The Impact of Space and Time on the Functional Output of the Genome.

TitleThe Impact of Space and Time on the Functional Output of the Genome.
Publication TypeJournal Article
Year of Publication2022
AuthorsNollmann, M, Bennabi, I, Götz, M, Gregor, T
JournalCold Spring Harb Perspect Biol
Volume14
Issue4
Date Published2022 05 17
ISSN1943-0264
KeywordsCell Nucleus, Gene Expression Regulation, Genome, Genomics
Abstract

<p>Over the past two decades, it has become clear that the multiscale spatial and temporal organization of the genome has important implications for nuclear function. This review centers on insights gained from recent advances in light microscopy on our understanding of transcription. We discuss spatial and temporal aspects that shape nuclear order and their consequences on regulatory components, focusing on genomic scales most relevant to function. The emerging picture is that spatiotemporal constraints increase the complexity in transcriptional regulation, highlighting new challenges, such as uncertainty about how information travels from molecular factors through the genome and space to generate a functional output.</p>

DOI10.1101/cshperspect.a040378
Alternate JournalCold Spring Harb Perspect Biol
PubMed ID34230036
PubMed Central IDPMC8733053
Grant ListR01 GM097275 / GM / NIGMS NIH HHS / United States
U01 DA047730 / DA / NIDA NIH HHS / United States
U01 DK127429 / DK / NIDDK NIH HHS / United States
U01 EB021239 / EB / NIBIB NIH HHS / United States