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Caenorhabditis elegans

  • 1.
    Cota V, Sohrabi S, Kaletsky R, Murphy C. Oocyte mitophagy is critical for extended reproductive longevity. PLoS Genet. 2022;18(9):e1010400. PMCID: PMC9524673
    Reference Link
  • 1.
    McIntyre L, Huertas F, Morse A, Kaletsky R, Murphy C, Kalia V, Miller G, Moskalenko O, Conesa A, Mor D. GAIT-GM integrative cross-omics analyses reveal cholinergic defects in a C. elegans model of Parkinson’s disease. Sci Rep. 2022;12(1):3268. PMCID: PMC8885929
    Reference Link
  • 1.
    McEnany J, Meir Y, Wingreen N. piRNAs of Caenorhabditis elegans broadly silence nonself sequences through functionally random targeting. Nucleic Acids Res. 2022;50(3):1416–1429. PMCID: PMC8860604
    Reference Link
  • 1.
    Rahimi M, Sohrabi S, Murphy C. Novel elasticity measurements reveal C. elegans cuticle stiffens with age and in a long-lived mutant. Biophys J. 2022;121(4):515–524. PMCID: PMC8874029
    Reference Link
  • 1.
    Sohrabi S, Moore R, Murphy C. CeAid: a smartphone application for logging and plotting Caenorhabditis elegans assays. G3 (Bethesda). 2021;11(10). PMCID: PMC8473968
    Reference Link
  • 1.
    Hallinen K, Dempsey R, Scholz M, Yu X, Linder A, Randi F, Sharma A, Shaevitz J, Leifer A. Decoding locomotion from population neural activity in moving . Elife. 2021;10. PMCID: PMC8439659
    Reference Link
  • 1.
    Shi C, Murphy C. Sex and death. Curr Top Dev Biol. 2021;144:353–375. PMID: 33992158
    Reference Link
  • 1.
    Sohrabi S, Mor D, Kaletsky R, Keyes W, Murphy C. High-throughput behavioral screen in C. elegans reveals Parkinson’s disease drug candidates. Commun Biol. 2021;4(1):203. PMCID: PMC7884385
    Reference Link
  • 1.
    Baumeister R, Murphy C, Heimbucher T. Metabolic adaptation to hypoxia: do worms and cancer cells share common metabolic responses to hypoxic stress?. Cell Death Differ. 2021;28(4):1434–1436. PMCID: PMC8026991
    Reference Link
  • 1.
    Moore R, Kaletsky R, Lesnik C, Cota V, Blackman E, Parsons L, Gitai Z, Murphy C. The role of the Cer1 transposon in horizontal transfer of transgenerational memory. Cell. 2021;184(18):4697–4712.e18. PMCID: PMC8812995
    Reference Link
  • 1.
    Cofer E, Raimundo J, Tadych A, Yamazaki Y, Wong A, Theesfeld C, Levine M, Troyanskaya O. Modeling transcriptional regulation of model species with deep learning. Genome Res. 2021;31(6):1097–1105. PMCID: PMC8168591
    Reference Link
  • 1.
    Moore R, Kaletsky R, Murphy C. Protocol for transgenerational learned pathogen avoidance behavior assays in . STAR Protoc. 2021;2(1):100384. PMCID: PMC7960678
    Reference Link
  • 1.
    Lee Y, Jung Y, Jeong D-E, Hwang W, Ham S, Park H-E, Kwon S, Ashraf J, Murphy C, Lee S-J. Reduced insulin/IGF1 signaling prevents immune aging via ZIP-10/bZIP-mediated feedforward loop. J Cell Biol. 2021;220(5). PMCID: PMC7941181
    Reference Link
  • 1.
    Chen Y-C, Seyedsayamdost M, Ringstad N. A microbial metabolite synergizes with endogenous serotonin to trigger reproductive behavior. Proc Natl Acad Sci U S A. 2020;117(48):30589–30598. PMCID: PMC7720207
    Reference Link
  • 1.
    Heimbucher T, Hog J, Gupta P, Murphy C. PQM-1 controls hypoxic survival via regulation of lipid metabolism. Nat Commun. 2020;11(1):4627. PMCID: PMC7532158
    Reference Link
  • 1.
    Mor D, Sohrabi S, Kaletsky R, Keyes W, Tartici A, Kalia V, Miller G, Murphy C. Metformin rescues Parkinson’s disease phenotypes caused by hyperactive mitochondria. Proc Natl Acad Sci U S A. 2020;117(42):26438–26447. PMCID: PMC7585014
    Reference Link
  • 1.
    Kaletsky R, Moore R, Vrla G, Parsons L, Gitai Z, Murphy C. C. elegans interprets bacterial non-coding RNAs to learn pathogenic avoidance. Nature. 2020;586(7829):445–451. PMCID: PMC8547118
    Reference Link
  • 1.
