Son J, Du W, Esposito M, Shariati K, Ding H, Kang Y, Accili D. Genetic and pharmacologic inhibition of ALDH1A3 as a treatment of β-cell failure. Nat Commun. 2023;14(1):558. PMCID: PMC9895451

Chen H, Zhan M, Liu J, Liu Z, Shen M, Yang F, Kang Y, Yin F, Li Z. Structure-Based Design, Optimization, and Evaluation of Potent Stabilized Peptide Inhibitors Disrupting MTDH and SND1 Interaction. J Med Chem. 2022;65(18):12188–12199. PMID: 36044768

Ghergurovich J, Xu X, Wang J, Yang L, Ryseck R-P, Wang L, Rabinowitz J. Methionine synthase supports tumour tetrahydrofolate pools. Nat Metab. 2021;3(11):1512–1520. PMCID: PMC9284419

Chitrakar A, Solorio-Kirpichyan K, Prangley E, Rath S, Du J, Korennykh A. Introns encode dsRNAs undetected by RIG-I/MDA5/interferons and sensed via RNase L. Proc Natl Acad Sci U S A. 2021;118(46). PMCID: PMC8609619

Wilke A, Doebele C, Zindel A, Lee K, Rieke S, Ceribelli M, Comoglio F, Phelan J, Wang J, Pikman Y, Jahn D, Häupl B, Schneider C, Scheich S, Tosto F, Bohnenberger H, Stauder P, Schnütgen F, Slabicki M, Coulibaly Z, Wolf S, Bojarczuk K, Chapuy B, Brandts C, Stroebel P, Lewis C, Engelke M, Xu X, Kim H, Dang T, Schmitz R, Hodson D, Stegmaier K, Urlaub H, Serve H, Schmitt C, Kreuz F, Knittel G, Rabinowitz J, Reinhardt H, Heiden M, Thomas C, Staudt L, Zenz T, Oellerich T. SHMT2 inhibition disrupts the TCF3 transcriptional survival program in Burkitt lymphoma. Blood. 2022;139(4):538–553. PMCID: PMC8938936

Shimobayashi S, Ronceray P, Sanders D, Haataja M, Brangwynne C. Nucleation landscape of biomolecular condensates. Nature. 2021;599(7885):503–506. PMID: 34552246

Kumar S, Nandi A, Singh S, Regulapati R, Li N, Tobias J, Siebel C, Blanco M, Klein-Szanto A, Lengner C, Welm A, Kang Y, Chakrabarti R. Dll1 quiescent tumor stem cells drive chemoresistance in breast cancer through NF-κB survival pathway. Nat Commun. 2021;12(1):432. PMCID: PMC7813834

Quinn J, Jones M, Okimoto R, Nanjo S, Chan M, Yosef N, Bivona T, Weissman J. Single-cell lineages reveal the rates, routes, and drivers of metastasis in cancer xenografts. Science. 2021;371(6532). PMCID: PMC7983364

Phan T, Nguyen V, Buettner R, Morales C, Yang L, Wong P, Tsai W, Salazar M, Gil Z, Diamond D, Rabinowitz J, Rosen S, Melstrom L. Inhibition of pyrimidine synthesis augments Gemcitabine induced growth inhibition in an immunocompetent model of pancreatic cancer. Int J Biol Sci. 2021;17(9):2240–2251. PMCID: PMC8241727

Zhang Y, Lee D, Meir Y, Brangwynne C, Wingreen N. Mechanical Frustration of Phase Separation in the Cell Nucleus by Chromatin. Phys Rev Lett. 2021;126(25):258102. PMCID: PMC8604804

Schild T, McReynolds M, Shea C, Low V, Schaffer B, Asara J, Piskounova E, Dephoure N, Rabinowitz J, Gomes A, Blenis J. NADK is activated by oncogenic signaling to sustain pancreatic ductal adenocarcinoma. Cell Rep. 2021;35(11):109238. PMID: 34133937

Wu A, Zhi J, Tian T, Cihan A, Cevher M, Liu Z, David Y, Muir T, Roeder R, Yu M. DOT1L complex regulates transcriptional initiation in human erythroleukemic cells. Proc Natl Acad Sci U S A. 2021;118(27). PMCID: PMC8271641

Wei L, Ploss A. Hepatitis B virus cccDNA is formed through distinct repair processes of each strand. Nat Commun. 2021;12(1):1591. PMCID: PMC7952586

