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Computational Biology

  • 1.
    Han E, Lee S, Hoshino S, Seyedsayamdost M. Targeted Discovery of Cryptic Metabolites with Antiproliferative Activity. ACS Chem Biol. 2022;17(11):3121–3130. PMID: 36228140
    Reference Link
  • 1.
    Clark K, Seyedsayamdost M. Bioinformatic Atlas of Radical SAM Enzyme-Modified RiPP Natural Products Reveals an Isoleucine-Tryptophan Crosslink. J Am Chem Soc. 2022;144(39):17876–17888. PMID: 36128669
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  • 1.
    Weiner B, Pyo A, Meir Y, Wingreen N. Motif-pattern dependence of biomolecular phase separation driven by specific interactions. PLoS Comput Biol. 2021;17(12):e1009748. PMCID: PMC8751999
    Reference Link
  • 1.
    Covington B, Seyedsayamdost M. MetEx, a Metabolomics Explorer Application for Natural Product Discovery. ACS Chem Biol. 2021;16(12):2825–2833. PMCID: PMC9090437
    Reference Link
  • 1.
    King S, Singh M. Comparative genomic analysis reveals varying levels of mammalian adaptation to coronavirus infections. PLoS Comput Biol. 2021;17(11):e1009560. PMCID: PMC8601562
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  • 1.
    Zhou J, Troyanskaya O. An analytical framework for interpretable and generalizable single-cell data analysis. Nat Methods. 2021;18(11):1317–1321. PMCID: PMC8959118
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  • 1.
    Kloosterman A, Cimermancic P, Elsayed S, Du C, Hadjithomas M, Donia M, Fischbach M, van Wezel G, Medema M. Expansion of RiPP biosynthetic space through integration of pan-genomics and machine learning uncovers a novel class of lanthipeptides. PLoS Biol. 2020;18(12):e3001026. PMCID: PMC7794033
    Reference Link
  • 1.
    Montalbán-López M, Scott T, Ramesh S, Rahman I, van Heel A, Viel J, Bandarian V, Dittmann E, Genilloud O, Goto Y, Burgos M, Hill C, Kim S, Koehnke J, Latham J, Link J, Martínez B, Nair S, Nicolet Y, Rebuffat S, Sahl H-G, Sareen D, Schmidt E, Schmitt L, Severinov K, Süssmuth R, Truman A, Wang H, Weng J-K, van Wezel G, Zhang Q, Zhong J, Piel J, Mitchell D, Kuipers O, van der Donk W. New developments in RiPP discovery, enzymology and engineering. Nat Prod Rep. 2021;38(1):130–239. PMCID: PMC7864896
    Reference Link
  • 1.
    Stern T, Shvartsman S, Wieschaus E. Template-based mapping of dynamic motifs in tissue morphogenesis. PLoS Comput Biol. 2020;16(8):e1008049. PMCID: PMC7442231
    Reference Link
  • 1.
    Federspiel J, Cook K, Kennedy M, Venkatesh S, Otter C, Hofstadter W, Beltran P, Cristea I. Mitochondria and Peroxisome Remodeling across Cytomegalovirus Infection Time Viewed through the Lens of Inter-ViSTA. Cell Rep. 2020;32(4):107943. PMCID: PMC8489195
    Reference Link
  • 1.
    Sealfon R, Mariani L, Kretzler M, Troyanskaya O. Machine learning, the kidney, and genotype-phenotype analysis. Kidney Int. 2020;97(6):1141–1149. PMCID: PMC8048707
    Reference Link
  • 1.
    Cabreros I, Storey J. A Likelihood-Free Estimator of Population Structure Bridging Admixture Models and Principal Components Analysis. Genetics. 2019;212(4):1009–1029. PMCID: PMC6707457
    Reference Link
  • 1.
    Wang R, Zheng J, Shao X, Ishii Y, Roy A, Bello A, Lee R, Zhang J, Wind-Rotolo M, Feng Y. Development of a prognostic composite cytokine signature based on the correlation with nivolumab clearance: translational PK/PD analysis in patients with renal cell carcinoma. J Immunother Cancer. 2019;7(1):348. PMCID: PMC6907258
    Reference Link
  • 1.
