The influenza virus RNA polymerase as an innate immune agonist and antagonist.

TitleThe influenza virus RNA polymerase as an innate immune agonist and antagonist.
Publication TypeJournal Article
Year of Publication2021
AuthorsElshina, E, Velthuis, AJWTe
JournalCell Mol Life Sci
Volume78
Issue23
Pagination7237-7256
Date Published2021 Dec
ISSN1420-9071
Abstract

Influenza A viruses cause a mild-to-severe respiratory disease that affects millions of people each year. One of the many determinants of disease outcome is the innate immune response to the viral infection. While antiviral responses are essential for viral clearance, excessive innate immune activation promotes lung damage and disease. The influenza A virus RNA polymerase is one of viral proteins that affect innate immune activation during infection, but the mechanisms behind this activity are not well understood. In this review, we discuss how the viral RNA polymerase can both activate and suppress innate immune responses by either producing immunostimulatory RNA species or directly targeting the components of the innate immune signalling pathway, respectively. Furthermore, we provide a comprehensive overview of the polymerase residues, and their mutations, associated with changes in innate immune activation, and discuss their putative effects on polymerase function based on recent advances in our understanding of the influenza A virus RNA polymerase structure.

DOI10.1007/s00018-021-03957-w
Alternate JournalCell Mol Life Sci
PubMed ID34677644
PubMed Central IDPMC8532088
Grant List / WT_ / Wellcome Trust / United Kingdom
R21 AI147172 / AI / NIAID NIH HHS / United States
R21AI147172 / / National Institute of Allergy and Infectious Diseases /
206579/Z/17/Z / WT_ / Wellcome Trust / United Kingdom