Department of Molecular Biology

Off screen link: Skip to content Off screen link: Skip to search
Princeton University
Home

Main Menu

  • Department
    Department
    • Chair’s Welcome
    • Administration & Staff
    • Associated Programs, Institutes & Departments
    • Grants Submission Policy & Funding Opportunities
    • Open Positions
    • MolBio Annual Retreat
      • MolBio Retreat Archive
        • 2024 MolBio Retreat Schedule
        • MolBio Retreat 2023 Schedule
  • Faculty & Research
    Faculty & Research
    • Faculty
    • Research Areas
      • Biochemistry, Biophysics & Structural Biology
      • Cell Biology, Development & Cancer
      • Genetics & Genomics
      • Microbiology, Virology & Immunology
      • Quantitative & Computational Biology
  • Postdoc
    Postdoc
    • Overview
    • Prospective Postdoc
    • New Postdoc
    • Postdoc Community
    • Career Development
    • Lewis-Sigler Fellows
    • Contacts
  • Graduate
    Graduate
    • Overview
    • Admission & Financial Support
    • Requirements
    • Courses
    • MD/PhD Program
    • MolBio Scholars
    • Outreach Program
    • Faculty Graduate Committee
    • Department Life
      • Life in the Department
      • Graduate Student Committees
      • Career Resources
      • Student Life
      • Incoming Graduate Students
    • Molecular Biology Training Grants
  • Undergraduate
    Undergraduate
    • Overview
    • Teaching Mission
    • Major
      • Major Requirements
      • Departmentals
      • Declare a Major
      • Typical Paths
      • Courses
      • Minor & Certificate Programs
      • Study Abroad
      • Junior Independent Work
      • Senior Thesis
    • Research
      • Current Lab Assignments
      • Summer Research
      • Sophomore Research Course
      • Internship Milestone Credit
      • Undergraduate Publications
    • Career Resources
    • Community
      • Undergraduate Community
      • Important Dates and Deadlines
      • Class Day
    • Contacts
  • Core Facilities
    Core Facilities
    • Overview
    • Shared Imaging Facilities
      • Confocal Microscopy
        • Instruments
        • Fluorescent Dyes
        • ILab Calendar and Service Requests
        • User Training
        • Nikon Center of Excellence
        • Contact
      • Electron Microscopy
        • Equipment
        • Pricing
        • Contacts
      • Imaging & Analysis Center
      • Nikon Center of Excellence
    • Shared Research Facilities
      • Biophysics
      • Drosophila Media
      • Flow Cytometry
        • Facility Use
        • Instruments
        • ILab Calendar and Service Requests
        • Contact
      • Genome Editing Shared Resource (Rutgers-CINJ)
      • Histology
      • Lab Animal Resources
      • Macromolecular Crystallography
      • NMR Facility
      • Proteomics & Mass Spec
        • Proteomics & MS Services
        • Protocols & Guidelines
      • Research Computing
      • Sequencing & Microarray
      • Synseq
    • Other Facilities
      • IT Support
      • Facilities & Maintenance
      • Environmental Health & Safety (EHS)
  • Community
    Community
    • Community & Connection Committee
    • Code of Conduct
  • Apply & Visit
  • Contact
  • People
  • Donors
  • News
  • Events
    • Events Archive