    Templeman N, Cota V, Keyes W, Kaletsky R, Murphy C. CREB Non-autonomously Controls Reproductive Aging through Hedgehog/Patched Signaling. Dev Cell. 2020;54(1):92–105.e5. PMCID: PMC7837322
    Reference Link
  • 1.
    Kaletsky R, Murphy C. Transcriptional Profiling of C. elegans Adult Cells and Tissues with Age. Methods Mol Biol. 2020;2144:177–186. PMID: 32410035
    Reference Link
  • 1.
    Murphy C. Short and sweet. Elife. 2020;9. PMCID: PMC7041940
    Reference Link
  • 1.
    Arey R, Kaletsky R, Murphy C. Nervous system-wide profiling of presynaptic mRNAs reveals regulators of associative memory. Sci Rep. 2019;9(1):20314. PMCID: PMC6937282
    Reference Link
  • 1.
    Shi C, Booth L, Murphy C. Insulin-like peptides and the mTOR-TFEB pathway protect hermaphrodites from mating-induced death. Elife. 2019;8. PMCID: PMC6697448
    Reference Link
  • 1.
    Moore R, Kaletsky R, Murphy C. Piwi/PRG-1 Argonaute and TGF-β Mediate Transgenerational Learned Pathogenic Avoidance. Cell. 2019;177(7):1827–1841.e12. PMCID: PMC7518193
    Reference Link
  • 1.
    McCready A, Paczkowski J, Cong J-P, Bassler B. An autoinducer-independent RhlR quorum-sensing receptor enables analysis of RhlR regulation. PLoS Pathog. 2019;15(6):e1007820. PMCID: PMC6564026
    Reference Link
  • 1.
    Heimbucher T, Murphy C. A PBX/MEIS Complex Balances Reproduction and Somatic Resilience. Dev Cell. 2019;49(2):157–158. PMCID: PMC7452753
    Reference Link
  • 1.
    Liu M, Sharma A, Shaevitz J, Leifer A. Temporal processing and context dependency in response to mechanosensation. Elife. 2018;7. PMCID: PMC6054533
    Reference Link
  • 1.
    Tabuchi T, Rechtsteiner A, Jeffers T, Egelhofer T, Murphy C, Strome S. Caenorhabditis elegans sperm carry a histone-based epigenetic memory of both spermatogenesis and oogenesis. Nat Commun. 2018;9(1):4310. PMCID: PMC6193031
    Reference Link
  • 1.
    Chou D, Adamson B, Dephoure N, Tan X, Nottke A, Hurov K, Gygi S, Colaiácovo M, Elledge S. A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage. Proc Natl Acad Sci U S A. 2010;107(43):18475–80. PMCID: PMC2972950
    Reference Link
  • 1.
    Kaletsky R, Yao V, Williams A, Runnels A, Tadych A, Zhou S, Troyanskaya O, Murphy C. Transcriptome analysis of adult Caenorhabditis elegans cells reveals tissue-specific gene and isoform expression. PLoS Genet. 2018;14(8):e1007559. PMCID: PMC6105014
    Reference Link
  • 1.
    Klaus J, Deay J, Neuenswander B, Hursh W, Gao Z, Bouddhara T, Williams T, Douglas J, Monize K, Martins P, Majerczyk C, Seyedsayamdost M, Peterson B, Rivera M, Chandler J. Malleilactone Is a Burkholderia pseudomallei Virulence Factor Regulated by Antibiotics and Quorum Sensing. J Bacteriol. 2018;200(14). PMCID: PMC6018353
    Reference Link
  • 1.
    Arey R, Stein G, Kaletsky R, Kauffman A, Murphy C. Activation of G Signaling Enhances Memory Consolidation and Slows Cognitive Decline. Neuron. 2018;98(3):562–574.e5. PMCID: PMC5934306
    Reference Link
  • 1.
    Mao D, Bushin L, Moon K, Wu Y, Seyedsayamdost M. Discovery of as a global regulator of secondary metabolism and virulence in E264. Proc Natl Acad Sci U S A. 2017;114(14):E2920-E2928. PMCID: PMC5389298
    Reference Link
  • 1.
    Templeman N, Luo S, Kaletsky R, Shi C, Ashraf J, Keyes W, Murphy C. Insulin Signaling Regulates Oocyte Quality Maintenance with Age via Cathepsin B Activity. Curr Biol. 2018;28(5):753–760.e4. PMCID: PMC5893159
    Reference Link
  • 1.
    Watson E, Olin-Sandoval V, Hoy M, Li C-H, Louisse T, Yao V, Mori A, Holdorf A, Troyanskaya O, Ralser M, Walhout A. Metabolic network rewiring of propionate flux compensates vitamin B12 deficiency in C. elegans. Elife. 2016;5. PMCID: PMC4951191
    Reference Link
  • 1.
