| Title | Intricate Roles of Mammalian Sirtuins in Defense against Viral Pathogens. |
| Publication Type | Journal Article |
| Year of Publication | 2016 |
| Authors | Budayeva, HG, Rowland, EA, Cristea, IM |
| Journal | J Virol |
| Volume | 90 |
| Issue | 1 |
| Pagination | 5-8 |
| Date Published | 2016 Jan 01 |
| ISSN | 1098-5514 |
| Keywords | Animals, Host-Pathogen Interactions, Humans, Metabolic Networks and Pathways, Models, Biological, Sirtuins, Virus Diseases |
| Abstract | <p>For a number of years, sirtuin enzymes have been appreciated as effective "sensors" of the cellular environment to rapidly transmit information to diverse cellular pathways. Much effort was placed into exploring their roles in human cancers and aging. However, a growing body of literature brings these enzymes to the spotlight in the field of virology. Here, we discuss sirtuin functions in the context of viral infection, which provide regulatory points for therapeutic intervention against pathogens.</p> |
| DOI | 10.1128/JVI.03220-14 |
| Alternate Journal | J Virol |
| PubMed ID | 26491165 |
| PubMed Central ID | PMC4702534 |
| Grant List | R01 GM114141 / GM / NIGMS NIH HHS / United States AI102187 / AI / NIAID NIH HHS / United States GM114141 / GM / NIGMS NIH HHS / United States HL127640 / HL / NHLBI NIH HHS / United States |