Search

Amino Acid Sequence

  • 1.
    Clark K, Covington B, Seyedsayamdost M. Biosynthesis-guided discovery reveals enteropeptins as alternative sactipeptides containing N-methylornithine. Nat Chem. 2022;14(12):1390–1398. PMID: 36316408
    Reference Link
  • 1.
    Elashal H, Koos J, Cheung-Lee W, Choi B, Cao L, Richardson M, White H, Link J. Biosynthesis and characterization of fuscimiditide, an aspartimidylated graspetide. Nat Chem. 2022;14(11):1325–1334. PMCID: PMC10078976
    Reference Link
  • 1.
    Behnke M, Khan A, Lauron E, Jimah J, Wang Q, Tolia N, Sibley D. Rhoptry Proteins ROP5 and ROP18 Are Major Murine Virulence Factors in Genetically Divergent South American Strains of Toxoplasma gondii. PLoS Genet. 2015;11(8):e1005434. PMCID: PMC4546408
    Reference Link
  • 1.
    Zhang R, Lee D, Jimah J, Gerassimov N, Yang C, Kim S, Luvsanjav D, Winkelman J, Mettlen M, Abrams M, Kalia R, Keene P, Pandey P, Ravaux B, Kim J, Ditlev J, Zhang G, Rosen M, Frost A, Alto N, Gardel M, Schmid S, Svitkina T, Hinshaw J, Chen E. Dynamin regulates the dynamics and mechanical strength of the actin cytoskeleton as a multifilament actin-bundling protein. Nat Cell Biol. 2020;22(6):674–688. PMCID: PMC7953826
    Reference Link
  • 1.
    Caruso A, Seyedsayamdost M. Radical SAM Enzyme QmpB Installs Two 9-Membered Ring Sactionine Macrocycles during Biogenesis of a Ribosomal Peptide Natural Product. J Org Chem. 2021;86(16):11284–11289. PMID: 34351169
    Reference Link
  • 1.
    Schröder H, Zhang Y, Link J. Dynamic covalent self-assembly of mechanically interlocked molecules solely made from peptides. Nat Chem. 2021;13(9):850–857. PMCID: PMC8446321
    Reference Link
  • 1.
    Huang J, Yuan Y, Zhao N, Pu D, Tang Q, Zhang S, Luo S, Yang X, Wang N, Xiao Y, Zhang T, Liu Z, Sakata-Kato T, Jiang X, Kato N, Yan N, Yin H. Orthosteric-allosteric dual inhibitors of PfHT1 as selective antimalarial agents. Proc Natl Acad Sci U S A. 2021;118(3). PMCID: PMC7826358
    Reference Link
  • 1.
    Jiang X, Yuan Y, Huang J, Zhang S, Luo S, Wang N, Pu D, Zhao N, Tang Q, Hirata K, Yang X, Jiao Y, Sakata-Kato T, Wu J-W, Yan C, Kato N, Yin H, Yan N. Structural Basis for Blocking Sugar Uptake into the Malaria Parasite Plasmodium falciparum. Cell. 2020;183(1):258–268.e12. PMID: 32860739
    Reference Link
  • 1.
    Qian H, Wu X, Du X, Yao X, Zhao X, Lee J, Yang H, Yan N. Structural Basis of Low-pH-Dependent Lysosomal Cholesterol Egress by NPC1 and NPC2. Cell. 2020;182(1):98–111.e18. PMID: 32544384
    Reference Link
  • 1.
    Caruso A, Bushin L, Clark K, Martinie R, Seyedsayamdost M. Radical Approach to Enzymatic β-Thioether Bond Formation. J Am Chem Soc. 2019;141(2):990–997. PMID: 30521328
    Reference Link
  • 1.
    Cheung-Lee W, Cao L, Link J. Pandonodin: A Proteobacterial Lasso Peptide with an Exceptionally Long C-Terminal Tail. ACS Chem Biol. 2019;14(12):2783–2792. PMCID: PMC7010350
    Reference Link
  • 1.
    Zhao Y, Huang G, Wu J, Wu Q, Gao S, Yan Z, Lei J, Yan N. Molecular Basis for Ligand Modulation of a Mammalian Voltage-Gated Ca Channel. Cell. 2019;177(6):1495–1506.e12. PMID: 31150622
    Reference Link
  • 1.
    Zhang C, Seyedsayamdost M. CanE, an Iron/2-Oxoglutarate-Dependent Lasso Peptide Hydroxylase from . ACS Chem Biol. 2020;15(4):890–894. PMID: 32191027
