induces gut intraepithelial CD4CD8αα T cells.

Title induces gut intraepithelial CD4CD8αα T cells.
Publication TypeJournal Article
Year of Publication2017
AuthorsCervantes-Barragan, L, Chai, JN, Tianero, MDiarey, Di Luccia, B, Ahern, PP, Merriman, J, Cortez, VS, Caparon, MG, Donia, MS, Gilfillan, S, Cella, M, Gordon, JI, Hsieh, C-S, Colonna, M
JournalScience
Volume357
Issue6353
Pagination806-810
Date Published2017 08 25
ISSN1095-9203
KeywordsAnimals, Basic Helix-Loop-Helix Transcription Factors, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Down-Regulation, Gastrointestinal Microbiome, Germ-Free Life, Indoles, Intestinal Mucosa, Intestine, Small, Lactobacillus reuteri, Mice, Mice, Inbred C57BL, Receptors, Aryl Hydrocarbon, Transcription Factors, Tryptophan
Abstract

<p>The small intestine contains CD4CD8αα double-positive intraepithelial lymphocytes (DP IELs), which originate from intestinal CD4 T cells through down-regulation of the transcription factor Thpok and have regulatory functions. DP IELs are absent in germ-free mice, which suggests that their differentiation depends on microbial factors. We found that DP IEL numbers in mice varied in different vivaria, correlating with the presence of This species induced DP IELs in germ-free mice and conventionally-raised mice lacking these cells. did not shape the DP-IEL-TCR (TCR, T cell receptor) repertoire but generated indole derivatives of tryptophan that activated the aryl-hydrocarbon receptor in CD4 T cells, allowing Thpok down-regulation and differentiation into DP IELs. Thus, , together with a tryptophan-rich diet, can reprogram intraepithelial CD4 T cells into immunoregulatory T cells.</p>

DOI10.1126/science.aah5825
Alternate JournalScience
PubMed ID28775213
PubMed Central IDPMC5687812
Grant ListR01 DK103039 / DK / NIDDK NIH HHS / United States
R01 CA176695 / CA / NCI NIH HHS / United States
R01 DK030292 / DK / NIDDK NIH HHS / United States
DP2 AI124441 / AI / NIAID NIH HHS / United States
R01 AI070759 / AI / NIAID NIH HHS / United States
R01 DK094995 / DK / NIDDK NIH HHS / United States
/ / Wellcome Trust / United Kingdom
R37 DK030292 / DK / NIDDK NIH HHS / United States
U01 AI095542 / AI / NIAID NIH HHS / United States