Cho S, Lee G, Pickering B, Jang C, Park J, He L, Mathur L, Kim S-S, Jung S, Tang H-W, Monette S, Rabinowitz J, Perrimon N, Jaffrey S, Blenis J. mTORC1 promotes cell growth via mA-dependent mRNA degradation. Mol Cell. 2021;81(10):2064–2075.e8. PMCID: PMC8356906

Esposito M, Fang C, Cook K, Park N, Wei Y, Spadazzi C, Bracha D, Gunaratna R, Laevsky G, DeCoste C, Slabodkin H, Brangwynne C, Cristea I, Kang Y. TGF-β-induced DACT1 biomolecular condensates repress Wnt signalling to promote bone metastasis. Nat Cell Biol. 2021;23(3):257–267. PMCID: PMC7970447

Rabie E, Zhang S, Kourouklis A, Kilinc N, Simi A, Radisky D, Tien J, Nelson C. Matrix degradation and cell proliferation are coupled to promote invasion and escape from an engineered human breast microtumor. Integr Biol (Camb). 2021;13(1):17–29. PMCID: PMC7856634

Nimgaonkar I, Archer N, Becher I, Shahrad M, LeDesma R, Mateus A, Caballero-Gómez J, Berneshawi A, Ding Q, Douam F, Gaska J, Savitski M, Kim H, Ploss A. Isocotoin suppresses hepatitis E virus replication through inhibition of heat shock protein 90. Antiviral Res. 2021;185:104997. PMCID: PMC8649941

Ringel A, Drijvers J, Baker G, Catozzi A, García-Cañaveras J, Gassaway B, Miller B, Juneja V, Nguyen T, Joshi S, Yao C-H, Yoon H, Sage P, LaFleur M, Trombley J, Jacobson C, Maliga Z, Gygi S, Sorger P, Rabinowitz J, Sharpe A, Haigis M. Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity. Cell. 2020;183(7):1848–1866.e26. PMCID: PMC8064125

Nogalski M, Shenk T. HSATII RNA is induced via a noncanonical ATM-regulated DNA damage response pathway and promotes tumor cell proliferation and movement. Proc Natl Acad Sci U S A. 2020;117(50):31891–31901. PMCID: PMC7749351

Anlas A, Nelson C. Soft Microenvironments Induce Chemoresistance by Increasing Autophagy Downstream of Integrin-Linked Kinase. Cancer Res. 2020;80(19):4103–4113. PMCID: PMC7534696

Fan H, Wang X, Li W, Shen M, Wei Y, Zheng H, Kang Y. ASB13 inhibits breast cancer metastasis through promoting SNAI2 degradation and relieving its transcriptional repression of YAP. Genes Dev. 2020;34(19-20):1359–1372. PMCID: PMC7528707

McBride M, Mashtalir N, Winter E, Dao H, Filipovski M, D’Avino A, Seo H-S, Umbreit N, St Pierre R, Valencia A, Qian K, Zullow H, Jaffe J, Dhe-Paganon S, Muir T, Kadoch C. The nucleosome acidic patch and H2A ubiquitination underlie mSWI/SNF recruitment in synovial sarcoma. Nat Struct Mol Biol. 2020;27(9):836–845. PMCID: PMC7714695

Ghergurovich J, Esposito M, Chen Z, Wang J, Bhatt V, Lan T, White E, Kang Y, Guo J, Rabinowitz J. Glucose-6-Phosphate Dehydrogenase Is Not Essential for K-Ras-Driven Tumor Growth or Metastasis. Cancer Res. 2020;80(18):3820–3829. PMCID: PMC7501231

Zhang Y, Kleiner R. A Metabolic Engineering Approach to Incorporate Modified Pyrimidine Nucleosides into Cellular RNA. J Am Chem Soc. 2019;141(8):3347–3351. PMID: 30735369

Sanders D, Kedersha N, Lee D, Strom A, Drake V, Riback J, Bracha D, Eeftens J, Iwanicki A, Wang A, Wei M-T, Whitney G, Lyons S, Anderson P, Jacobs W, Ivanov P, Brangwynne C. Competing Protein-RNA Interaction Networks Control Multiphase Intracellular Organization. Cell. 2020;181(2):306–324.e28. PMCID: PMC7816278

