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Biological Products

  • 1.
    Clark K, Covington B, Seyedsayamdost M. Biosynthesis-guided discovery reveals enteropeptins as alternative sactipeptides containing N-methylornithine. Nat Chem. 2022;14(12):1390–1398. PMID: 36316408
    Reference Link
  • 1.
    Han E, Lee S, Hoshino S, Seyedsayamdost M. Targeted Discovery of Cryptic Metabolites with Antiproliferative Activity. ACS Chem Biol. 2022;17(11):3121–3130. PMID: 36228140
    Reference Link
  • 1.
    Clark K, Seyedsayamdost M. Bioinformatic Atlas of Radical SAM Enzyme-Modified RiPP Natural Products Reveals an Isoleucine-Tryptophan Crosslink. J Am Chem Soc. 2022;144(39):17876–17888. PMID: 36128669
    Reference Link
  • 1.
    Kayrouz C, Huang J, Hauser N, Seyedsayamdost M. Biosynthesis of selenium-containing small molecules in diverse microorganisms. Nature. 2022;610(7930):199–204. PMCID: 2881734
    Reference Link
  • 1.
    Li Y, Lee S, Han E, Seyedsayamdost M. Momomycin, an Antiproliferative Cryptic Metabolite from the Oxytetracycline Producer Streptomyces rimosus. Angew Chem Int Ed Engl. 2022;61(39):e202208573. PMCID: PMC9489664
    Reference Link
  • 1.
    Bushin L, Covington B, Clark K, Caruso A, Seyedsayamdost M. Bicyclostreptins are radical SAM enzyme-modified peptides with unique cyclization motifs. Nat Chem Biol. 2022;18(10):1135–1143. PMCID: 6686864
    Reference Link
  • 1.
    Covington B, Seyedsayamdost M. Vitamin B3 Triggers Biosynthesis of Secondary Metabolite Dormancy Signals in . J Am Chem Soc. 2022;144(33):14997–15001. PMID: 35969232
    Reference Link
  • 1.
    Zhang Y, Gallant Étienne, Park J-D, Seyedsayamdost M. The Small-Molecule Language of Dynamic Microbial Interactions. Annu Rev Microbiol. 2022;76:641–660. PMID: 35679616
    Reference Link
  • 1.
    Lee S, Seyedsayamdost M. Induction of Diverse Cryptic Fungal Metabolites by Steroids and Channel Blockers. Angew Chem Int Ed Engl. 2022;61(29):e202204519. PMCID: PMC9276648
    Reference Link
  • 1.
    Covington B, Seyedsayamdost M. Guidelines for metabolomics-guided transposon mutagenesis for microbial natural product discovery. Methods Enzymol. 2022;665:305–323. PMCID: PMC9078877
    Reference Link
  • 1.
    Do T, Link J. Protein Engineering in Ribosomally Synthesized and Post-translationally Modified Peptides (RiPPs). Biochemistry. 2023;62(2):201–209. PMCID: PMC9454058
    Reference Link
  • 1.
    Covington B, Seyedsayamdost M. MetEx, a Metabolomics Explorer Application for Natural Product Discovery. ACS Chem Biol. 2021;16(12):2825–2833. PMCID: PMC9090437
    Reference Link
  • 1.
    Caruso A, Seyedsayamdost M. Radical SAM Enzyme QmpB Installs Two 9-Membered Ring Sactionine Macrocycles during Biogenesis of a Ribosomal Peptide Natural Product. J Org Chem. 2021;86(16):11284–11289. PMID: 34351169
    Reference Link
  • 1.
    Cao L, Do T, Link J. Mechanisms of action of ribosomally synthesized and posttranslationally modified peptides (RiPPs). J Ind Microbiol Biotechnol. 2021;48(3-4). PMCID: PMC8183687
    Reference Link
  • 1.
    Yoshimura A, Covington B, Gallant Étienne, Zhang C, Li A, Seyedsayamdost M. Unlocking Cryptic Metabolites with Mass Spectrometry-Guided Transposon Mutant Selection. ACS Chem Biol. 2020;15(10):2766–2774. PMCID: PMC7572862
    Reference Link
  • 1.
    Covington B, Xu F, Seyedsayamdost M. A Natural Product Chemist’s Guide to Unlocking Silent Biosynthetic Gene Clusters. Annu Rev Biochem. 2021;90:763–788. PMCID: PMC9148385
    Reference Link
  • 1.
    Kloosterman A, Cimermancic P, Elsayed S, Du C, Hadjithomas M, Donia M, Fischbach M, van Wezel G, Medema M. Expansion of RiPP biosynthetic space through integration of pan-genomics and machine learning uncovers a novel class of lanthipeptides. PLoS Biol. 2020;18(12):e3001026. PMCID: PMC7794033
    Reference Link
  • 1.
    Montalbán-López M, Scott T, Ramesh S, Rahman I, van Heel A, Viel J, Bandarian V, Dittmann E, Genilloud O, Goto Y, Burgos M, Hill C, Kim S, Koehnke J, Latham J, Link J, Martínez B, Nair S, Nicolet Y, Rebuffat S, Sahl H-G, Sareen D, Schmidt E, Schmitt L, Severinov K, Süssmuth R, Truman A, Wang H, Weng J-K, van Wezel G, Zhang Q, Zhong J, Piel J, Mitchell D, Kuipers O, van der Donk W. New developments in RiPP discovery, enzymology and engineering. Nat Prod Rep. 2021;38(1):130–239. PMCID: PMC7864896
    Reference Link
  • 1.
