Clark K, Covington B, Seyedsayamdost M. Biosynthesis-guided discovery reveals enteropeptins as alternative sactipeptides containing N-methylornithine. Nat Chem. 2022;14(12):1390–1398. PMID: 36316408

Elashal H, Koos J, Cheung-Lee W, Choi B, Cao L, Richardson M, White H, Link J. Biosynthesis and characterization of fuscimiditide, an aspartimidylated graspetide. Nat Chem. 2022;14(11):1325–1334. PMCID: PMC10078976

Behnke M, Khan A, Lauron E, Jimah J, Wang Q, Tolia N, Sibley D. Rhoptry Proteins ROP5 and ROP18 Are Major Murine Virulence Factors in Genetically Divergent South American Strains of Toxoplasma gondii. PLoS Genet. 2015;11(8):e1005434. PMCID: PMC4546408

Zhang R, Lee D, Jimah J, Gerassimov N, Yang C, Kim S, Luvsanjav D, Winkelman J, Mettlen M, Abrams M, Kalia R, Keene P, Pandey P, Ravaux B, Kim J, Ditlev J, Zhang G, Rosen M, Frost A, Alto N, Gardel M, Schmid S, Svitkina T, Hinshaw J, Chen E. Dynamin regulates the dynamics and mechanical strength of the actin cytoskeleton as a multifilament actin-bundling protein. Nat Cell Biol. 2020;22(6):674–688. PMCID: PMC7953826

Caruso A, Seyedsayamdost M. Radical SAM Enzyme QmpB Installs Two 9-Membered Ring Sactionine Macrocycles during Biogenesis of a Ribosomal Peptide Natural Product. J Org Chem. 2021;86(16):11284–11289. PMID: 34351169

Schröder H, Zhang Y, Link J. Dynamic covalent self-assembly of mechanically interlocked molecules solely made from peptides. Nat Chem. 2021;13(9):850–857. PMCID: PMC8446321

Huang J, Yuan Y, Zhao N, Pu D, Tang Q, Zhang S, Luo S, Yang X, Wang N, Xiao Y, Zhang T, Liu Z, Sakata-Kato T, Jiang X, Kato N, Yan N, Yin H. Orthosteric-allosteric dual inhibitors of PfHT1 as selective antimalarial agents. Proc Natl Acad Sci U S A. 2021;118(3). PMCID: PMC7826358

Jiang X, Yuan Y, Huang J, Zhang S, Luo S, Wang N, Pu D, Zhao N, Tang Q, Hirata K, Yang X, Jiao Y, Sakata-Kato T, Wu J-W, Yan C, Kato N, Yin H, Yan N. Structural Basis for Blocking Sugar Uptake into the Malaria Parasite Plasmodium falciparum. Cell. 2020;183(1):258–268.e12. PMID: 32860739

Qian H, Wu X, Du X, Yao X, Zhao X, Lee J, Yang H, Yan N. Structural Basis of Low-pH-Dependent Lysosomal Cholesterol Egress by NPC1 and NPC2. Cell. 2020;182(1):98–111.e18. PMID: 32544384

Caruso A, Bushin L, Clark K, Martinie R, Seyedsayamdost M. Radical Approach to Enzymatic β-Thioether Bond Formation. J Am Chem Soc. 2019;141(2):990–997. PMID: 30521328

Cheung-Lee W, Cao L, Link J. Pandonodin: A Proteobacterial Lasso Peptide with an Exceptionally Long C-Terminal Tail. ACS Chem Biol. 2019;14(12):2783–2792. PMCID: PMC7010350

Zhao Y, Huang G, Wu J, Wu Q, Gao S, Yan Z, Lei J, Yan N. Molecular Basis for Ligand Modulation of a Mammalian Voltage-Gated Ca Channel. Cell. 2019;177(6):1495–1506.e12. PMID: 31150622

Zhang C, Seyedsayamdost M. CanE, an Iron/2-Oxoglutarate-Dependent Lasso Peptide Hydroxylase from . ACS Chem Biol. 2020;15(4):890–894. PMID: 32191027

Seo K, Kleiner R. YTHDF2 Recognition of N-Methyladenosine (mA)-Modified RNA Is Associated with Transcript Destabilization. ACS Chem Biol. 2020;15(1):132–139. PMCID: PMC7025767

Valencia A, Collings C, Dao H, St Pierre R, Cheng Y-C, Huang J, Sun Z-Y, Seo H-S, Mashtalir N, Comstock D, Bolonduro O, Vangos N, Yeoh Z, Dornon M, Hermawan C, Barrett L, Dhe-Paganon S, Woolf C, Muir T, Kadoch C. Recurrent SMARCB1 Mutations Reveal a Nucleosome Acidic Patch Interaction Site That Potentiates mSWI/SNF Complex Chromatin Remodeling. Cell. 2019;179(6):1342–1356.e23. PMCID: PMC7175411

