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Bacterial Proteins

  • 1.
    Islam S, Jolivet N, Cuzin C, Belgrave A, My L, Fleuchot B, Faure L, Mahanta U, Kezzo A, Saïdi F, Sharma G, Fiche J-B, Bratton B, Herrou J, Nollmann M, Shaevitz J, Durand E, Mignot T. Unmasking of the von Willebrand A-domain surface adhesin CglB at bacterial focal adhesions mediates myxobacterial gliding motility. Sci Adv. 2023;9(8):eabq0619. PMCID: PMC9946355
    Reference Link
  • 1.
    Ellison C, Fei C, Dalia T, Wingreen N, Dalia A, Shaevitz J, Gitai Z. Subcellular localization of type IV pili regulates bacterial multicellular development. Nat Commun. 2022;13(1):6334. PMCID: PMC9596432
    Reference Link
  • 1.
    Clark K, Covington B, Seyedsayamdost M. Biosynthesis-guided discovery reveals enteropeptins as alternative sactipeptides containing N-methylornithine. Nat Chem. 2022;14(12):1390–1398. PMID: 36316408
    Reference Link
  • 1.
    Prentice J, Bridges A, Bassler B. Synergy between c-di-GMP and Quorum-Sensing Signaling in Vibrio cholerae Biofilm Morphogenesis. J Bacteriol. 2022;204(10):e0024922. PMCID: PMC9578409
    Reference Link
  • 1.
    Mashruwala A, Qin B, Bassler B. Quorum-sensing- and type VI secretion-mediated spatiotemporal cell death drives genetic diversity in Vibrio cholerae. Cell. 2022;185(21):3966–3979.e13. PMCID: PMC9623500
    Reference Link
  • 1.
    Qin B, Bassler B. Quorum-sensing control of matrix protein production drives fractal wrinkling and interfacial localization of Vibrio cholerae pellicles. Nat Commun. 2022;13(1):6063. PMCID: PMC9561665
    Reference Link
  • 1.
    Taylor I, Murray-Nerger L, Greco T, Liu D, Cristea I, Bassler B. Protein Interaction Networks of Catalytically Active and Catalytically Inactive PqsE in Pseudomonas aeruginosa. mBio. 2022;13(5):e0155922. PMCID: PMC9600345
    Reference Link
  • 1.
    Landajuela A, Braun M, Martínez-Calvo A, Rodrigues C, Perez C, Doan T, Rudner D, Wingreen N, Karatekin E. Membrane fission during bacterial spore development requires cellular inflation driven by DNA translocation. Curr Biol. 2022;32(19):4186–4200.e8. PMCID: PMC9730832
    Reference Link
  • 1.
    Zhao A, Bodine S, Xie Q, Wang B, Ram G, Novick R, Muir T. Reconstitution of the quorum sensing pathway reveals a direct role for the integral membrane protease MroQ in pheromone biosynthesis. Proc Natl Acad Sci U S A. 2022;119(33):e2202661119. PMCID: PMC9388083
    Reference Link
  • 1.
    Bushin L, Covington B, Clark K, Caruso A, Seyedsayamdost M. Bicyclostreptins are radical SAM enzyme-modified peptides with unique cyclization motifs. Nat Chem Biol. 2022;18(10):1135–1143. PMCID: 6686864
    Reference Link
  • 1.
    Taylor I, Jeffrey P, Moustafa D, Goldberg J, Bassler B. The PqsE Active Site as a Target for Small Molecule Antimicrobial Agents against . Biochemistry. 2022;61(17):1894–1903. PMCID: PMC9454246
    Reference Link
  • 1.
    Bridges A, Prentice J, Wingreen N, Bassler B. Signal Transduction Network Principles Underlying Bacterial Collective Behaviors. Annu Rev Microbiol. 2022;76:235–257. PMCID: PMC9463083
    Reference Link
  • 1.
