Interference with AI-2-mediated bacterial cell-cell communication.

TitleInterference with AI-2-mediated bacterial cell-cell communication.
Publication TypeJournal Article
Year of Publication2005
AuthorsXavier, KB, Bassler, BL
JournalNature
Volume437
Issue7059
Pagination750-3
Date Published2005 Sep 29
ISSN1476-4687
KeywordsBacteria, Biological Factors, Coculture Techniques, Escherichia coli, Escherichia coli Proteins, Homoserine, Lactones, Peptide Hydrolases, Repressor Proteins, Signal Transduction, Vibrio
Abstract

<p>Bacteria communicate by means of chemical signal molecules called autoinducers. This process, called quorum sensing, allows bacteria to count the members in the community and to alter gene expression synchronously across the population. Quorum-sensing-controlled processes are often crucial for successful bacterial--host relationships--both symbiotic and pathogenic. Most quorum-sensing autoinducers promote intraspecies communication, but one autoinducer, called AI-2, is produced and detected by a wide variety of bacteria and is proposed to allow interspecies communication. Here we show that some species of bacteria can manipulate AI-2 signalling and interfere with other species' ability to assess and respond correctly to changes in cell population density. AI-2 signalling, and the interference with it, could have important ramifications for eukaryotes in the maintenance of normal microflora and in protection from pathogenic bacteria.</p>

DOI10.1038/nature03960
Alternate JournalNature
PubMed ID16193054
PubMed Central IDPMC1388276
Grant ListR01 GM065859 / GM / NIGMS NIH HHS / United States