Zhao Y, Huang G, Wu Q, Wu K, Li R, Lei J, Pan X, Yan N. Cryo-EM structures of apo and antagonist-bound human Ca3.1. Nature. 2019;576(7787):492–497. PMCID: 18083096

Bushin L, Clark K, Pelczer I, Seyedsayamdost M. Charting an Unexplored Streptococcal Biosynthetic Landscape Reveals a Unique Peptide Cyclization Motif. J Am Chem Soc. 2018;140(50):17674–17684. PMID: 30398325

Caruso A, Martinie R, Bushin L, Seyedsayamdost M. Macrocyclization via an Arginine-Tyrosine Crosslink Broadens the Reaction Scope of Radical -Adenosylmethionine Enzymes. J Am Chem Soc. 2019;141(42):16610–16614. PMID: 31596076

Stevens A, Sekar G, Gramespacher J, Cowburn D, Muir T. An Atypical Mechanism of Split Intein Molecular Recognition and Folding. J Am Chem Soc. 2018;140(37):11791–11799. PMCID: PMC7232844

Clark K, Bushin L, Seyedsayamdost M. Aliphatic Ether Bond Formation Expands the Scope of Radical SAM Enzymes in Natural Product Biosynthesis. J Am Chem Soc. 2019;141(27):10610–10615. PMID: 31246011

Wang S-W, Bitbol A-F, Wingreen N. Revealing evolutionary constraints on proteins through sequence analysis. PLoS Comput Biol. 2019;15(4):e1007010. PMCID: PMC6502352

Jiao J, He M, Port S, Baker R, Xu Y, Qu H, Xiong Y, Wang Y, Jin H, Eisemann T, Hughson F, Zhang Y. Munc18-1 catalyzes neuronal SNARE assembly by templating SNARE association. Elife. 2018;7. PMCID: PMC6320071

Carabetta V, Greco T, Cristea I, Dubnau D. YfmK is an N-lysine acetyltransferase that directly acetylates the histone-like protein HBsu in . Proc Natl Acad Sci U S A. 2019;116(9):3752–3757. PMCID: PMC6397556

Shen H, Liu D, Wu K, Lei J, Yan N. Structures of human Na1.7 channel in complex with auxiliary subunits and animal toxins. Science. 2019;363(6433):1303–1308. PMID: 30765606

Pan X, Li Z, Huang X, Huang G, Gao S, Shen H, Liu L, Lei J, Yan N. Molecular basis for pore blockade of human Na channel Na1.2 by the μ-conotoxin KIIIA. Science. 2019;363(6433):1309–1313. PMID: 30765605

Pan X, Li Z, Zhou Q, Shen H, Wu K, Huang X, Chen J, Zhang J, Zhu X, Lei J, Xiong W, Gong H, Xiao B, Yan N. Structure of the human voltage-gated sodium channel Na1.4 in complex with β1. Science. 2018;362(6412). PMID: 30190309

Shen H, Li Z, Jiang Y, Pan X, Wu J, Cristofori-Armstrong B, Smith J, K Y Chin Y, Lei J, Zhou Q, King G, Yan N. Structural basis for the modulation of voltage-gated sodium channels by animal toxins. Science. 2018;362(6412). PMID: 30049784

Piscotta F, Jeffrey P, Link J. ParST is a widespread toxin-antitoxin module that targets nucleotide metabolism. Proc Natl Acad Sci U S A. 2019;116(3):826–834. PMCID: PMC6338849

Ciccia A, Nimonkar A, Hu Y, Hajdu I, Achar Y, Izhar L, Petit S, Adamson B, Yoon J, Kowalczykowski S, Livingston D, Haracska L, Elledge S. Polyubiquitinated PCNA recruits the ZRANB3 translocase to maintain genomic integrity after replication stress. Mol Cell. 2012;47(3):396–409. PMCID: PMC3613862

Munro D, Ghersi D, Singh M. Two critical positions in zinc finger domains are heavily mutated in three human cancer types. PLoS Comput Biol. 2018;14(6):e1006290. PMCID: PMC6040777

Wojcik F, Dann G, Beh L, Debelouchina G, Hofmann R, Muir T. Functional crosstalk between histone H2B ubiquitylation and H2A modifications and variants. Nat Commun. 2018;9(1):1394. PMCID: PMC5895630

Schramma K, Seyedsayamdost M. Lysine-Tryptophan-Crosslinked Peptides Produced by Radical SAM Enzymes in Pathogenic Streptococci. ACS Chem Biol. 2017;12(4):922–927. PMID: 28191919