    Høyland-Kroghsbo N, Bassler B. Phage Infection Restores PQS Signaling and Enhances Growth of a Pseudomonas aeruginosa Quorum-Sensing Mutant. J Bacteriol. 2022;204(5):e0055721. PMCID: PMC9112912
    Reference Link
  • 1.
    Eickhoff M, Fei C, Cong J-P, Bassler B. LuxT Is a Global Regulator of Low-Cell-Density Behaviors, Including Type III Secretion, Siderophore Production, and Aerolysin Production, in Vibrio harveyi. mBio. 2022;13(1):e0362121. PMCID: PMC8764538
    Reference Link
  • 1.
    Simanek K, Taylor I, Richael E, Lasek-Nesselquist E, Bassler B, Paczkowski J. The PqsE-RhlR Interaction Regulates RhlR DNA Binding to Control Virulence Factor Production in . Microbiol Spectr. 2022;10(1):e0210821. PMCID: PMC8754118
    Reference Link
  • 1.
    Martin N, Blackman E, Bratton B, Chase K, Bartlett T, Gitai Z. CrvA and CrvB form a curvature-inducing module sufficient to induce cell-shape complexity in Gram-negative bacteria. Nat Microbiol. 2021;6(7):910–920. PMCID: PMC8764749
    Reference Link
  • 1.
    Landajuela A, Braun M, Rodrigues C, Martínez-Calvo A, Doan T, Horenkamp F, Andronicos A, Shteyn V, Williams N, Lin C, Wingreen N, Rudner D, Karatekin E. FisB relies on homo-oligomerization and lipid binding to catalyze membrane fission in bacteria. PLoS Biol. 2021;19(6):e3001314. PMCID: PMC8274934
    Reference Link
  • 1.
    Balo A, Caruso A, Tao L, Tantillo D, Seyedsayamdost M, Britt D. Trapping a cross-linked lysine-tryptophan radical in the catalytic cycle of the radical SAM enzyme SuiB. Proc Natl Acad Sci U S A. 2021;118(21). PMCID: PMC8166192
    Reference Link
  • 1.
    Narla A, Borenstein D, Wingreen N. A biophysical limit for quorum sensing in biofilms. Proc Natl Acad Sci U S A. 2021;118(21). PMCID: PMC8166027
    Reference Link
  • 1.
    Valastyan J, Kraml C, Pelczer I, Ferrante T, Bassler B. Saccharomyces cerevisiae Requires To Produce 4-Hydroxy-5-Methylfuran-3(2H)-One, a Mimic of the Bacterial Quorum-Sensing Autoinducer AI-2. mBio. 2021;12(2). PMCID: PMC8092285
    Reference Link
  • 1.
    Eickhoff M, Fei C, Huang X, Bassler B. LuxT controls specific quorum-sensing-regulated behaviors in Vibrionaceae spp. via repression of qrr1, encoding a small regulatory RNA. PLoS Genet. 2021;17(4):e1009336. PMCID: PMC8043402
    Reference Link
  • 1.
    Bridges A, Bassler B. Inverse regulation of biofilm dispersal by polyamine signals. Elife. 2021;10. PMCID: PMC8079147
    Reference Link
  • 1.
    Prior M, Selvanayagam J, Kim J-G, Tomar M, Jonikas M, Mudgett M, Smeekens S, Hanson J, Frommer W. bZIP11 Is a Susceptibility Factor During Infection. Mol Plant Microbe Interact. 2021;34(4):439–447. PMID: 33400562
    Reference Link
  • 1.
    Bridges A, Fei C, Bassler B. Identification of signaling pathways, matrix-digestion enzymes, and motility components controlling biofilm dispersal. Proc Natl Acad Sci U S A. 2020;117(51):32639–32647. PMCID: PMC7768729
    Reference Link
  • 1.
    Vrla G, Esposito M, Zhang C, Kang Y, Seyedsayamdost M, Gitai Z. Cytotoxic alkyl-quinolones mediate surface-induced virulence in Pseudomonas aeruginosa. PLoS Pathog. 2020;16(9):e1008867. PMCID: PMC7515202
    Reference Link
  • 1.