    Arguello E, Leach R, Kleiner R. Selection with a Site-Specifically Modified RNA Library Reveals the Binding Preferences of N-Methyladenosine Reader Proteins. Biochemistry. 2019;58(31):3386–3395. PMCID: PMC6684389
    Reference Link
  • 1.
    Bushin L, Clark K, Pelczer I, Seyedsayamdost M. Charting an Unexplored Streptococcal Biosynthetic Landscape Reveals a Unique Peptide Cyclization Motif. J Am Chem Soc. 2018;140(50):17674–17684. PMID: 30398325
    Reference Link
  • 1.
    Zhou J, Schor I, Yao V, Theesfeld C, Marco-Ferreres R, Tadych A, Furlong E, Troyanskaya O. Accurate genome-wide predictions of spatio-temporal gene expression during embryonic development. PLoS Genet. 2019;15(9):e1008382. PMCID: PMC6779412
    Reference Link
  • 1.
    Durán A, Greco T, Vollmer B, Cristea I, Grünewald K, Topf M. Protein interactions and consensus clustering analysis uncover insights into herpesvirus virion structure and function relationships. PLoS Biol. 2019;17(6):e3000316. PMCID: PMC6594648
    Reference Link
  • 1.
    Clark K, Bushin L, Seyedsayamdost M. Aliphatic Ether Bond Formation Expands the Scope of Radical SAM Enzymes in Natural Product Biosynthesis. J Am Chem Soc. 2019;141(27):10610–10615. PMID: 31246011
    Reference Link
  • 1.
    Giovannucci A, Friedrich J, Gunn P, Kalfon J, Brown B, Koay S, Taxidis J, Najafi F, Gauthier J, Zhou P, Khakh B, Tank D, Chklovskii D, Pnevmatikakis E. CaImAn an open source tool for scalable calcium imaging data analysis. Elife. 2019;8. PMCID: PMC6342523
    Reference Link
  • 1.
    Zhou J, Park C, Theesfeld C, Wong A, Yuan Y, Scheckel C, Fak J, Funk J, Yao K, Tajima Y, Packer A, Darnell R, Troyanskaya O. Whole-genome deep-learning analysis identifies contribution of noncoding mutations to autism risk. Nat Genet. 2019;51(6):973–980. PMCID: PMC6758908
    Reference Link
  • 1.
    Wang S-W, Bitbol A-F, Wingreen N. Revealing evolutionary constraints on proteins through sequence analysis. PLoS Comput Biol. 2019;15(4):e1007010. PMCID: PMC6502352
    Reference Link
  • 1.
    Seyedsayamdost M. Toward a global picture of bacterial secondary metabolism. J Ind Microbiol Biotechnol. 2019;46(3-4):301–311. PMCID: PMC6779422
    Reference Link
  • 1.
    Chen K, Cofer E, Zhou J, Troyanskaya O. Selene: a PyTorch-based deep learning library for sequence data. Nat Methods. 2019;16(4):315–318. PMCID: PMC7148117
    Reference Link
  • 1.
    Moon K, Xu F, Zhang C, Seyedsayamdost M. Bioactivity-HiTES Unveils Cryptic Antibiotics Encoded in Actinomycete Bacteria. ACS Chem Biol. 2019;14(4):767–774. PMCID: PMC6813803
    Reference Link
  • 1.
    Liszczak G, Muir T. Nucleic Acid-Barcoding Technologies: Converting DNA Sequencing into a Broad-Spectrum Molecular Counter. Angew Chem Int Ed Engl. 2019;58(13):4144–4162. PMCID: PMC6748390
    Reference Link
  • 1.
    DiMaio D, Dermody T, Enquist L. Reductio ad Intellectum. Annu Rev Virol. 2018;5(1):ii-iv. PMID: 30265630
    Reference Link
  • 1.
    Sigoillot F, Lyman S, Huckins J, Adamson B, Chung E, Quattrochi B, King R. A bioinformatics method identifies prominent off-targeted transcripts in RNAi screens. Nat Methods. 2012;9(4):363–6. PMCID: PMC3482495
    Reference Link
  • 1.
    Wong A, Krishnan A, Troyanskaya O. GIANT 2.0: genome-scale integrated analysis of gene networks in tissues. Nucleic Acids Res. 2018;46(W1):W65-W70. PMCID: PMC6030827
    Reference Link
  • 1.
