Impact of paternal education on epigenetic ageing in adolescence and mid-adulthood: a multi-cohort study in the USA and Mexico.

TitleImpact of paternal education on epigenetic ageing in adolescence and mid-adulthood: a multi-cohort study in the USA and Mexico.
Publication TypeJournal Article
Year of Publication2021
AuthorsJoyce, BT, Gao, T, Koss, K, Zheng, Y, Cardenas, A, Heiss, J, Just, A, Zhang, K, van Horn, L, Allen, NBai, Greenland, P, Cohen, S, Gordon-Larsen, P, Mitchell, C, McLanahan, S, Schneper, L, Notterman, D, Rifas-Shiman, SL, Oken, E, Hivert, M-F, Wright, R, Baccarelli, A, Lloyd-Jones, D, Hou, L
JournalInt J Epidemiol
Date Published2021/09/17
ISSN1464-3685
Abstract

BACKGROUND: Both parental and neighbourhood socio-economic status (SES) are linked to poorer health independently of personal SES measures, but the biological mechanisms are unclear. Our objective was to examine these influences via epigenetic age acceleration (EAA)-the discrepancy between chronological and epigenetic ages.

METHODS: We examined three USA-based [Coronary Artery Risk Disease in Adults (CARDIA) study, Fragile Families and Child Wellbeing Study (FFCWS) and Programming Research in Obesity, Growth, Environment and Social Stressors (PROGRESS)] and one Mexico-based (Project Viva) cohort. DNA methylation was measured using Illumina arrays, personal/parental SES by questionnaire and neighbourhood disadvantage from geocoded address. In CARDIA, we examined the most strongly associated personal, parental and neighbourhood SES measures with EAA (Hannum's method) at study years 15 and 20 separately and combined using a generalized estimating equation (GEE) and compared with other EAA measures (Horvath's EAA, PhenoAge and GrimAge calculators, and DunedinPoAm).

RESULTS: EAA was associated with paternal education in CARDIA [GEEs: βsome college = -1.01 years (-1.91, -0.11) and β

CONCLUSIONS: These findings suggest that EAA captures epigenetic impacts of paternal education independently of personal SES later in life. Longitudinal studies should explore these associations at different life stages and link them to health outcomes. EAA could be a useful biomarker of SES-associated health and provide important insight into the pathogenesis and prevention of chronic disease.

DOI10.1093/ije/dyab196
Alternate JournalInt J Epidemiol
PubMed ID34534313
Grant ListHHSN268201800005I / HL / NHLBI NIH HHS / United States
HHSN268201800003I / HL / NHLBI NIH HHS / United States
HHSN268201800006I / HL / NHLBI NIH HHS / United States
HHSN268201800004I / HL / NHLBI NIH HHS / United States
AG0005 / / Intramural Research Program of the National Institute on Aging (NIA) and an intra-agency agreement between NIA and NHLBI /
17SFRN33700278 and 14SFRN20790000 / / American Heart Association /
/ / Northwestern University and Lurie Children's Hospital /
R01HD36916, R01HD39135, R01HD40421 and R01HD076592 / NH / NIH HHS / United States
R01 HL 111108, R01 NR013945, R01 HD 034568, UH3 OD023286 and R01 AI102960 / NH / NIH HHS / United States
K23ES022242, R01ES014930, R01ES013744, R01ES020268, P42ES016454, T32ES007069, R01ES000001 and K99ES020346 / / NIH-NIEHS /
/ / Leaves of Grass Foundation and the Klarman Scholars Program at Beth Israel Deaconess Medical Center /