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Cryoelectron Microscopy

  • 1.
    Yuan Y, Kong F, Xu H, Zhu A, Yan N, Yan C. Cryo-EM structure of human glucose transporter GLUT4. Nat Commun. 2022;13(1):2671. PMCID: PMC9106701
    Reference Link
  • 1.
    Toti K, Jimah J, Salmaso V, Hinshaw J, Jacobson K. Synthesis and Effect of Conformationally Locked Carbocyclic Guanine Nucleotides on Dynamin. Biomolecules. 2022;12(4). PMCID: PMC9031165
    Reference Link
  • 1.
    Doyle M, Jimah J, Dowdy T, Ohlemacher S, Larion M, Hinshaw J, Bernstein H. Cryo-EM structures reveal multiple stages of bacterial outer membrane protein folding. Cell. 2022;185(7):1143–1156.e13. PMCID: PMC8985213
    Reference Link
  • 1.
    Sochacki K, Heine B, Haber G, Jimah J, Prasai B, Alfonzo-Méndez M, Roberts A, Somasundaram A, Hinshaw J, Taraska J. The structure and spontaneous curvature of clathrin lattices at the plasma membrane. Dev Cell. 2021;56(8):1131–1146.e3. PMCID: PMC8081270
    Reference Link
  • 1.
    Gao S, Yao X, Yan N. Structure of human Ca2.2 channel blocked by the painkiller ziconotide. Nature. 2021;596(7870):143–147. PMCID: PMC8529174
    Reference Link
  • 1.
    Shen H, Yan N, Pan X. Structural determination of human Na1.4 and Na1.7 using single particle cryo-electron microscopy. Methods Enzymol. 2021;653:103–120. PMID: 34099168
    Reference Link
  • 1.
    Li Z, Jin X, Wu T, Huang G, Wu K, Lei J, Pan X, Yan N. Structural Basis for Pore Blockade of the Human Cardiac Sodium Channel Na 1.5 by the Antiarrhythmic Drug Quinidine*. Angew Chem Int Ed Engl. 2021;60(20):11474–11480. PMID: 33684260
    Reference Link
  • 1.
    Li Z, Jin X, Wu T, Zhao X, Wang W, Lei J, Pan X, Yan N. Structure of human Na1.5 reveals the fast inactivation-related segments as a mutational hotspot for the long QT syndrome. Proc Natl Acad Sci U S A. 2021;118(11). PMCID: PMC7980460
    Reference Link
  • 1.
    Pan X, Li Z, Jin X, Zhao Y, Huang G, Huang X, Shen Z, Cao Y, Dong M, Lei J, Yan N. Comparative structural analysis of human Na1.1 and Na1.5 reveals mutational hotspots for sodium channelopathies. Proc Natl Acad Sci U S A. 2021;118(11). PMCID: PMC7980448
    Reference Link
  • 1.
    Yan R, Cao P, Song W, Qian H, Du X, Coates H, Zhao X, Li Y, Gao S, Gong X, Liu X, Sui J, Lei J, Yang H, Brown A, Zhou Q, Yan C, Yan N. A structure of human Scap bound to Insig-2 suggests how their interaction is regulated by sterols. Science. 2021;371(6533). PMID: 33446483
    Reference Link
  • 1.
    Gong D, Yan N, Ledford H. Structural Basis for the Modulation of Ryanodine Receptors. Trends Biochem Sci. 2021;46(6):489–501. PMID: 33353849
    Reference Link
  • 1.
    Pan Y, Ren Z, Gao S, Shen J, Wang L, Xu Z, Yu Y, Bachina P, Zhang H, Fan X, Laganowsky A, Yan N, Zhou M. Structural basis of ion transport and inhibition in ferroportin. Nat Commun. 2020;11(1):5686. PMCID: PMC7655804
    Reference Link
  • 1.
    Gao S, Yan N. Structural Basis of the Modulation of the Voltage-Gated Calcium Ion Channel Ca 1.1 by Dihydropyridine Compounds*. Angew Chem Int Ed Engl. 2021;60(6):3131–3137. PMCID: PMC7898392
    Reference Link
  • 1.
    Yao X, Fan X, Yan N. Cryo-EM analysis of a membrane protein embedded in the liposome. Proc Natl Acad Sci U S A. 2020;117(31):18497–18503. PMCID: PMC7414195
    Reference Link
  • 1.
