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Bacterial Outer Membrane Proteins

  • 1.
    Guest R, Silhavy T. Cracking outer membrane biogenesis. Biochim Biophys Acta Mol Cell Res. 2023;1870(2):119405. PMCID: PMC9878550
    Reference Link
  • 1.
    Sun J, Rutherford S, Silhavy T, Huang K. Physical properties of the bacterial outer membrane. Nat Rev Microbiol. 2022;20(4):236–248. PMCID: PMC8934262
    Reference Link
  • 1.
    Doyle M, Jimah J, Dowdy T, Ohlemacher S, Larion M, Hinshaw J, Bernstein H. Cryo-EM structures reveal multiple stages of bacterial outer membrane protein folding. Cell. 2022;185(7):1143–1156.e13. PMCID: PMC8985213
    Reference Link
  • 1.
    Benn G, Mikheyeva I, Inns P, Forster J, Ojkic N, Bortolini C, Ryadnov M, Kleanthous C, Silhavy T, Hoogenboom B. Phase separation in the outer membrane of . Proc Natl Acad Sci U S A. 2021;118(44). PMCID: PMC8612244
    Reference Link
  • 1.
    Combs A, Silhavy T. The sacrificial adaptor protein Skp functions to remove stalled substrates from the β-barrel assembly machine. Proc Natl Acad Sci U S A. 2022;119(1). PMCID: PMC8740687
    Reference Link
  • 1.
    Guest R, Rutherford S, Silhavy T. Border Control: Regulating LPS Biogenesis. Trends Microbiol. 2021;29(4):334–345. PMCID: PMC7969359
    Reference Link
  • 1.
    Hart E, Silhavy T. Functions of the BamBCDE Lipoproteins Revealed by Bypass Mutations in BamA. J Bacteriol. 2020;202(21). PMCID: PMC7549358
    Reference Link
  • 1.
    Hart E, Gupta M, Wühr M, Silhavy T. The gain-of-function allele bypasses the essential requirement for BamD in β-barrel outer membrane protein assembly. Proc Natl Acad Sci U S A. 2020;117(31):18737–18743. PMCID: PMC7414184
    Reference Link
  • 1.
    Taylor J, Bratton B, Sichel S, Blair K, Jacobs H, DeMeester K, Kuru E, Gray J, Biboy J, VanNieuwenhze M, Vollmer W, Grimes C, Shaevitz J, Salama N. Distinct cytoskeletal proteins define zones of enhanced cell wall synthesis in . Elife. 2020;9. PMCID: PMC7012605
    Reference Link
  • 1.
    Guest R, Guerra D, Wissler M, Grimm J, Silhavy T. YejM Modulates Activity of the YciM/FtsH Protease Complex To Prevent Lethal Accumulation of Lipopolysaccharide. mBio. 2020;11(2). PMCID: PMC7157816
    Reference Link
  • 1.
    Eickhoff M, Bassler B. Vibrio fischeri siderophore production drives competitive exclusion during dual-species growth. Mol Microbiol. 2020;114(2):244–261. PMCID: PMC7541421
    Reference Link
  • 1.
    Hart E, Mitchell A, Konovalova A, Grabowicz M, Sheng J, Han X, Rodriguez-Rivera F, Schwaid A, Malinverni J, Balibar C, Bodea S, Si Q, Wang H, Homsher M, Painter R, Ogawa A, Sutterlin H, Roemer T, Black T, Rothman D, Walker S, Silhavy T. A small-molecule inhibitor of BamA impervious to efflux and the outer membrane permeability barrier. Proc Natl Acad Sci U S A. 2019;116(43):21748–21757. PMCID: PMC6815139
    Reference Link
  • 1.
    Hart E, Gupta M, Wühr M, Silhavy T. The Synthetic Phenotype of Δ Δ Double Mutants Results from a Lethal Jamming of the Bam Complex by the Lipoprotein RcsF. mBio. 2019;10(3). PMCID: PMC6529638
    Reference Link
  • 1.
    Ricci D, Silhavy T. Outer Membrane Protein Insertion by the β-barrel Assembly Machine. EcoSal Plus. 2019;8(2). PMCID: PMC6419762
    Reference Link
  • 1.
    Hart E, O’Connell A, Tang K, Wzorek J, Grabowicz M, Kahne D, Silhavy T. Fine-Tuning of σ Activation Suppresses Multiple Assembly-Defective Mutations in Escherichia coli. J Bacteriol. 2019;201(11). PMCID: PMC6509652
    Reference Link
  • 1.
    Mitchell A, Srikumar T, Silhavy T. Cyclic Enterobacterial Common Antigen Maintains the Outer Membrane Permeability Barrier of Escherichia coli in a Manner Controlled by YhdP. mBio. 2018;9(4). PMCID: PMC6083912
    Reference Link
  • 1.
