18814–18820. PMCID: PMC5704466
    Reference Link
  • 1.
    Lynch E, Hicks D, Shepherd M, Endrizzi J, Maker A, Hansen J, Barry R, Gitai Z, Baldwin E, Kollman J. Human CTP synthase filament structure reveals the active enzyme conformation. Nat Struct Mol Biol. 2017;24(6):507–514. PMCID: PMC5472220
    Reference Link
  • 1.
    Boyaci H, Shah T, Hurley A, Kokona B, Li Z, Ventocilla C, Jeffrey P, Semmelhack M, Fairman R, Bassler B, Hughson F. Structure, Regulation, and Inhibition of the Quorum-Sensing Signal Integrator LuxO. PLoS Biol. 2016;14(5):e1002464. PMCID: PMC4878744
    Reference Link
  • 1.
    Jenni S, Goyal Y, von Grotthuss M, Shvartsman S, Klein D. Structural Basis of Neurohormone Perception by the Receptor Tyrosine Kinase Torso. Mol Cell. 2015;60(6):941–52. PMID: 26698662
    Reference Link
  • 1.
    Seyedsayamdost M, Case R, Kolter R, Clardy J. The Jekyll-and-Hyde chemistry of Phaeobacter gallaeciensis. Nat Chem. 2011;3(4):331–5. PMCID: PMC3376411
    Reference Link
  • 1.
    Seyedsayamdost M, Traxler M, Zheng S-L, Kolter R, Clardy J. Structure and biosynthesis of amychelin, an unusual mixed-ligand siderophore from Amycolatopsis sp. AA4. J Am Chem Soc. 2011;133(30):11434–7. PMCID: PMC3144690
    Reference Link
  • 1.
    Maksimov M, Koos J, Zong C, Lisko B, Link J. Elucidating the Specificity Determinants of the AtxE2 Lasso Peptide Isopeptidase. J Biol Chem. 2015;290(52):30806–12. PMCID: PMC4692210
    Reference Link
  • 1.
    Cosgrove M, Bever K, Avalos J, Muhammad S, Zhang X, Wolberger C. The structural basis of sirtuin substrate affinity. Biochemistry. 2006;45(24):7511–21. PMID: 16768447
    Reference Link
  • 1.
    Hoff K, Avalos J, Sens K, Wolberger C. Insights into the sirtuin mechanism from ternary complexes containing NAD+ and acetylated peptide. Structure. 2006;14(8):1231–40. PMID: 16905097
    Reference Link
  • 1.
    Tao X, Avalos J, Chen J, MacKinnon R. Crystal structure of the eukaryotic strong inward-rectifier K+ channel Kir2.2 at 3.1 A resolution. Science. 2009;326(5960):1668–74. PMCID: PMC2819303
    Reference Link
  • 1.
    Williams B, Van Benschoten A, Cimermancic P, Donia M, Zimmermann M, Taketani M, Ishihara A, Kashyap P, Fraser J, Fischbach M. Discovery and characterization of gut microbiota decarboxylases that can produce the neurotransmitter tryptamine. Cell Host Microbe. 2014;16(4):495–503. PMCID: PMC4260654
    Reference Link
  • 1.
    Ha J, Pokrovskaya I, Climer L, Shimamura G, Kudlyk T, Jeffrey P, Lupashin V, Hughson F. Cog5-Cog7 crystal structure reveals interactions essential for the function of a multisubunit tethering complex. Proc Natl Acad Sci U S A. 2014;111(44):15762–7. PMCID: PMC4226102
    Reference Link
  • 1.
    Baker R, Jeffrey P, Zick M, Phillips B, Wickner W, Hughson F. A direct role for the Sec1/Munc18-family protein Vps33 as a template for SNARE assembly. Science. 2015;349(6252):1111–4. PMCID: PMC4727825
    Reference Link

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