    Gao S, Valinsky W, On N, Houlihan P, Qu Q, Liu L, Pan X, Clapham D, Yan N. Employing NaChBac for cryo-EM analysis of toxin action on voltage-gated Na channels in nanodisc. Proc Natl Acad Sci U S A. 2020;117(25):14187–14193. PMCID: PMC7322032
    Reference Link
  • 1.
    Wang L, Qian H, Nian Y, Han Y, Ren Z, Zhang H, Hu L, Prasad B, Laganowsky A, Yan N, Zhou M. Structure and mechanism of human diacylglycerol O-acyltransferase 1. Nature. 2020;581(7808):329–332. PMCID: PMC7255049
    Reference Link
  • 1.
    Qian H, Zhao X, Yan R, Yao X, Gao S, Sun X, Du X, Yang H, Wong C, Yan N. Structural basis for catalysis and substrate specificity of human ACAT1. Nature. 2020;581(7808):333–338. PMCID: 5093084
    Reference Link
  • 1.
    Zhao Y, Huang G, Wu J, Wu Q, Gao S, Yan Z, Lei J, Yan N. Molecular Basis for Ligand Modulation of a Mammalian Voltage-Gated Ca Channel. Cell. 2019;177(6):1495–1506.e12. PMID: 31150622
    Reference Link
  • 1.
    Chi X, Gong D, Ren K, Zhou G, Huang G, Lei J, Zhou Q, Yan N. Molecular basis for allosteric regulation of the type 2 ryanodine receptor channel gating by key modulators. Proc Natl Acad Sci U S A. 2019;116(51):25575–25582. PMCID: PMC6926060
    Reference Link
  • 1.
    Zhao Y, Huang G, Wu Q, Wu K, Li R, Lei J, Pan X, Yan N. Cryo-EM structures of apo and antagonist-bound human Ca3.1. Nature. 2019;576(7787):492–497. PMCID: 18083096
    Reference Link
  • 1.
    Brose N, Brunger A, Cafiso D, Chapman E, Diao J, Hughson F, Jackson M, Jahn R, Lindau M, Ma C, Rizo J, Shin Y-K, Söllner T, Tamm L, Yoon T-Y, Zhang Y. Synaptic vesicle fusion: today and beyond. Nat Struct Mol Biol. 2019;26(8):663–668. PMID: 31384060
    Reference Link
  • 1.
    Gong D, Chi X, Wei J, Zhou G, Huang G, Zhang L, Wang R, Lei J, Chen S, Yan N. Modulation of cardiac ryanodine receptor 2 by calmodulin. Nature. 2019;572(7769):347–351. PMID: 31278385
    Reference Link
  • 1.
    Qian H, Cao P, Hu M, Gao S, Yan N, Gong X. Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm. Nat Commun. 2019;10(1):2320. PMCID: PMC6534611
    Reference Link
  • 1.
    Shen H, Liu D, Wu K, Lei J, Yan N. Structures of human Na1.7 channel in complex with auxiliary subunits and animal toxins. Science. 2019;363(6433):1303–1308. PMID: 30765606
    Reference Link
  • 1.
    Pan X, Li Z, Huang X, Huang G, Gao S, Shen H, Liu L, Lei J, Yan N. Molecular basis for pore blockade of human Na channel Na1.2 by the μ-conotoxin KIIIA. Science. 2019;363(6433):1309–1313. PMID: 30765605
    Reference Link
  • 1.
    Yan R, Qian H, Lukmantara I, Gao M, Du X, Yan N, Yang H. Human SEIPIN Binds Anionic Phospholipids. Dev Cell. 2018;47(2):248–256.e4. PMID: 30293840
    Reference Link
  • 1.
    Pan X, Li Z, Zhou Q, Shen H, Wu K, Huang X, Chen J, Zhang J, Zhu X, Lei J, Xiong W, Gong H, Xiao B, Yan N. Structure of the human voltage-gated sodium channel Na1.4 in complex with β1. Science. 2018;362(6412). PMID: 30190309
    Reference Link
  • 1.
    Shen H, Li Z, Jiang Y, Pan X, Wu J, Cristofori-Armstrong B, Smith J, K Y Chin Y, Lei J, Zhou Q, King G, Yan N. Structural basis for the modulation of voltage-gated sodium channels by animal toxins. Science. 2018;362(6412). PMID: 30049784
    Reference Link
  • 1.