Hermans D, Gautam S, García-Cañaveras J, Gromer D, Mitra S, Spolski R, Li P, Christensen S, Nguyen R, Lin J-X, Oh J, Du N, Veenbergen S, Fioravanti J, Ebina-Shibuya R, Bleck C, Neckers L, Rabinowitz J, Gattinoni L, Leonard W. Lactate dehydrogenase inhibition synergizes with IL-21 to promote CD8 T cell stemness and antitumor immunity. Proc Natl Acad Sci U S A. 2020;117(11):6047–6055. PMCID: PMC7084161

Wang R, Zheng J, Shao X, Ishii Y, Roy A, Bello A, Lee R, Zhang J, Wind-Rotolo M, Feng Y. Development of a prognostic composite cytokine signature based on the correlation with nivolumab clearance: translational PK/PD analysis in patients with renal cell carcinoma. J Immunother Cancer. 2019;7(1):348. PMCID: PMC6907258

Shen M, Kang Y. Role Reversal: A Pro-metastatic Function of E-Cadherin. Dev Cell. 2019;51(4):417–419. PMID: 31743661

Dekhne A, Shah K, Ducker G, Katinas J, Wong-Roushar J, Nayeen M, Doshi A, Ning C, Bao X, Frühauf J, Liu J, Wallace-Povirk A, O’Connor C, Dzinic S, White K, Kushner J, Kim S, Hüttemann M, Polin L, Rabinowitz J, Li J, Hou Z, Dann C, Gangjee A, Matherly L. Novel Pyrrolo[3,2-]pyrimidine Compounds Target Mitochondrial and Cytosolic One-carbon Metabolism with Broad-spectrum Antitumor Efficacy. Mol Cancer Ther. 2019;18(10):1787–1799. PMCID: PMC6774887

Jain S, Do T, Lund P, Rashoff A, Diehl K, Cieslik M, Bajic A, Juretic N, Deshmukh S, Venneti S, Muir T, Garcia B, Jabado N, Lewis P. PFA ependymoma-associated protein EZHIP inhibits PRC2 activity through a H3 K27M-like mechanism. Nat Commun. 2019;10(1):2146. PMCID: PMC6513997

Brown A, Chua N, Yan N. The shape of human squalene epoxidase expands the arsenal against cancer. Nat Commun. 2019;10(1):888. PMCID: PMC6384927

Celià-Terrassa T, Bastian C, Liu D, Ell B, Aiello N, Wei Y, Zamalloa J, Blanco A, Hang X, Kunisky D, Li W, Williams E, Rabitz H, Kang Y. Hysteresis control of epithelial-mesenchymal transition dynamics conveys a distinct program with enhanced metastatic ability. Nat Commun. 2018;9(1):5005. PMCID: PMC6258667

Esposito M, Mondal N, Greco T, Wei Y, Spadazzi C, Lin S-C, Zheng H, Cheung C, Magnani J, Lin S-H, Cristea I, Sackstein R, Kang Y. Bone vascular niche E-selectin induces mesenchymal-epithelial transition and Wnt activation in cancer cells to promote bone metastasis. Nat Cell Biol. 2019;21(5):627–639. PMCID: PMC6556210

Zhang H, Brown R, Wei Y, Zhao P, Liu S, Liu X, Deng Y, Hu X, Zhang J, Gao X, Kang Y, Mercurio A, Goel H, Cheng C. CD44 splice isoform switching determines breast cancer stem cell state. Genes Dev. 2019;33(3-4):166–179. PMCID: PMC6362815

Zhuo W, Liu Y, Li S, Guo D, Sun Q, Jin J, Rao X, Li M, Sun M, Jiang M, Xu Y, Teng L, Jin Y, Si J, Liu W, Kang Y, Zhou T. Long Noncoding RNA GMAN, Up-regulated in Gastric Cancer Tissues, Is Associated With Metastasis in Patients and Promotes Translation of Ephrin A1 by Competitively Binding GMAN-AS. Gastroenterology. 2019;156(3):676–691.e11. PMID: 30445010

Shin Y, Chang Y-C, Lee D, Berry J, Sanders D, Ronceray P, Wingreen N, Haataja M, Brangwynne C. Liquid Nuclear Condensates Mechanically Sense and Restructure the Genome. Cell. 2018;175(6):1481–1491.e13. PMCID: PMC6724728