    Konovalova A, Grabowicz M, Balibar C, Malinverni J, Painter R, Riley D, Mann P, Wang H, Garlisi C, Sherborne B, Rigel N, Ricci D, Black T, Roemer T, Silhavy T, Walker S. Inhibitor of intramembrane protease RseP blocks the σ response causing lethal accumulation of unfolded outer membrane proteins. Proc Natl Acad Sci U S A. 2018;115(28):E6614-E6621. PMCID: PMC6048503
    Reference Link
  • 1.
    May K, Silhavy T. The Phospholipase PldA Regulates Outer Membrane Homeostasis via Lipid Signaling. mBio. 2018;9(2). PMCID: PMC5874903
    Reference Link
  • 1.
    Lee J, Sutterlin H, Wzorek J, Mandler M, Hagan C, Grabowicz M, Tomasek D, May M, Hart E, Silhavy T, Kahne D. Substrate binding to BamD triggers a conformational change in BamA to control membrane insertion. Proc Natl Acad Sci U S A. 2018;115(10):2359–2364. PMCID: PMC5877925
    Reference Link
  • 1.
    Konovalova A, Kahne D, Silhavy T. Outer Membrane Biogenesis. Annu Rev Microbiol. 2017;71:539–556. PMCID: PMC5778897
    Reference Link
  • 1.
    McCabe A, Ricci D, Adetunji M, Silhavy T. Conformational Changes That Coordinate the Activity of BamA and BamD Allowing β-Barrel Assembly. J Bacteriol. 2017;199(20). PMCID: PMC5637172
    Reference Link
  • 1.
    Soltes G, Martin N, Park E, Sutterlin H, Silhavy T. Distinctive Roles for Periplasmic Proteases in the Maintenance of Essential Outer Membrane Protein Assembly. J Bacteriol. 2017;199(20). PMCID: PMC5637175
    Reference Link
  • 1.
    Sacco S, Adolfsen K, Brynildsen M. An integrated network analysis identifies how ArcAB enables metabolic oscillations in the nitric oxide detoxification network of Escherichia coli. Biotechnol J. 2017;12(8). PMID: 28449226
    Reference Link
  • 1.
    Grabowicz M, Silhavy T. Redefining the essential trafficking pathway for outer membrane lipoproteins. Proc Natl Acad Sci U S A. 2017;114(18):4769–4774. PMCID: PMC5422772
    Reference Link
  • 1.
    Okuda S, Sherman D, Silhavy T, Ruiz N, Kahne D. Lipopolysaccharide transport and assembly at the outer membrane: the PEZ model. Nat Rev Microbiol. 2016;14(6):337–45. PMCID: PMC4937791
    Reference Link
  • 1.
    Mahoney T, Ricci D, Silhavy T. Classifying β-Barrel Assembly Substrates by Manipulating Essential Bam Complex Members. J Bacteriol. 2016;198(14):1984–92. PMCID: PMC4936103
    Reference Link
  • 1.
    Konovalova A, Mitchell A, Silhavy T. A lipoprotein/β-barrel complex monitors lipopolysaccharide integrity transducing information across the outer membrane. Elife. 2016;5. PMCID: PMC4942254
    Reference Link
  • 1.
    Konovalova A, Schwalm J, Silhavy T. A Suppressor Mutation That Creates a Faster and More Robust σE Envelope Stress Response. J Bacteriol. 2016;198(17):2345–51. PMCID: PMC4984553
    Reference Link
  • 1.
    Konovalova A, Silhavy T. Outer membrane lipoprotein biogenesis: Lol is not the end. Philos Trans R Soc Lond B Biol Sci. 2015;370(1679). PMCID: PMC4632606
    Reference Link
  • 1.
    Grabowicz M, Yeh J, Silhavy T. Dominant negative lptE mutation that supports a role for LptE as a plug in the LptD barrel. J Bacteriol. 2013;195(6):1327–34. PMCID: PMC3591993
    Reference Link
  • 1.
    Lee J, Xue M, Wzorek J, Wu T, Grabowicz M, Gronenberg L, Sutterlin H, Davis R, Ruiz N, Silhavy T, Kahne D. Characterization of a stalled complex on the β-barrel assembly machine. Proc Natl Acad Sci U S A. 2016;113(31):8717–22. PMCID: PMC4978274
    Reference Link
  • 1.
    Soltes G, Schwalm J, Ricci D, Silhavy T. The Activity of Escherichia coli Chaperone SurA Is Regulated by Conformational Changes Involving a Parvulin Domain. J Bacteriol. 2016;198(6):921–9. PMCID: PMC4772605
    Reference Link
  • 1.
    Sutterlin H, Shi H, May K, Miguel A, Khare S, Huang K, Silhavy T. Disruption of lipid homeostasis in the Gram-negative cell envelope activates a novel cell death pathway. Proc Natl Acad Sci U S A. 2016;113(11):E1565–74. PMCID: PMC4801249
    Reference Link

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