    Reference Link
  • 1.
    Seo K, Kleiner R. YTHDF2 Recognition of N-Methyladenosine (mA)-Modified RNA Is Associated with Transcript Destabilization. ACS Chem Biol. 2020;15(1):132–139. PMCID: PMC7025767
    Reference Link
  • 1.
    Valencia A, Collings C, Dao H, St Pierre R, Cheng Y-C, Huang J, Sun Z-Y, Seo H-S, Mashtalir N, Comstock D, Bolonduro O, Vangos N, Yeoh Z, Dornon M, Hermawan C, Barrett L, Dhe-Paganon S, Woolf C, Muir T, Kadoch C. Recurrent SMARCB1 Mutations Reveal a Nucleosome Acidic Patch Interaction Site That Potentiates mSWI/SNF Complex Chromatin Remodeling. Cell. 2019;179(6):1342–1356.e23. PMCID: PMC7175411
    Reference Link
  • 1.
    Zhao Y, Huang G, Wu Q, Wu K, Li R, Lei J, Pan X, Yan N. Cryo-EM structures of apo and antagonist-bound human Ca3.1. Nature. 2019;576(7787):492–497. PMCID: 18083096
    Reference Link
  • 1.
    Bushin L, Clark K, Pelczer I, Seyedsayamdost M. Charting an Unexplored Streptococcal Biosynthetic Landscape Reveals a Unique Peptide Cyclization Motif. J Am Chem Soc. 2018;140(50):17674–17684. PMID: 30398325
    Reference Link
  • 1.
    Caruso A, Martinie R, Bushin L, Seyedsayamdost M. Macrocyclization via an Arginine-Tyrosine Crosslink Broadens the Reaction Scope of Radical -Adenosylmethionine Enzymes. J Am Chem Soc. 2019;141(42):16610–16614. PMID: 31596076
    Reference Link
  • 1.
    Stevens A, Sekar G, Gramespacher J, Cowburn D, Muir T. An Atypical Mechanism of Split Intein Molecular Recognition and Folding. J Am Chem Soc. 2018;140(37):11791–11799. PMCID: PMC7232844
    Reference Link
  • 1.
    Clark K, Bushin L, Seyedsayamdost M. Aliphatic Ether Bond Formation Expands the Scope of Radical SAM Enzymes in Natural Product Biosynthesis. J Am Chem Soc. 2019;141(27):10610–10615. PMID: 31246011
    Reference Link
  • 1.
    Wang S-W, Bitbol A-F, Wingreen N. Revealing evolutionary constraints on proteins through sequence analysis. PLoS Comput Biol. 2019;15(4):e1007010. PMCID: PMC6502352
    Reference Link
  • 1.
    Jiao J, He M, Port S, Baker R, Xu Y, Qu H, Xiong Y, Wang Y, Jin H, Eisemann T, Hughson F, Zhang Y. Munc18-1 catalyzes neuronal SNARE assembly by templating SNARE association. Elife. 2018;7. PMCID: PMC6320071
    Reference Link
  • 1.
    Carabetta V, Greco T, Cristea I, Dubnau D. YfmK is an N-lysine acetyltransferase that directly acetylates the histone-like protein HBsu in . Proc Natl Acad Sci U S A. 2019;116(9):3752–3757. PMCID: PMC6397556
    Reference Link
  • 1.
    Shen H, Liu D, Wu K, Lei J, Yan N. Structures of human Na1.7 channel in complex with auxiliary subunits and animal toxins. Science. 2019;363(6433):1303–1308. PMID: 30765606
    Reference Link
  • 1.
    Pan X, Li Z, Huang X, Huang G, Gao S, Shen H, Liu L, Lei J, Yan N. Molecular basis for pore blockade of human Na channel Na1.2 by the μ-conotoxin KIIIA. Science. 2019;363(6433):1309–1313. PMID: 30765605
    Reference Link
  • 1.
    Pan X, Li Z, Zhou Q, Shen H, Wu K, Huang X, Chen J, Zhang J, Zhu X, Lei J, Xiong W, Gong H, Xiao B, Yan N. Structure of the human voltage-gated sodium channel Na1.4 in complex with β1. Science. 2018;362(6412). PMID: 30190309
    Reference Link
  • 1.
