Host Innate Immune Response and Viral Immune Evasion During Alphaherpesvirus Infection.

TitleHost Innate Immune Response and Viral Immune Evasion During Alphaherpesvirus Infection.
Publication TypeJournal Article
Year of Publication2021
AuthorsLum, KK, Cristea, IM
JournalCurr Issues Mol Biol
Volume42
Pagination635-686
Date Published2021
ISSN1467-3045
Abstract

<p>Both the development of the mammalian innate immune system and the antagonistic strategies acquired by alphaherpesviruses to dismantle it have been shaped by co-evolving virus-host interactions over millions of years. Here, we review mechanisms employed by mammalian cells to detect pathogen molecules, such as viral glycoproteins and nucleic acids, and induce innate immune signaling upon infection with alphaherpesviruses. We further explore strategies acquired by these viruses to bypass immune detection and activation, thereby supporting virus replication and spread. Finally, we discuss the contributions of advanced 'omics' and microscopy methods to these discoveries in immune signaling and highlight emerging technologies that can help to further our understanding of the dynamic interplay between host innate immune responses and virus immune evasion.</p>

DOI10.21775/cimb.042.635
Alternate JournalCurr Issues Mol Biol
PubMed ID33640867