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Aging

  • 1.
    Mesa K, O’Connor K, Ng C, Salvatore S, Littman D. Niche-specific macrophage loss promotes skin capillary aging. bioRxiv : the preprint server for biology. 2023;. PMCID: PMC10473701
    Reference Link
  • 1.
    Overman K, Choi D, Leung K, Shaevitz J, Berman G. Measuring the repertoire of age-related behavioral changes in Drosophila melanogaster. PLoS Comput Biol. 2022;18(2):e1009867. PMCID: PMC8903287
    Reference Link
  • 1.
    McReynolds M, Chellappa K, Chiles E, Jankowski C, Shen Y, Chen L, Descamps H, Mukherjee S, Bhat Y, Lingala S, Chu Q, Botolin P, Hayat F, Doke T, Susztak K, Thaiss C, Lu W, Migaud M, Su X, Rabinowitz J, Baur J. NAD flux is maintained in aged mice despite lower tissue concentrations. Cell Syst. 2021;12(12):1160–1172.e4. PMCID: PMC8678178
    Reference Link
  • 1.
    Parkhitko A, Wang L, Filine E, Jouandin P, Leshchiner D, Binari R, Asara J, Rabinowitz J, Perrimon N. A genetic model of methionine restriction extends health- and lifespan. Proc Natl Acad Sci U S A. 2021;118(40). PMCID: PMC8501845
    Reference Link
  • 1.
    Joyce B, Gao T, Koss K, Zheng Y, Cardenas A, Heiss J, Just A, Zhang K, van Horn L, Allen N, Greenland P, Cohen S, Gordon-Larsen P, Mitchell C, McLanahan S, Schneper L, Notterman D, Rifas-Shiman S, Oken E, Hivert M-F, Wright R, Baccarelli A, Lloyd-Jones D, Hou L. Impact of paternal education on epigenetic ageing in adolescence and mid-adulthood: a multi-cohort study in the USA and Mexico. Int J Epidemiol. 2022;51(3):870–884. PMCID: PMC9189973
    Reference Link
  • 1.
    Notterman D. Growing Old Before Their Time: Measuring Aging. Pediatrics. 2021;147(6). PMCID: PMC8168600
    Reference Link
  • 1.
    Lee Y, Jung Y, Jeong D-E, Hwang W, Ham S, Park H-E, Kwon S, Ashraf J, Murphy C, Lee S-J. Reduced insulin/IGF1 signaling prevents immune aging via ZIP-10/bZIP-mediated feedforward loop. J Cell Biol. 2021;220(5). PMCID: PMC7941181
    Reference Link
  • 1.
    Minhas P, Latif-Hernandez A, McReynolds M, Durairaj A, Wang Q, Rubin A, Joshi A, He J, Gauba E, Liu L, Wang C, Linde M, Sugiura Y, Moon P, Majeti R, Suematsu M, Mochly-Rosen D, Weissman I, Longo F, Rabinowitz J, Andreasson K. Restoring metabolism of myeloid cells reverses cognitive decline in ageing. Nature. 2021;590(7844):122–128. PMCID: PMC8274816
    Reference Link
  • 1.
    Parkhitko A, Ramesh D, Wang L, Leshchiner D, Filine E, Binari R, Olsen A, Asara J, Cracan V, Rabinowitz J, Brockmann A, Perrimon N. Downregulation of the tyrosine degradation pathway extends lifespan. Elife. 2020;9. PMCID: PMC7744100
    Reference Link
  • 1.
    Chini C, Peclat T, Warner G, Kashyap S, Espindola-Netto J, de Oliveira G, Gomez L, Hogan K, Tarragó M, Puranik A, Agorrody G, Thompson K, Dang K, Clarke S, Childs B, Kanamori K, Witte M, Vidal P, Kirkland A, De Cecco M, Chellappa K, McReynolds M, Jankowski C, Tchkonia T, Kirkland J, Sedivy J, van Deursen J, Baker D, van Schooten W, Rabinowitz J, Baur J, Chini E. CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD and NMN levels. Nat Metab. 2020;2(11):1284–1304. PMCID: PMC8752031
    Reference Link
  • 1.
    Lafontaine D, Riback J, Bascetin R, Brangwynne C. The nucleolus as a multiphase liquid condensate. Nat Rev Mol Cell Biol. 2021;22(3):165–182. PMCID: 147800
    Reference Link
  • 1.
    Templeman N, Cota V, Keyes W, Kaletsky R, Murphy C. CREB Non-autonomously Controls Reproductive Aging through Hedgehog/Patched Signaling. Dev Cell. 2020;54(1):92–105.e5. PMCID: PMC7837322
    Reference Link
  • 1.
    Roussarie J-P, Yao V, Rodriguez-Rodriguez P, Oughtred R, Rust J, Plautz Z, Kasturia S, Albornoz C, Wang W, Schmidt E, Dannenfelser R, Tadych A, Brichta L, Barnea-Cramer A, Heintz N, Hof P, Heiman M, Dolinski K, Flajolet M, Troyanskaya O, Greengard P. Selective Neuronal Vulnerability in Alzheimer’s Disease: A Network-Based Analysis. Neuron. 2020;107(5):821–835.e12. PMCID: PMC7580783
    Reference Link
  • 1.
