Title | Intrinsic and Innate Defenses of Neurons: Détente with the Herpesviruses. |
Publication Type | Journal Article |
Year of Publication | 2017 |
Authors | Enquist, LW, Leib, DA |
Journal | J Virol |
Volume | 91 |
Issue | 1 |
Date Published | 2017 Jan 01 |
ISSN | 1098-5514 |
Keywords | Autophagy, Axonal Transport, Co-Repressor Proteins, Gene Silencing, Herpesviridae, Histone Deacetylases, Histone Demethylases, Humans, Immediate-Early Proteins, Immune Evasion, Immunity, Innate, Interferons, MicroRNAs, Nerve Tissue Proteins, Neurons, Signal Transduction, Ubiquitin-Protein Ligases, Virus Latency |
Abstract | <p>Neuroinvasive herpesviruses have evolved to efficiently infect and establish latency in neurons. The nervous system has limited capability to regenerate, so immune responses therein are carefully regulated to be nondestructive, with dependence on atypical intrinsic and innate defenses. In this article we review studies of some of these noncanonical defense pathways and how herpesvirus gene products counter them, highlighting the contributions that primary neuronal in vitro models have made to our understanding of this field.</p> |
DOI | 10.1128/JVI.01200-16 |
Alternate Journal | J Virol |
PubMed ID | 27795407 |
PubMed Central ID | PMC5165195 |
Grant List | R01 NS033506 / NS / NINDS NIH HHS / United States R01 EY009083 / EY / NEI NIH HHS / United States P01 AI098681 / AI / NIAID NIH HHS / United States R01 NS060699 / NS / NINDS NIH HHS / United States R37 NS033506 / NS / NINDS NIH HHS / United States |