    Shen H, Li Z, Jiang Y, Pan X, Wu J, Cristofori-Armstrong B, Smith J, K Y Chin Y, Lei J, Zhou Q, King G, Yan N. Structural basis for the modulation of voltage-gated sodium channels by animal toxins. Science. 2018;362(6412). PMID: 30049784
    Reference Link
  • 1.
    Piscotta F, Jeffrey P, Link J. ParST is a widespread toxin-antitoxin module that targets nucleotide metabolism. Proc Natl Acad Sci U S A. 2019;116(3):826–834. PMCID: PMC6338849
    Reference Link
  • 1.
    Ciccia A, Nimonkar A, Hu Y, Hajdu I, Achar Y, Izhar L, Petit S, Adamson B, Yoon J, Kowalczykowski S, Livingston D, Haracska L, Elledge S. Polyubiquitinated PCNA recruits the ZRANB3 translocase to maintain genomic integrity after replication stress. Mol Cell. 2012;47(3):396–409. PMCID: PMC3613862
    Reference Link
  • 1.
    Munro D, Ghersi D, Singh M. Two critical positions in zinc finger domains are heavily mutated in three human cancer types. PLoS Comput Biol. 2018;14(6):e1006290. PMCID: PMC6040777
    Reference Link
  • 1.
    Wojcik F, Dann G, Beh L, Debelouchina G, Hofmann R, Muir T. Functional crosstalk between histone H2B ubiquitylation and H2A modifications and variants. Nat Commun. 2018;9(1):1394. PMCID: PMC5895630
    Reference Link
  • 1.
    Schramma K, Seyedsayamdost M. Lysine-Tryptophan-Crosslinked Peptides Produced by Radical SAM Enzymes in Pathogenic Streptococci. ACS Chem Biol. 2017;12(4):922–927. PMID: 28191919
    Reference Link
  • 1.
    Schramma K, Forneris C, Caruso A, Seyedsayamdost M. Mechanistic Investigations of Lysine-Tryptophan Cross-Link Formation Catalyzed by Streptococcal Radical S-Adenosylmethionine Enzymes. Biochemistry. 2018;57(4):461–468. PMID: 29320164
    Reference Link
  • 1.
    Bradley L, Kleiner R, Wang A, Hecht M, Wood D. An intein-based genetic selection allows the construction of a high-quality library of binary patterned de novo protein sequences. Protein Eng Des Sel. 2005;18(4):201–7. PMID: 15849217
    Reference Link
  • 1.
    Zong C, Cheung-Lee W, Elashal H, Raj M, Link J. Albusnodin: an acetylated lasso peptide from Streptomyces albus. Chem Commun (Camb). 2018;54(11):1339–1342. PMCID: PMC5835390
    Reference Link
  • 1.
    Hecht M, Zarzhitsky S, Karas C, Chari S. Are natural proteins special? Can we do that?. Curr Opin Struct Biol. 2018;48:124–132. PMID: 29306103
    Reference Link
  • 1.
    Gramespacher J, Stevens A, Thompson R, Muir T. Improved protein splicing using embedded split inteins. Protein Sci. 2018;27(3):614–619. PMCID: PMC5818749
    Reference Link
  • 1.
    Yan Z, Zhou Q, Wang L, Wu J, Zhao Y, Huang G, Peng W, Shen H, Lei J, Yan N. Structure of the Na1.4-β1 Complex from Electric Eel. Cell. 2017;170(3):470–482.e11. PMID: 28735751
    Reference Link
  • 1.
    Qi S, Pang Y, Hu Q, Liu Q, Li H, Zhou Y, He T, Liang Q, Liu Y, Yuan X, Luo G, Li H, Wang J, Yan N, Shi Y. Crystal structure of the Caenorhabditis elegans apoptosome reveals an octameric assembly of CED-4. Cell. 2010;141(3):446–57. PMID: 20434985
    Reference Link
  • 1.
    Hao Q, Yin P, Li W, Wang L, Yan C, Lin Z, Wu J, Wang J, Yan F, Yan N. The molecular basis of ABA-independent inhibition of PP2Cs by a subclass of PYL proteins. Mol Cell. 2011;42(5):662–72. PMID: 21658606
    Reference Link
  • 1.