Shen M, Jiang Y-Z, Wei Y, Ell B, Sheng X, Esposito M, Kang J, Hang X, Zheng H, Rowicki M, Zhang L, Shih W, Celià-Terrassa T, Liu Y, Cristea I, Shao Z-M, Kang Y. Tinagl1 Suppresses Triple-Negative Breast Cancer Progression and Metastasis by Simultaneously Inhibiting Integrin/FAK and EGFR Signaling. Cancer Cell. 2019;35(1):64–80.e7. PMID: 30612941

Adamson B, Smogorzewska A, Sigoillot F, King R, Elledge S. A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response. Nat Cell Biol. 2012;14(3):318–28. PMCID: PMC3290715

Ciccia A, Nimonkar A, Hu Y, Hajdu I, Achar Y, Izhar L, Petit S, Adamson B, Yoon J, Kowalczykowski S, Livingston D, Haracska L, Elledge S. Polyubiquitinated PCNA recruits the ZRANB3 translocase to maintain genomic integrity after replication stress. Mol Cell. 2012;47(3):396–409. PMCID: PMC3613862

Simi A, Anlas A, Stallings-Mann M, Zhang S, Hsia T, Cichon M, Radisky D, Nelson C. A Soft Microenvironment Protects from Failure of Midbody Abscission and Multinucleation Downstream of the EMT-Promoting Transcription Factor Snail. Cancer Res. 2018;78(9):2277–2289. PMCID: PMC5932229

Pavlova N, Hui S, Ghergurovich J, Fan J, Intlekofer A, White R, Rabinowitz J, Thompson C, Zhang J. As Extracellular Glutamine Levels Decline, Asparagine Becomes an Essential Amino Acid. Cell Metab. 2018;27(2):428–438.e5. PMCID: PMC5803449

Jin L, Chun J, Pan C, Kumar A, Zhang G, Ha Y, Li D, Alesi G, Kang Y, Zhou L, Yu W-M, Magliocca K, Khuri F, Qu C-K, Metallo C, Owonikoko T, Kang S. The PLAG1-GDH1 Axis Promotes Anoikis Resistance and Tumor Metastasis through CamKK2-AMPK Signaling in LKB1-Deficient Lung Cancer. Mol Cell. 2018;69(1):87–99.e7. PMCID: PMC5777230

Ducker G, Ghergurovich J, Mainolfi N, Suri V, Jeong S, Li S, Friedman A, Manfredi M, Gitai Z, Kim H, Rabinowitz J. Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma. Proc Natl Acad Sci U S A. 2017;114(43):11404–11409. PMCID: PMC5664509

Liu D, Kang Y. Ets2 anchors the prometastatic function of mutant p53 in osteosarcoma. Genes Dev. 2017;31(18):1823–1824. PMCID: PMC5695082

Oberstein A, Shenk T. Cellular responses to human cytomegalovirus infection: Induction of a mesenchymal-to-epithelial transition (MET) phenotype. Proc Natl Acad Sci U S A. 2017;114(39):E8244-E8253. PMCID: PMC5625929

Alečković M, Wei Y, LeRoy G, Sidoli S, Liu D, Garcia B, Kang Y. Identification of Nidogen 1 as a lung metastasis protein through secretome analysis. Genes Dev. 2017;31(14):1439–1455. PMCID: PMC5588926

Piotrowski-Daspit A, Nerger B, Wolf A, Sundaresan S, Nelson C. Dynamics of Tissue-Induced Alignment of Fibrous Extracellular Matrix. Biophys J. 2017;113(3):702–713. PMCID: PMC5550306

Goglia A, Wilson M, DiGiorno D, Toettcher J. Optogenetic Control of Ras/Erk Signaling Using the Phy-PIF System. Methods Mol Biol. 2017;1636:3–20. PMID: 28730469

Rajeshkumar N, Yabuuchi S, Pai S, De Oliveira E, Kamphorst J, Rabinowitz J, Tejero H, Al-Shahrour F, Hidalgo M, Maitra A, Dang C. Treatment of Pancreatic Cancer Patient-Derived Xenograft Panel with Metabolic Inhibitors Reveals Efficacy of Phenformin. Clin Cancer Res. 2017;23(18):5639–5647. PMCID: PMC6540110

Peng J, Kang Y. The Bony Side of Endothelial Cells in Prostate Cancer. Dev Cell. 2017;41(5):451–452. PMID: 28586639