Title | induces gut intraepithelial CD4CD8αα T cells. |
Publication Type | Journal Article |
Year of Publication | 2017 |
Authors | Cervantes-Barragan, L, Chai, JN, Tianero, MDiarey, Di Luccia, B, Ahern, PP, Merriman, J, Cortez, VS, Caparon, MG, Donia, MS, Gilfillan, S, Cella, M, Gordon, JI, Hsieh, C-S, Colonna, M |
Journal | Science |
Volume | 357 |
Issue | 6353 |
Pagination | 806-810 |
Date Published | 2017 Aug 25 |
ISSN | 1095-9203 |
Keywords | Animals, Basic Helix-Loop-Helix Transcription Factors, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Down-Regulation, Gastrointestinal Microbiome, Germ-Free Life, Indoles, Intestinal Mucosa, Intestine, Small, Limosilactobacillus reuteri, Mice, Mice, Inbred C57BL, Receptors, Aryl Hydrocarbon, Transcription Factors, Tryptophan |
Abstract | <p>The small intestine contains CD4CD8αα double-positive intraepithelial lymphocytes (DP IELs), which originate from intestinal CD4 T cells through down-regulation of the transcription factor Thpok and have regulatory functions. DP IELs are absent in germ-free mice, which suggests that their differentiation depends on microbial factors. We found that DP IEL numbers in mice varied in different vivaria, correlating with the presence of This species induced DP IELs in germ-free mice and conventionally-raised mice lacking these cells. did not shape the DP-IEL-TCR (TCR, T cell receptor) repertoire but generated indole derivatives of tryptophan that activated the aryl-hydrocarbon receptor in CD4 T cells, allowing Thpok down-regulation and differentiation into DP IELs. Thus, , together with a tryptophan-rich diet, can reprogram intraepithelial CD4 T cells into immunoregulatory T cells.</p> |
DOI | 10.1126/science.aah5825 |
Alternate Journal | Science |
PubMed ID | 28775213 |
PubMed Central ID | PMC5687812 |
Grant List | R01 DK103039 / DK / NIDDK NIH HHS / United States R01 CA176695 / CA / NCI NIH HHS / United States R01 DK030292 / DK / NIDDK NIH HHS / United States DP2 AI124441 / AI / NIAID NIH HHS / United States R01 AI070759 / AI / NIAID NIH HHS / United States R01 DK094995 / DK / NIDDK NIH HHS / United States / / Wellcome Trust / United Kingdom R37 DK030292 / DK / NIDDK NIH HHS / United States U01 AI095542 / AI / NIAID NIH HHS / United States |