    Xie T, Ren R, Zhang Y- yuan, Pang Y, Yan C, Gong X, He Y, Li W, Miao D, Hao Q, Deng H, Wang Z, Wu J-W, Yan N. Molecular mechanism for inhibition of a critical component in the Arabidopsis thaliana abscisic acid signal transduction pathways, SnRK2.6, by protein phosphatase ABI1. J Biol Chem. 2012;287(1):794–802. PMCID: PMC3249133
    Reference Link
  • 1.
    Deng D, Yan C, Pan X, Mahfouz M, Wang J, Zhu J-K, Shi Y, Yan N. Structural basis for sequence-specific recognition of DNA by TAL effectors. Science. 2012;335(6069):720–3. PMCID: PMC3586824
    Reference Link
  • 1.
    Zhang X, Ren W, DeCaen P, Yan C, Tao X, Tang L, Wang J, Hasegawa K, Kumasaka T, He J, Wang J, Clapham D, Yan N. Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel. Nature. 2012;486(7401):130–4. PMCID: PMC3979295
    Reference Link
  • 1.
    Xia M, Liu H, Li Y, Yan N, Gong H. The mechanism of Na⁺/K⁺ selectivity in mammalian voltage-gated sodium channels based on molecular dynamics simulation. Biophys J. 2013;104(11):2401–9. PMCID: PMC3672897
    Reference Link
  • 1.
    Li W, Wang L, Sheng X, Yan C, Zhou R, Hang J, Yin P, Yan N. Molecular basis for the selective and ABA-independent inhibition of PP2CA by PYL13. Cell Res. 2013;23(12):1369–79. PMCID: PMC3847573
    Reference Link
  • 1.
    Deng D, Yan C, Wu J, Pan X, Yan N. Revisiting the TALE repeat. Protein Cell. 2014;5(4):297–306. PMCID: PMC3978159
    Reference Link
  • 1.
    Li Q, Yan C, Xu H, Wang Z, Long J, Li W, Wu J, Yin P, Yan N. Examination of the dimerization states of the single-stranded RNA recognition protein pentatricopeptide repeat 10 (PPR10). J Biol Chem. 2014;289(45):31503–12. PMCID: PMC4223348
    Reference Link
  • 1.
    Wu J, Yan Z, Li Z, Yan C, Lu S, Dong M, Yan N. Structure of the voltage-gated calcium channel Cav1.1 complex. Science. 2015;350(6267):aad2395. PMID: 26680202
    Reference Link
  • 1.
    Qian H, Zhao X, Cao P, Lei J, Yan N, Gong X. Structure of the Human Lipid Exporter ABCA1. Cell. 2017;169(7):1228–1239.e10. PMID: 28602350
    Reference Link
  • 1.
    Tamayo J, Teramoto T, Chatterjee S, Hall T, Gavis E. The Drosophila hnRNP F/H Homolog Glorund Uses Two Distinct RNA-Binding Modes to Diversify Target Recognition. Cell Rep. 2017;19(1):150–161. PMCID: PMC5392723
    Reference Link

Pagination

  • Page 1
  • Next page ››

Footer

Connect with Mol Bio

  • Facebook
  • Twitter

Department of Molecular Biology
119 Lewis Thomas Laboratory
Washington Road
Princeton, NJ 08544-1014
Need help? Contact us

Visitor Parking Information

Intranet Login

Privacy Notice

Explore

  • Graduate Program
  • Undergraduate Program
  • Summer Undergraduate Research Program (SURP)
  • Research Areas
  • Molecular Biology Faculty
  • Faculty Research Labs

Core Facilities & Instruments

  • Biophysics
  • Confocal Microscopy
  • Drosophila Media
  • Electron Microscopy
  • Flow Cytometry
  • Histology
  • Imaging Facility at LSI
  • Laboratory Animal Resources
  • Macromolecular Crystallography
  • Nikon Center of Excellence
  • Proteomics & Mass Spectrometry
  • Sequencing & Microarray
  • Synseq

Programs & Institutes

  • Graduate Program in Quantitative and Computational Biology
  • Glenn Laboratories For Aging Research
  • Lewis-Sigler Institute for Integrative Genomics
  • Princeton Neuroscience Institute
  • Diversity & Non-Discrimination
  • Accessibility Help

© 2025 The Trustees of Princeton University

Princeton University