Imaging developmental cell cycles.

TitleImaging developmental cell cycles.
Publication TypeJournal Article
Year of Publication2021
AuthorsKohrman, AQ, Kim-Yip, RP, Posfai, E
JournalBiophys J
Volume120
Issue19
Pagination4149-4161
Date Published2021 10 05
ISSN1542-0086
KeywordsBiosensing Techniques, Cell Cycle, Cell Tracking
Abstract

<p>The last decade has seen a major expansion in development of live biosensors, the tools needed to genetically encode them into model organisms, and the microscopic techniques used to visualize them. When combined, these offer us powerful tools with which to make fundamental discoveries about complex biological processes. In this review, we summarize the availability of biosensors to visualize an essential cellular process, the cell cycle, and the techniques for single-cell tracking and quantification of these reporters. We also highlight studies investigating the connection of cellular behavior to the cell cycle, particularly through live imaging, and anticipate exciting discoveries with the combination of these technologies in developmental contexts.</p>

DOI10.1016/j.bpj.2021.04.035
Alternate JournalBiophys J
PubMed ID33964274
PubMed Central IDPMC8516676