    Notterman D, Schneper L. Telomere Time-Why We Should Treat Biological Age Cautiously. JAMA Netw Open. 2020;3(5):e204352. PMID: 32364591
    Reference Link
  • 1.
    Betsinger C, Cristea I. Mitochondrial Function, Metabolic Regulation, and Human Disease Viewed through the Prism of Sirtuin 4 (SIRT4) Functions. J Proteome Res. 2019;18(5):1929–1938. PMCID: PMC6889813
    Reference Link
  • 1.
    Kaletsky R, Murphy C. Transcriptional Profiling of C. elegans Adult Cells and Tissues with Age. Methods Mol Biol. 2020;2144:177–186. PMID: 32410035
    Reference Link
  • 1.
    Minhas P, Liu L, Moon P, Joshi A, Dove C, Mhatre S, Contrepois K, Wang Q, Lee B, Coronado M, Bernstein D, Snyder M, Migaud M, Majeti R, Mochly-Rosen D, Rabinowitz J, Andreasson K. Macrophage de novo NAD synthesis specifies immune function in aging and inflammation. Nat Immunol. 2019;20(1):50–63. PMCID: PMC6768398
    Reference Link
  • 1.
    Templeman N, Luo S, Kaletsky R, Shi C, Ashraf J, Keyes W, Murphy C. Insulin Signaling Regulates Oocyte Quality Maintenance with Age via Cathepsin B Activity. Curr Biol. 2018;28(5):753–760.e4. PMCID: PMC5893159
    Reference Link
  • 1.
    Fernández-Capetillo Óscar, Yan N, Dionne J, Bassett D, Sebastian S, Hendon C, Schlichting H, Baker M. Hopes for the year ahead. Nature. 2015;517(7532):111–3. PMID: 25568916
    Reference Link
  • 1.
    Mirzaei M, Gupta V, Chick J, Greco T, Wu Y, Chitranshi N, Wall R, Hone E, Deng L, Dheer Y, Abbasi M, Rezaeian M, Braidy N, You Y, Salekdeh G, Haynes P, Molloy M, Martins R, Cristea I, Gygi S, Graham S, Gupta V. Age-related neurodegenerative disease associated pathways identified in retinal and vitreous proteome from human glaucoma eyes. Sci Rep. 2017;7(1):12685. PMCID: PMC5627288
    Reference Link
  • 1.
    Templeman N, Murphy C. Regulation of reproduction and longevity by nutrient-sensing pathways. J Cell Biol. 2018;217(1):93–106. PMCID: PMC5748989
    Reference Link
  • 1.
    Charruau P, Johnston R, Stahler D, Lea A, Snyder-Mackler N, Smith D, vonHoldt B, Cole S, Tung J, Wayne R. Pervasive Effects of Aging on Gene Expression in Wild Wolves. Mol Biol Evol. 2016;33(8):1967–78. PMCID: PMC5854094
    Reference Link
  • 1.
    Frederick D, Loro E, Liu L, Davila A, Chellappa K, Silverman I, Quinn W, Gosai S, Tichy E, Davis J, Mourkioti F, Gregory B, Dellinger R, Redpath P, Migaud M, Nakamaru-Ogiso E, Rabinowitz J, Khurana T, Baur J. Loss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle. Cell Metab. 2016;24(2):269–82. PMCID: PMC4985182
    Reference Link
  • 1.
    Snir S, vonHoldt B, Pellegrini M. A Statistical Framework to Identify Deviation from Time Linearity in Epigenetic Aging. PLoS Comput Biol. 2016;12(11):e1005183. PMCID: PMC5106012
    Reference Link
  • 1.
    DiLoreto R, Murphy C. The cell biology of aging. Mol Biol Cell. 2015;26(25):4524–31. PMCID: PMC4678010
    Reference Link
  • 1.
    Tetruashvily M, McDonald M, Frietze K, Boulanger L. MHCI promotes developmental synapse elimination and aging-related synapse loss at the vertebrate neuromuscular junction. Brain Behav Immun. 2016;56:197–208. PMCID: PMC5813483
    Reference Link
  • 1.
    Kaletsky R, Lakhina V, Arey R, Williams A, Landis J, Ashraf J, Murphy C. The C. elegans adult neuronal IIS/FOXO transcriptome reveals adult phenotype regulators. Nature. 2016;529(7584):92–6. PMCID: PMC4708089
    Reference Link
  • 1.
    Li L-B, Lei H, Arey R, Li P, Liu J, Murphy C, Xu X, Shen K. The Neuronal Kinesin UNC-104/KIF1A Is a Key Regulator of Synaptic Aging and Insulin Signaling-Regulated Memory. Curr Biol. 2016;26(5):605–15. PMCID: PMC4783184
    Reference Link
  • 1.
    McKoy A, Chen J, Schüpbach T, Hecht M. Structure-activity relationships for a series of compounds that inhibit aggregation of the Alzheimer’s peptide, Aβ42. Chem Biol Drug Des. 2014;84(5):505–12. PMCID: PMC4197064
    Reference Link
  • 1.
    Peshkin L, Wühr M, Pearl E, Haas W, Freeman R, Gerhart J, Klein A, Horb M, Gygi S, Kirschner M. On the Relationship of Protein and mRNA Dynamics in Vertebrate Embryonic Development. Dev Cell. 2015;35(3):383–94. PMCID: PMC4776761
    Reference Link

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