Title | Highly Potent, Chemically Stable Quorum Sensing Agonists for |
Publication Type | Journal Article |
Year of Publication | 2014 |
Authors | Perez, LJ, Karagounis, TK, Hurley, A, Bassler, BL, Semmelhack, MF |
Journal | Chem Sci |
Volume | 5 |
Issue | 1 |
Pagination | 151-155 |
Date Published | 2014 Jan 01 |
ISSN | 2041-6520 |
Abstract | <p>In the pathogen, initiation of bacterial quorum sensing pathways serves to suppress virulence. We describe herein a potent and chemically stable small molecule agonist of quorum sensing, which was identified through rational drug design based on the native quorum sensing signal. This novel agonist may serve as a useful lead compound for the control of virulence in .</p> |
DOI | 10.1039/C3SC52572D |
Alternate Journal | Chem Sci |
PubMed ID | 24436778 |
PubMed Central ID | PMC3890260 |
Grant List | R01 AI054442 / AI / NIAID NIH HHS / United States R01 GM065859 / GM / NIGMS NIH HHS / United States T32 GM007388 / GM / NIGMS NIH HHS / United States |