    Qi S, Pang Y, Hu Q, Liu Q, Li H, Zhou Y, He T, Liang Q, Liu Y, Yuan X, Luo G, Li H, Wang J, Yan N, Shi Y. Crystal structure of the Caenorhabditis elegans apoptosome reveals an octameric assembly of CED-4. Cell. 2010;141(3):446–57. PMID: 20434985
    Reference Link
  • 1.
    Shin Y, Brangwynne C. Liquid phase condensation in cell physiology and disease. Science. 2017;357(6357). PMID: 28935776
    Reference Link
  • 1.
    Calhoun A, Murthy M. Quantifying behavior to solve sensorimotor transformations: advances from worms and flies. Curr Opin Neurobiol. 2017;46:90–98. PMCID: PMC5765764
    Reference Link
  • 1.
    Nguyen J, Linder A, Plummer G, Shaevitz J, Leifer A. Automatically tracking neurons in a moving and deforming brain. PLoS Comput Biol. 2017;13(5):e1005517. PMCID: PMC5436637
    Reference Link
  • 1.
    Son H, Seo M, Ham S, Hwang W, Lee D, An S, Artan M, Seo K, Kaletsky R, Arey R, Ryu Y, Ha C, Kim Y, Murphy C, Roh T-Y, Nam H, Lee S-J. RNA surveillance via nonsense-mediated mRNA decay is crucial for longevity in daf-2/insulin/IGF-1 mutant C. elegans. Nat Commun. 2017;8:14749. PMCID: PMC5347137
    Reference Link
  • 1.
    Thutupalli S, Uppaluri S, Constable G, Levin S, Stone H, Tarnita C, Brangwynne C. Farming and public goods production in populations. Proc Natl Acad Sci U S A. 2017;114(9):2289–2294. PMCID: PMC5338499
    Reference Link
  • 1.
    Hahm J-H, Kim S, DiLoreto R, Shi C, Lee S-J, Murphy C, Nam H. C. elegans maximum velocity correlates with healthspan and is maintained in worms with an insulin receptor mutation. Nat Commun. 2015;6:8919. PMCID: PMC4656132
    Reference Link
  • 1.
    Uppaluri S, Brangwynne C. A size threshold governs Caenorhabditis elegans developmental progression. Proc Biol Sci. 2015;282(1813):20151283. PMCID: PMC4632629
    Reference Link
  • 1.
    Feric M, Vaidya N, Harmon T, Mitrea D, Zhu L, Richardson T, Kriwacki R, Pappu R, Brangwynne C. Coexisting Liquid Phases Underlie Nucleolar Subcompartments. Cell. 2016;165(7):1686–1697. PMCID: PMC5127388
    Reference Link
  • 1.
    Ghosh R, Bloom J, Mohammadi A, Schumer M, Andolfatto P, Ryu W, Kruglyak L. Genetics of Intraspecies Variation in Avoidance Behavior Induced by a Thermal Stimulus in Caenorhabditis elegans. Genetics. 2015;200(4):1327–39. PMCID: PMC4574258
    Reference Link
  • 1.
    DiLoreto R, Murphy C. The cell biology of aging. Mol Biol Cell. 2015;26(25):4524–31. PMCID: PMC4678010
    Reference Link
  • 1.
    Uppaluri S, Weber S, Brangwynne C. Hierarchical Size Scaling during Multicellular Growth and Development. Cell Rep. 2016;17(2):345–352. PMID: 27705784
    Reference Link
  • 1.
    Mattingly H, Chen J, Arur S, Shvartsman S. A Transport Model for Estimating the Time Course of ERK Activation in the C. elegans Germline. Biophys J. 2015;109(11):2436–45. PMCID: PMC4675862
    Reference Link
  • 1.
    Nguyen J, Shipley F, Linder A, Plummer G, Liu M, Setru S, Shaevitz J, Leifer A. Whole-brain calcium imaging with cellular resolution in freely behaving Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2016;113(8):E1074–81. PMCID: PMC4776509
    Reference Link
  • 1.
    Berry J, Weber S, Vaidya N, Haataja M, Brangwynne C. RNA transcription modulates phase transition-driven nuclear body assembly. Proc Natl Acad Sci U S A. 2015;112(38):E5237–45. PMCID: PMC4586886
    Reference Link
  • 1.
    Kaletsky R, Lakhina V, Arey R, Williams A, Landis J, Ashraf J, Murphy C. The C. elegans adult neuronal IIS/FOXO transcriptome reveals adult phenotype regulators. Nature. 2016;529(7584):92–6. PMCID: PMC4708089
    Reference Link

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