Title | The Jekyll-and-Hyde chemistry of Phaeobacter gallaeciensis. |
Publication Type | Journal Article |
Year of Publication | 2011 |
Authors | Seyedsayamdost, MR, Case, RJ, Kolter, R, Clardy, J |
Journal | Nat Chem |
Volume | 3 |
Issue | 4 |
Pagination | 331-5 |
Date Published | 2011 Apr |
ISSN | 1755-4349 |
Keywords | Bacteria, Bacterial Toxins, Biosynthetic Pathways, Cell Proliferation, Coumaric Acids, Crystallography, X-Ray, Haptophyta, Inhibitory Concentration 50, Magnetic Resonance Spectroscopy, Mass Spectrometry, Microalgae, Models, Biological, Molecular Conformation, Molecular Structure, Propionates, Roseobacter, Spectrophotometry, Ultraviolet, Symbiosis |
Abstract | <p>Emiliania huxleyi, an environmentally important marine microalga, has a bloom-and-bust lifestyle in which massive algal blooms appear and fade. Phaeobacter gallaeciensis belongs to the roseobacter clade of α-Proteobacteria, the populations of which wax and wane with that of E. huxleyi. Roseobacter are thought to promote algal growth by biosynthesizing and secreting antibiotics and growth stimulants (auxins). Here we show that P. gallaeciensis switches its secreted small molecule metabolism to the production of potent and selective algaecides, the roseobacticides, in response to p-coumaric acid, an algal lignin breakdown product that is symptomatic of aging algae. This switch converts P. gallaeciensis into an opportunistic pathogen of its algal host.</p> |
DOI | 10.1038/nchem.1002 |
Alternate Journal | Nat Chem |
PubMed ID | 21430694 |
PubMed Central ID | PMC3376411 |
Grant List | R01 GM082137 / GM / NIGMS NIH HHS / United States K99 GM098299 / GM / NIGMS NIH HHS / United States R01 GM086258 / GM / NIGMS NIH HHS / United States GM82137 / GM / NIGMS NIH HHS / United States R01 CA024487 / CA / NCI NIH HHS / United States GM58213 / GM / NIGMS NIH HHS / United States CA24487 / CA / NCI NIH HHS / United States R00 GM098299 / GM / NIGMS NIH HHS / United States R01 GM058213 / GM / NIGMS NIH HHS / United States GM086258 / GM / NIGMS NIH HHS / United States |