    Gong X, Qian H, Cao P, Zhao X, Zhou Q, Lei J, Yan N. Structural basis for the recognition of Sonic Hedgehog by human Patched1. Science. 2018;361(6402). PMID: 29954986
    Reference Link
  • 1.
    Yan Z, Zhou Q, Wang L, Wu J, Zhao Y, Huang G, Peng W, Shen H, Lei J, Yan N. Structure of the Na1.4-β1 Complex from Electric Eel. Cell. 2017;170(3):470–482.e11. PMID: 28735751
    Reference Link
  • 1.
    Yan Z, Bai X, Yan C, Wu J, Li Z, Xie T, Peng W, Yin C, Li X, Scheres S, Shi Y, Yan N. Structure of the rabbit ryanodine receptor RyR1 at near-atomic resolution. Nature. 2015;517(7532):50–55. PMCID: PMC4338550
    Reference Link
  • 1.
    Fernández-Capetillo Óscar, Yan N, Dionne J, Bassett D, Sebastian S, Hendon C, Schlichting H, Baker M. Hopes for the year ahead. Nature. 2015;517(7532):111–3. PMID: 25568916
    Reference Link
  • 1.
    Wu J, Yan Z, Li Z, Yan C, Lu S, Dong M, Yan N. Structure of the voltage-gated calcium channel Cav1.1 complex. Science. 2015;350(6267):aad2395. PMID: 26680202
    Reference Link
  • 1.
    Bai X-C, Yan Z, Wu J, Li Z, Yan N. The Central domain of RyR1 is the transducer for long-range allosteric gating of channel opening. Cell Res. 2016;26(9):995–1006. PMCID: PMC5034110
    Reference Link
  • 1.
    Peng W, Shen H, Wu J, Guo W, Pan X, Wang R, Chen S, Yan N. Structural basis for the gating mechanism of the type 2 ryanodine receptor RyR2. Science. 2016;354(6310). PMID: 27708056
    Reference Link
  • 1.
    Gong X, Qian H, Shao W, Li J, Wu J, Liu J-J, Li W, Wang H-W, Espenshade P, Yan N. Complex structure of the fission yeast SREBP-SCAP binding domains reveals an oligomeric organization. Cell Res. 2016;26(11):1197–1211. PMCID: PMC5099872
    Reference Link
  • 1.
    Shen H, Zhou Q, Pan X, Li Z, Wu J, Yan N. Structure of a eukaryotic voltage-gated sodium channel at near-atomic resolution. Science. 2017;355(6328). PMID: 28183995
    Reference Link
  • 1.
    Qian H, Zhao X, Cao P, Lei J, Yan N, Gong X. Structure of the Human Lipid Exporter ABCA1. Cell. 2017;169(7):1228–1239.e10. PMID: 28602350
    Reference Link
  • 1.
    Hogue I, Jean J, Esteves A, Tanneti N, Scherer J, Enquist L. Functional Carboxy-Terminal Fluorescent Protein Fusion to Pseudorabies Virus Small Capsid Protein VP26. J Virol. 2018;92(1). PMCID: PMC5730785
    Reference Link
  • 1.
    Rosenzweig E, Xu B, Cuellar L, Martinez-Sanchez A, Schaffer M, Strauss M, Cartwright H, Ronceray P, Plitzko J, Förster F, Wingreen N, Engel B, Mackinder L, Jonikas M. The Eukaryotic CO-Concentrating Organelle Is Liquid-like and Exhibits Dynamic Reorganization. Cell. 2017;171(1):148–162.e19. PMCID: PMC5671343
    Reference Link
  • 1.
    Lynch E, Hicks D, Shepherd M, Endrizzi J, Maker A, Hansen J, Barry R, Gitai Z, Baldwin E, Kollman J. Human CTP synthase filament structure reveals the active enzyme conformation. Nat Struct Mol Biol. 2017;24(6):507–514. PMCID: PMC5472220
    Reference Link
  • 1.
    Hagen C, Dent K, Zeev-Ben-Mordehai T, Grange M, Bosse J, Whittle C, Klupp B, Siebert A, Vasishtan D, Bäuerlein F, Cheleski J, Werner S, Guttmann P, Rehbein S, Henzler K, Demmerle J, Adler B, Koszinowski U, Schermelleh L, Schneider G, Enquist L, Plitzko J, Mettenleiter T, Grünewald K. Structural Basis of Vesicle Formation at the Inner Nuclear Membrane. Cell. 2015;163(7):1692–701. PMCID: PMC4701712
    Reference Link

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