Human organoids: a new dimension in cell biology. Author Ruth Lehmann, Connie Lee, Erika Shugart, Marta Benedetti, R Alta Charo, Zev Gartner, Brigid Hogan, Jürgen Knoblich, Celeste Nelson, Kevin Wilson Publication Year 2019 Type Journal Article Abstract Organoids derived from stem cells or tissues in culture can develop into structures that resemble the in vivo anatomy and physiology of intact organs. Human organoid cultures provide the potential to study human development and model disease processes with the same scrutiny and depth of analysis customary for research with nonhuman model organisms. Resembling the complexity of the actual tissue or organ, patient-derived human organoid studies may accelerate medical research, creating new opportunities for tissue engineering and regenerative medicine, generating knowledge and tools for preclinical studies, including drug development and testing. Biologists are drawn to this system as a new "model organism" to study complex disease phenotypes and genetic variability among individuals using patient-derived tissues. The American Society for Cell Biology convened a task force to report on the potential, challenges, and limitations for human organoid research. The task force suggests ways to ease the entry for new researchers into the field and how to facilitate broader use of this new model organism within the research community. This includes guidelines for reproducibility, culturing, sharing of patient materials, patient consent, training, and communication with the public. Keywords Animals, Humans, Models, Biological, Reproducibility of Results, Stem Cells, Cell Culture Techniques, Biomedical Research, Tissue Engineering, Organoids, Regenerative Medicine Journal Mol Biol Cell Volume 30 Issue 10 Pages 1129-1137 Date Published 2019 May 01 ISSN Number 1939-4586 DOI 10.1091/mbc.E19-03-0135 Alternate Journal Mol Biol Cell PMCID PMC6724519 PMID 31034354 PubMedPubMed CentralGoogle ScholarBibTeXEndNote X3 XML