Intrinsic and Innate Defenses of Neurons: Détente with the Herpesviruses.
Publication Year
2017
Type
Journal Article
Abstract
Neuroinvasive herpesviruses have evolved to efficiently infect and establish latency in neurons. The nervous system has limited capability to regenerate, so immune responses therein are carefully regulated to be nondestructive, with dependence on atypical intrinsic and innate defenses. In this article we review studies of some of these noncanonical defense pathways and how herpesvirus gene products counter them, highlighting the contributions that primary neuronal in vitro models have made to our understanding of this field.
Keywords
Humans,
Signal Transduction,
MicroRNAs,
Neurons,
Nerve Tissue Proteins,
Ubiquitin-Protein Ligases,
Immunity, Innate,
Interferons,
Gene Silencing,
Immune Evasion,
Histone Deacetylases,
Herpesviridae,
Immediate-Early Proteins,
Virus Latency,
Co-Repressor Proteins,
Autophagy,
Axonal Transport,
Histone Demethylases
Journal
J Virol
Volume
91
Issue
1
Date Published
2017 Jan 01
ISSN Number
1098-5514
Alternate Journal
J Virol
PMCID
PMC5165195
PMID
27795407