    Xie Q, Wiedmann M, Zhao A, Pagan I, Novick R, Suga H, Muir T. Discovery of quorum quenchers targeting the membrane-embedded sensor domain of the receptor histidine kinase, AgrC. Chem Commun (Camb). 2020;56(76):11223–11226. PMCID: PMC7530097
    Reference Link
  • 1.
    Mashruwala A, Bassler B. The Vibrio cholerae Quorum-Sensing Protein VqmA Integrates Cell Density, Environmental, and Host-Derived Cues into the Control of Virulence. mBio. 2020;11(4). PMCID: PMC7387800
    Reference Link
  • 1.
    Gao S, Valinsky W, On N, Houlihan P, Qu Q, Liu L, Pan X, Clapham D, Yan N. Employing NaChBac for cryo-EM analysis of toxin action on voltage-gated Na channels in nanodisc. Proc Natl Acad Sci U S A. 2020;117(25):14187–14193. PMCID: PMC7322032
    Reference Link
  • 1.
    Mukherjee S, Jemielita M, Stergioula V, Tikhonov M, Bassler B. Photosensing and quorum sensing are integrated to control Pseudomonas aeruginosa collective behaviors. PLoS Biol. 2019;17(12):e3000579. PMCID: PMC6932827
    Reference Link
  • 1.
    Taylor J, Bratton B, Sichel S, Blair K, Jacobs H, DeMeester K, Kuru E, Gray J, Biboy J, VanNieuwenhze M, Vollmer W, Grimes C, Shaevitz J, Salama N. Distinct cytoskeletal proteins define zones of enhanced cell wall synthesis in . Elife. 2020;9. PMCID: PMC7012605
    Reference Link
  • 1.
    Jemielita M, Wingreen N, Bassler B. Quorum sensing controls multicellular aggregate formation. Elife. 2018;7. PMCID: PMC6351105
    Reference Link
  • 1.
    McCready A, Paczkowski J, Henke B, Bassler B. Structural determinants driving homoserine lactone ligand selection in the LasR quorum-sensing receptor. Proc Natl Acad Sci U S A. 2019;116(1):245–254. PMCID: PMC6320529
    Reference Link
  • 1.
    Qin B, Fei C, Bridges A, Mashruwala A, Stone H, Wingreen N, Bassler B. Cell position fates and collective fountain flow in bacterial biofilms revealed by light-sheet microscopy. Science. 2020;369(6499):71–77. PMCID: PMC7426073
    Reference Link
  • 1.
    Myhrvold C, Freije C, Gootenberg J, Abudayyeh O, Metsky H, Durbin A, Kellner M, Tan A, Paul L, Parham L, Garcia K, Barnes K, Chak B, Mondini A, Nogueira M, Isern S, Michael S, Lorenzana I, Yozwiak N, MacInnis B, Bosch I, Gehrke L, Zhang F, Sabeti P. Field-deployable viral diagnostics using CRISPR-Cas13. Science. 2018;360(6387):444–448. PMCID: PMC6197056
    Reference Link
  • 1.
    Caruso A, Bushin L, Clark K, Martinie R, Seyedsayamdost M. Radical Approach to Enzymatic β-Thioether Bond Formation. J Am Chem Soc. 2019;141(2):990–997. PMID: 30521328
    Reference Link
  • 1.
    Werner J, Shi H, Hsin J, Huang K, Gitai Z, Klein E. AimB Is a Small Protein Regulator of Cell Size and MreB Assembly. Biophys J. 2020;119(3):593–604. PMCID: PMC7399478
    Reference Link
  • 1.
    Eickhoff M, Bassler B. Vibrio fischeri siderophore production drives competitive exclusion during dual-species growth. Mol Microbiol. 2020;114(2):244–261. PMCID: PMC7541421
    Reference Link
  • 1.
