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Biocatalysis

  • 1.
    Qian H, Zhao X, Yan R, Yao X, Gao S, Sun X, Du X, Yang H, Wong C, Yan N. Structural basis for catalysis and substrate specificity of human ACAT1. Nature. 2020;581(7808):333–338. PMCID: 5093084
    Reference Link
  • 1.
    Ge E, Jani K, Diehl K, Müller M, Muir T. Nucleation and Propagation of Heterochromatin by the Histone Methyltransferase PRC2: Geometric Constraints and Impact of the Regulatory Subunit JARID2. J Am Chem Soc. 2019;141(38):15029–15039. PMCID: PMC6941475
    Reference Link
  • 1.
    Forneris C, Seyedsayamdost M. In Vitro Reconstitution of OxyC Activity Enables Total Chemoenzymatic Syntheses of Vancomycin Aglycone Variants. Angew Chem Int Ed Engl. 2018;57(27):8048–8052. PMID: 29697176
    Reference Link
  • 1.
    Bushin L, Seyedsayamdost M. Guidelines for Determining the Structures of Radical SAM Enzyme-Catalyzed Modifications in the Biosynthesis of RiPP Natural Products. Methods Enzymol. 2018;606:439–460. PMID: 30097102
    Reference Link
  • 1.
    Schramma K, Bushin L, Seyedsayamdost M. Structure and biosynthesis of a macrocyclic peptide containing an unprecedented lysine-to-tryptophan crosslink. Nat Chem. 2015;7(5):431–437. PMCID: PMC4443489
    Reference Link
  • 1.
    Morscher R, Ducker G, Li S, Mayer J, Gitai Z, Sperl W, Rabinowitz J. Mitochondrial translation requires folate-dependent tRNA methylation. Nature. 2018;554(7690):128–132. PMCID: PMC6020024
    Reference Link
  • 1.
    Digianantonio K, Korolev M, Hecht M. A Non-natural Protein Rescues Cells Deleted for a Key Enzyme in Central Metabolism. ACS Synth Biol. 2017;6(4):694–700. PMID: 28055179
    Reference Link
  • 1.
    Robinson J, Brynildsen M. An ensemble-guided approach identifies ClpP as a major regulator of transcript levels in nitric oxide-stressed Escherichia coli. Metab Eng. 2015;31:22–34. PMID: 26112956
    Reference Link
  • 1.
    Maksimov M, Koos J, Zong C, Lisko B, Link J. Elucidating the Specificity Determinants of the AtxE2 Lasso Peptide Isopeptidase. J Biol Chem. 2015;290(52):30806–12. PMCID: PMC4692210
    Reference Link
  • 1.
    Digianantonio K, Hecht M. A protein constructed de novo enables cell growth by altering gene regulation. Proc Natl Acad Sci U S A. 2016;113(9):2400–5. PMCID: PMC4780649
    Reference Link
  • 1.
    Donovan J, Dufner M, Korennykh A. Structural basis for cytosolic double-stranded RNA surveillance by human oligoadenylate synthetase 1. Proc Natl Acad Sci U S A. 2013;110(5):1652–7. PMCID: PMC3562804
    Reference Link
  • 1.
    Purdy J, Shenk T, Rabinowitz J. Fatty acid elongase 7 catalyzes lipidome remodeling essential for human cytomegalovirus replication. Cell Rep. 2015;10(8):1375–85. PMCID: PMC4354725
    Reference Link

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