Schramma K, Forneris C, Caruso A, Seyedsayamdost M. Mechanistic Investigations of Lysine-Tryptophan Cross-Link Formation Catalyzed by Streptococcal Radical S-Adenosylmethionine Enzymes. Biochemistry. 2018;57(4):461–468. PMID: 29320164

Bradley L, Kleiner R, Wang A, Hecht M, Wood D. An intein-based genetic selection allows the construction of a high-quality library of binary patterned de novo protein sequences. Protein Eng Des Sel. 2005;18(4):201–7. PMID: 15849217

Zong C, Cheung-Lee W, Elashal H, Raj M, Link J. Albusnodin: an acetylated lasso peptide from Streptomyces albus. Chem Commun (Camb). 2018;54(11):1339–1342. PMCID: PMC5835390

Hecht M, Zarzhitsky S, Karas C, Chari S. Are natural proteins special? Can we do that?. Curr Opin Struct Biol. 2018;48:124–132. PMID: 29306103

Gramespacher J, Stevens A, Thompson R, Muir T. Improved protein splicing using embedded split inteins. Protein Sci. 2018;27(3):614–619. PMCID: PMC5818749

Yan Z, Zhou Q, Wang L, Wu J, Zhao Y, Huang G, Peng W, Shen H, Lei J, Yan N. Structure of the Na1.4-β1 Complex from Electric Eel. Cell. 2017;170(3):470–482.e11. PMID: 28735751

Qi S, Pang Y, Hu Q, Liu Q, Li H, Zhou Y, He T, Liang Q, Liu Y, Yuan X, Luo G, Li H, Wang J, Yan N, Shi Y. Crystal structure of the Caenorhabditis elegans apoptosome reveals an octameric assembly of CED-4. Cell. 2010;141(3):446–57. PMID: 20434985

Hao Q, Yin P, Li W, Wang L, Yan C, Lin Z, Wu J, Wang J, Yan F, Yan N. The molecular basis of ABA-independent inhibition of PP2Cs by a subclass of PYL proteins. Mol Cell. 2011;42(5):662–72. PMID: 21658606

Xie T, Ren R, Zhang Y- yuan, Pang Y, Yan C, Gong X, He Y, Li W, Miao D, Hao Q, Deng H, Wang Z, Wu J-W, Yan N. Molecular mechanism for inhibition of a critical component in the Arabidopsis thaliana abscisic acid signal transduction pathways, SnRK2.6, by protein phosphatase ABI1. J Biol Chem. 2012;287(1):794–802. PMCID: PMC3249133

Deng D, Yan C, Pan X, Mahfouz M, Wang J, Zhu J-K, Shi Y, Yan N. Structural basis for sequence-specific recognition of DNA by TAL effectors. Science. 2012;335(6069):720–3. PMCID: PMC3586824

Zhang X, Ren W, DeCaen P, Yan C, Tao X, Tang L, Wang J, Hasegawa K, Kumasaka T, He J, Wang J, Clapham D, Yan N. Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel. Nature. 2012;486(7401):130–4. PMCID: PMC3979295

Xia M, Liu H, Li Y, Yan N, Gong H. The mechanism of Na⁺/K⁺ selectivity in mammalian voltage-gated sodium channels based on molecular dynamics simulation. Biophys J. 2013;104(11):2401–9. PMCID: PMC3672897

Li W, Wang L, Sheng X, Yan C, Zhou R, Hang J, Yin P, Yan N. Molecular basis for the selective and ABA-independent inhibition of PP2CA by PYL13. Cell Res. 2013;23(12):1369–79. PMCID: PMC3847573

Deng D, Yan C, Wu J, Pan X, Yan N. Revisiting the TALE repeat. Protein Cell. 2014;5(4):297–306. PMCID: PMC3978159

Li Q, Yan C, Xu H, Wang Z, Long J, Li W, Wu J, Yin P, Yan N. Examination of the dimerization states of the single-stranded RNA recognition protein pentatricopeptide repeat 10 (PPR10). J Biol Chem. 2014;289(45):31503–12. PMCID: PMC4223348

Wu J, Yan Z, Li Z, Yan C, Lu S, Dong M, Yan N. Structure of the voltage-gated calcium channel Cav1.1 complex. Science. 2015;350(6267):aad2395. PMID: 26680202

Qian H, Zhao X, Cao P, Lei J, Yan N, Gong X. Structure of the Human Lipid Exporter ABCA1. Cell. 2017;169(7):1228–1239.e10. PMID: 28602350

Tamayo J, Teramoto T, Chatterjee S, Hall T, Gavis E. The Drosophila hnRNP F/H Homolog Glorund Uses Two Distinct RNA-Binding Modes to Diversify Target Recognition. Cell Rep. 2017;19(1):150–161. PMCID: PMC5392723