    Zhang C, Seyedsayamdost M. CanE, an Iron/2-Oxoglutarate-Dependent Lasso Peptide Hydroxylase from . ACS Chem Biol. 2020;15(4):890–894. PMID: 32191027
    Reference Link
  • 1.
    Li A, Mao D, Yoshimura A, Rosen P, Martin L, Gallant Étienne, Wühr M, Seyedsayamdost M. Multi-Omic Analyses Provide Links between Low-Dose Antibiotic Treatment and Induction of Secondary Metabolism in Burkholderia thailandensis. mBio. 2020;11(1). PMCID: PMC7042699
    Reference Link
  • 1.
    Valastyan J, Tota M, Taylor I, Stergioula V, Hone G, Smith C, Henke B, Carson K, Bassler B. Discovery of PqsE Thioesterase Inhibitors for Using DNA-Encoded Small Molecule Library Screening. ACS Chem Biol. 2020;15(2):446–456. PMCID: PMC7036018
    Reference Link
  • 1.
    Mao D, Yoshimura A, Wang R, Seyedsayamdost M. Reporter-Guided Transposon Mutant Selection for Activation of Silent Gene Clusters in Burkholderia thailandensis. Chembiochem. 2020;21(13):1826–1831. PMCID: PMC7493819
    Reference Link
  • 1.
    Huang X, Duddy O, Silpe J, Paczkowski J, Cong J, Henke B, Bassler B. Mechanism underlying autoinducer recognition in the DPO-VqmA quorum-sensing pathway. J Biol Chem. 2020;295(10):2916–2931. PMCID: PMC7062168
    Reference Link
  • 1.
    Bushin L, Clark K, Pelczer I, Seyedsayamdost M. Charting an Unexplored Streptococcal Biosynthetic Landscape Reveals a Unique Peptide Cyclization Motif. J Am Chem Soc. 2018;140(50):17674–17684. PMID: 30398325
    Reference Link
  • 1.
    Bridges A, Bassler B. The intragenus and interspecies quorum-sensing autoinducers exert distinct control over Vibrio cholerae biofilm formation and dispersal. PLoS Biol. 2019;17(11):e3000429. PMCID: PMC6872173
    Reference Link
  • 1.
    Chuang S, Vrla G, Fröhlich K, Gitai Z. Surface association sensitizes Pseudomonas aeruginosa to quorum sensing. Nat Commun. 2019;10(1):4118. PMCID: PMC6739362
    Reference Link
  • 1.
    Mitchell A, Silhavy T. Envelope stress responses: balancing damage repair and toxicity. Nat Rev Microbiol. 2019;17(7):417–428. PMCID: PMC6596312
    Reference Link
  • 1.
    Clark K, Bushin L, Seyedsayamdost M. Aliphatic Ether Bond Formation Expands the Scope of Radical SAM Enzymes in Natural Product Biosynthesis. J Am Chem Soc. 2019;141(27):10610–10615. PMID: 31246011
    Reference Link
  • 1.
    McCready A, Paczkowski J, Cong J-P, Bassler B. An autoinducer-independent RhlR quorum-sensing receptor enables analysis of RhlR regulation. PLoS Pathog. 2019;15(6):e1007820. PMCID: PMC6564026
    Reference Link
  • 1.
    Xie Q, Zhao A, Jeffrey P, Kim M, Bassler B, Stone H, Novick R, Muir T. Identification of a Molecular Latch that Regulates Staphylococcal Virulence. Cell Chem Biol. 2019;26(4):548–558.e4. PMCID: PMC6506218
    Reference Link
  • 1.
    Paczkowski J, McCready A, Cong J-P, Li Z, Jeffrey P, Smith C, Henke B, Hughson F, Bassler B. An Autoinducer Analogue Reveals an Alternative Mode of Ligand Binding for the LasR Quorum-Sensing Receptor. ACS Chem Biol. 2019;14(3):378–389. PMCID: PMC6601336
    Reference Link

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