    Davis K, Schramma K, Hansen W, Bacik J, Khare S, Seyedsayamdost M, Ando N. Structures of the peptide-modifying radical SAM enzyme SuiB elucidate the basis of substrate recognition. Proc Natl Acad Sci U S A. 2017;114(39):10420–10425. PMCID: PMC5625900
    Reference Link
  • 1.
    Donnelly A, Murphy G, Digianantonio K, Hecht M. A de novo enzyme catalyzes a life-sustaining reaction in Escherichia coli. Nat Chem Biol. 2018;14(3):253–255. PMID: 29334382
    Reference Link
  • 1.
    Ioffe M, Berry M. The structured ’low temperature’ phase of the retinal population code. PLoS Comput Biol. 2017;13(10):e1005792. PMCID: PMC5654267
    Reference Link
  • 1.
    Villoutreix P, Andén J, Lim B, Lu H, Kevrekidis I, Singer A, Shvartsman S. Synthesizing developmental trajectories. PLoS Comput Biol. 2017;13(9):e1005742. PMCID: PMC5619836
    Reference Link
  • 1.
    Hristov B, Singh M. Network-Based Coverage of Mutational Profiles Reveals Cancer Genes. Cell Syst. 2017;5(3):221–229.e4. PMCID: PMC5997485
    Reference Link
  • 1.
    Calhoun A, Murthy M. Quantifying behavior to solve sensorimotor transformations: advances from worms and flies. Curr Opin Neurobiol. 2017;46:90–98. PMCID: PMC5765764
    Reference Link
  • 1.
    Lu Y, Xie S, Zhang W, Zhang C, Gao C, Sun Q, Cai Y, Xu Z, Xiao M, Xu Y, Huang X, Wu X, Liu W, Wang F, Kang Y, Zhou T. Twa1/Gid8 is a β-catenin nuclear retention factor in Wnt signaling and colorectal tumorigenesis. Cell Res. 2017;27(12):1422–1440. PMCID: PMC5717399
    Reference Link
  • 1.
    vonHoldt B, Shuldiner E, Koch I, Kartzinel R, Hogan A, Brubaker L, Wanser S, Stahler D, Wynne C, Ostrander E, Sinsheimer J, Udell M. Structural variants in genes associated with human Williams-Beuren syndrome underlie stereotypical hypersociability in domestic dogs. Sci Adv. 2017;3(7):e1700398. PMCID: PMC5517105
    Reference Link
  • 1.
    Ochoa A, Singh M. Domain prediction with probabilistic directional context. Bioinformatics. 2017;33(16):2471–2478. PMCID: PMC5870623
    Reference Link
  • 1.
    Misra M, Audoly B, Shvartsman S. Complex structures from patterned cell sheets. Philos Trans R Soc Lond B Biol Sci. 2017;372(1720). PMCID: PMC5379023
    Reference Link
  • 1.
    Beltran P, Federspiel J, Sheng X, Cristea I. Proteomics and integrative omic approaches for understanding host-pathogen interactions and infectious diseases. Mol Syst Biol. 2017;13(3):922. PMCID: PMC5371729
    Reference Link
  • 1.
    Ashford P, Hernandez A, Greco T, Buch A, Sodeik B, Cristea I, Grünewald K, Shepherd A, Topf M. HVint: A Strategy for Identifying Novel Protein-Protein Interactions in Herpes Simplex Virus Type 1. Mol Cell Proteomics. 2016;15(9):2939–53. PMCID: PMC5013309
    Reference Link
  • 1.
    Gopalan P, Hao W, Blei D, Storey J. Scaling probabilistic models of genetic variation to millions of humans. Nat Genet. 2016;48(12):1587–1590. PMCID: PMC5127768
    Reference Link
  • 1.
    Adolfsen K, Brynildsen M. A Kinetic Platform to Determine the Fate of Hydrogen Peroxide in Escherichia coli. PLoS Comput Biol. 2015;11(11):e1004562. PMCID: PMC4636272
    Reference Link
  • 1.
    Gorenshteyn D, Zaslavsky E, Fribourg M, Park C, Wong A, Tadych A, Hartmann B, Albrecht R, García-Sastre A, Kleinstein S, Troyanskaya O, Sealfon S. Interactive Big Data Resource to Elucidate Human Immune Pathways and Diseases. Immunity. 2015;43(3):605–14. PMCID: PMC4753773
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  • 1.
