| Title | Highly Potent, Chemically Stable Quorum Sensing Agonists for |
| Publication Type | Journal Article |
| Year of Publication | 2014 |
| Authors | Perez, LJ, Karagounis, TK, Hurley, A, Bassler, BL, Semmelhack, MF |
| Journal | Chem Sci |
| Volume | 5 |
| Issue | 1 |
| Pagination | 151-155 |
| Date Published | 2014 Jan 01 |
| ISSN | 2041-6520 |
| Abstract | <p>In the pathogen, initiation of bacterial quorum sensing pathways serves to suppress virulence. We describe herein a potent and chemically stable small molecule agonist of quorum sensing, which was identified through rational drug design based on the native quorum sensing signal. This novel agonist may serve as a useful lead compound for the control of virulence in .</p> |
| DOI | 10.1039/C3SC52572D |
| Alternate Journal | Chem Sci |
| PubMed ID | 24436778 |
| PubMed Central ID | PMC3890260 |
| Grant List | R01 AI054442 / AI / NIAID NIH HHS / United States R01 GM065859 / GM / NIGMS NIH HHS / United States T32 GM007388 / GM / NIGMS NIH HHS / United States |