    Zhang C, Seyedsayamdost M. Discovery of a Cryptic Depsipeptide from Streptomyces ghanaensis via MALDI-MS-Guided High-Throughput Elicitor Screening. Angew Chem Int Ed Engl. 2020;59(51):23005–23009. PMID: 32790054
    Reference Link
  • 1.
    Seyedsayamdost M, Stallforth P. Special Issue in Honor of Professor Jon Clardy. J Nat Prod. 2020;83(3):565–568. PMID: 32216264
    Reference Link
  • 1.
    Li A, Mao D, Yoshimura A, Rosen P, Martin L, Gallant Étienne, Wühr M, Seyedsayamdost M. Multi-Omic Analyses Provide Links between Low-Dose Antibiotic Treatment and Induction of Secondary Metabolism in Burkholderia thailandensis. mBio. 2020;11(1). PMCID: PMC7042699
    Reference Link
  • 1.
    Greenberg P, Chandler J, Seyedsayamdost M. The Chemistry and Biology of Bactobolin: A 10-Year Collaboration with Natural Product Chemist Extraordinaire Jon Clardy. J Nat Prod. 2020;83(3):738–743. PMCID: PMC8118907
    Reference Link
  • 1.
    Park J-D, Moon K, Miller C, Rose J, Xu F, Ebmeier C, Jacobsen J, Mao D, Old W, DeShazer D, Seyedsayamdost M. Thailandenes, Cryptic Polyene Natural Products Isolated from Using Phenotype-Guided Transposon Mutagenesis. ACS Chem Biol. 2020;15(5):1195–1203. PMCID: PMC9106368
    Reference Link
  • 1.
    Clark K, Bushin L, Seyedsayamdost M. Aliphatic Ether Bond Formation Expands the Scope of Radical SAM Enzymes in Natural Product Biosynthesis. J Am Chem Soc. 2019;141(27):10610–10615. PMID: 31246011
    Reference Link
  • 1.
    Liu M, El-Hossary E, Oelschlaeger T, Donia M, Quinn R, Abdelmohsen U. Potential of marine natural products against drug-resistant bacterial infections. Lancet Infect Dis. 2019;19(7):e237-e245. PMID: 31031171
    Reference Link
  • 1.
    Xu F, Wu Y, Zhang C, Davis K, Moon K, Bushin L, Seyedsayamdost M. A genetics-free method for high-throughput discovery of cryptic microbial metabolites. Nat Chem Biol. 2019;15(2):161–168. PMCID: PMC6339573
    Reference Link
  • 1.
    Seyedsayamdost M. Toward a global picture of bacterial secondary metabolism. J Ind Microbiol Biotechnol. 2019;46(3-4):301–311. PMCID: PMC6779422
    Reference Link
  • 1.
    Tuttle R, Demko A, Patin N, Kapono C, Donia M, Dorrestein P, Jensen P. Detection of Natural Products and Their Producers in Ocean Sediments. Appl Environ Microbiol. 2019;85(8). PMCID: PMC6450032
    Reference Link
  • 1.
    Bushin L, Seyedsayamdost M. Guidelines for Determining the Structures of Radical SAM Enzyme-Catalyzed Modifications in the Biosynthesis of RiPP Natural Products. Methods Enzymol. 2018;606:439–460. PMID: 30097102
    Reference Link
  • 1.
    Wu Y, Seyedsayamdost M. The Polyene Natural Product Thailandamide A Inhibits Fatty Acid Biosynthesis in Gram-Positive and Gram-Negative Bacteria. Biochemistry. 2018;57(29):4247–4251. PMID: 29975047
    Reference Link
  • 1.
    Xu F, Nazari B, Moon K, Bushin L, Seyedsayamdost M. Discovery of a Cryptic Antifungal Compound from Streptomyces albus J1074 Using High-Throughput Elicitor Screens. J Am Chem Soc. 2017;139(27):9203–9212. PMCID: PMC5617735
    Reference Link
  • 1.
    Seyedsayamdost M. High-throughput platform for the discovery of elicitors of silent bacterial gene clusters. Proc Natl Acad Sci U S A. 2014;111(20):7266–71. PMCID: PMC4034229
    Reference Link
  • 1.
    Wang R, Seyedsayamdost M. Roseochelin B, an Algaecidal Natural Product Synthesized by the Roseobacter Phaeobacter inhibens in Response to Algal Sinapic Acid. Org Lett. 2017;19(19):5138–5141. PMID: 28920692
    Reference Link
  • 1.
    Wang B, Muir T. Regulation of Virulence in Staphylococcus aureus: Molecular Mechanisms and Remaining Puzzles. Cell Chem Biol. 2016;23(2):214–224. PMCID: PMC4847544
    Reference Link
  • 1.
    Link J. Biosynthesis: Leading the way to RiPPs. Nat Chem Biol. 2015;11(8):551–2. PMCID: PMC4794250
    Reference Link
  • 1.
    Kwan J, Tianero M, Donia M, Wyche T, Bugni T, Schmidt E. Host control of symbiont natural product chemistry in cryptic populations of the tunicate Lissoclinum patella. PLoS One. 2014;9(5):e95850. PMCID: PMC4008419
    Reference Link
  • 1.
    Donia M, Fischbach M. HUMAN MICROBIOTA. Small molecules from the human microbiota. Science. 2015;349(6246):1254766. PMCID: PMC4641445
    Reference Link

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