Host Innate Immune Response and Viral Immune Evasion During Alphaherpesvirus Infection.

Publication Year
2021

Type

Journal Article
Abstract

Both the development of the mammalian innate immune system and the antagonistic strategies acquired by alphaherpesviruses to dismantle it have been shaped by co-evolving virus-host interactions over millions of years. Here, we review mechanisms employed by mammalian cells to detect pathogen molecules, such as viral glycoproteins and nucleic acids, and induce innate immune signaling upon infection with alphaherpesviruses. We further explore strategies acquired by these viruses to bypass immune detection and activation, thereby supporting virus replication and spread. Finally, we discuss the contributions of advanced 'omics' and microscopy methods to these discoveries in immune signaling and highlight emerging technologies that can help to further our understanding of the dynamic interplay between host innate immune responses and virus immune evasion.

Journal
Curr Issues Mol Biol
Volume
42
Pages
635-686
Date Published
2021
ISSN Number
1467-3045
Alternate Journal
Curr Issues Mol Biol
PMCID
PMC8301600
PMID
33640867