From intracellular signaling to population oscillations: bridging size- and time-scales in collective behavior.

TitleFrom intracellular signaling to population oscillations: bridging size- and time-scales in collective behavior.
Publication TypeJournal Article
Year of Publication2015
AuthorsSgro, AE, Schwab, DJ, Noorbakhsh, J, Mestler, T, Mehta, P, Gregor, T
JournalMol Syst Biol
Volume11
Issue1
Pagination779
Date Published2015 Jan 23
ISSN1744-4292
KeywordsDictyostelium, Gene Expression Regulation, Image Processing, Computer-Assisted, Microfluidic Analytical Techniques, Molecular Dynamics Simulation, Signal Transduction
Abstract

<p>Collective behavior in cellular populations is coordinated by biochemical signaling networks within individual cells. Connecting the dynamics of these intracellular networks to the population phenomena they control poses a considerable challenge because of network complexity and our limited knowledge of kinetic parameters. However, from physical systems, we know that behavioral changes in the individual constituents of a collectively behaving system occur in a limited number of well-defined classes, and these can be described using simple models. Here, we apply such an approach to the emergence of collective oscillations in cellular populations of the social amoeba Dictyostelium discoideum. Through direct tests of our model with quantitative in vivo measurements of single-cell and population signaling dynamics, we show how a simple model can effectively describe a complex molecular signaling network at multiple size and temporal scales. The model predicts novel noise-driven single-cell and population-level signaling phenomena that we then experimentally observe. Our results suggest that like physical systems, collective behavior in biology may be universal and described using simple mathematical models. </p>

DOI10.15252/msb.20145352
Alternate JournalMol. Syst. Biol.
PubMed ID25617347
PubMed Central IDPMC4332153
Grant ListK25 GM098875 / GM / NIGMS NIH HHS / United States
NIH K25 GM098875 / GM / NIGMS NIH HHS / United States
F32 GM103062 / GM / NIGMS NIH HHS / United States
P50 GM071508 / GM / NIGMS NIH HHS / United States
K25 GM086909 / GM / NIGMS NIH HHS / United States
R01 GM098407 / GM / NIGMS NIH HHS / United States
NIH K25 GM086909 / GM / NIGMS NIH HHS / United States