    Ochoa A, Storey J, Llinás M, Singh M. Beyond the E-Value: Stratified Statistics for Protein Domain Prediction. PLoS Comput Biol. 2015;11(11):e1004509. PMCID: PMC4648515
    Reference Link
  • 1.
    Seyedsayamdost M, Cleto S, Carr G, Vlamakis H, Vieira M, Kolter R, Clardy J. Mixing and matching siderophore clusters: structure and biosynthesis of serratiochelins from Serratia sp. V4. J Am Chem Soc. 2012;134(33):13550–3. PMCID: PMC3424848
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  • 1.
    Medema M, Kottmann R, Yilmaz P, Cummings M, Biggins J, Blin K, de Bruijn I, Chooi Y, Claesen J, Coates C, Cruz-Morales P, Duddela S, Düsterhus S, Edwards D, Fewer D, Garg N, Geiger C, Gomez-Escribano J, Greule A, Hadjithomas M, Haines A, Helfrich E, Hillwig M, Ishida K, Jones A, Jones C, Jungmann K, Kegler C, Kim H, Kötter P, Krug D, Masschelein J, Melnik A, Mantovani S, Monroe E, Moore M, Moss N, Nützmann H-W, Pan G, Pati A, Petras D, Reen J, Rosconi F, Rui Z, Tian Z, Tobias N, Tsunematsu Y, Wiemann P, Wyckoff E, Yan X, Yim G, Yu F, Xie Y, Aigle B, Apel A, Balibar C, Balskus E, Barona-Gómez F, Bechthold A, Bode H, Borriss R, Brady S, Brakhage A, Caffrey P, Cheng Y-Q, Clardy J, Cox R, De Mot R, Donadio S, Donia M, van der Donk W, Dorrestein P, Doyle S, Driessen A, Ehling-Schulz M, Entian K-D, Fischbach M, Gerwick L, Gerwick W, Gross H, Gust B, Hertweck C, Höfte M, Jensen S, Ju J, Katz L, Kaysser L, Klassen J, Keller N, Kormanec J, Kuipers O, Kuzuyama T, Kyrpides N, Kwon H-J, Lautru S, Lavigne R, Lee C, Linquan B, Liu X, Liu W, Luzhetskyy A, Mahmud T, Mast Y, Méndez C, Metsä-Ketelä M, Micklefield J, Mitchell D, Moore B, Moreira L, Müller R, Neilan B, Nett M, Nielsen J, O’Gara F, Oikawa H, Osbourn A, Osburne M, Ostash B, Payne S, Pernodet J-L, Petricek M, Piel J, Ploux O, Raaijmakers J, Salas J, Schmitt E, Scott B, Seipke R, Shen B, Sherman D, Sivonen K, Smanski M, Sosio M, Stegmann E, Süssmuth R, Tahlan K, Thomas C, Tang Y, Truman A, Viaud M, Walton J, Walsh C, Weber T, van Wezel G, Wilkinson B, Willey J, Wohlleben W, Wright G, Ziemert N, Zhang C, Zotchev S, Breitling R, Takano E, Glöckner F. Minimum Information about a Biosynthetic Gene cluster. Nat Chem Biol. 2015;11(9):625–31. PMCID: PMC5714517
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    Toettcher J, Gong D, Lim W, Weiner O. Light-based feedback for controlling intracellular signaling dynamics. Nat Methods. 2011;8(10):837–9. PMCID: PMC3184382
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    Wühr M, Freeman R, Presler M, Horb M, Peshkin L, Gygi S, Kirschner M. Deep proteomics of the Xenopus laevis egg using an mRNA-derived reference database. Curr Biol. 2014;24(13):1467–1475. PMCID: PMC4090281
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    Tkačik G, Marre O, Amodei D, Schneidman E, Bialek W, Berry M. Searching for collective behavior in a large network of sensory neurons. PLoS Comput Biol. 2014;10(1):e1003408. PMCID: PMC3879139
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    da Silveira R, Berry M. High-fidelity coding with correlated neurons. PLoS Comput Biol. 2014;10(11):e1003970. PMCID: PMC4238954
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