Title | A high-stringency blueprint of the human proteome. |
Publication Type | Journal Article |
Year of Publication | 2020 |
Authors | Adhikari, S, Nice, EC, Deutsch, EW, Lane, L, Omenn, GS, Pennington, SR, Paik, Y-K, Overall, CM, Corrales, FJ, Cristea, IM, Van Eyk, JE, Uhlén, M, Lindskog, C, Chan, DW, Bairoch, A, Waddington, JC, Justice, JL, LaBaer, J, Rodriguez, H, He, F, Kostrzewa, M, Ping, P, Gundry, RL, Stewart, P, Srivastava, S, Srivastava, S, Nogueira, FCS, Domont, GB, Vandenbrouck, Y, P Y Lam, M, Wennersten, S, Vizcaino, JAntonio, Wilkins, M, Schwenk, JM, Lundberg, E, Bandeira, N, Marko-Varga, G, Weintraub, ST, Pineau, C, Kusebauch, U, Moritz, RL, Ahn, SBeom, Palmblad, M, Snyder, MP, Aebersold, R, Baker, MS |
Journal | Nat Commun |
Volume | 11 |
Issue | 1 |
Pagination | 5301 |
Date Published | 2020 Oct 16 |
ISSN | 2041-1723 |
Keywords | Disease, Human Genome Project, Humans, Proteome, Proteomics |
Abstract | <p>The Human Proteome Organization (HUPO) launched the Human Proteome Project (HPP) in 2010, creating an international framework for global collaboration, data sharing, quality assurance and enhancing accurate annotation of the genome-encoded proteome. During the subsequent decade, the HPP established collaborations, developed guidelines and metrics, and undertook reanalysis of previously deposited community data, continuously increasing the coverage of the human proteome. On the occasion of the HPP's tenth anniversary, we here report a 90.4% complete high-stringency human proteome blueprint. This knowledge is essential for discerning molecular processes in health and disease, as we demonstrate by highlighting potential roles the human proteome plays in our understanding, diagnosis and treatment of cancers, cardiovascular and infectious diseases.</p> |
DOI | 10.1038/s41467-020-19045-9 |
Alternate Journal | Nat Commun |
PubMed ID | 33067450 |
PubMed Central ID | PMC7568584 |
Grant List | WT101477MA / WT_ / Wellcome Trust / United Kingdom R24 GM127667 / GM / NIGMS NIH HHS / United States U24 CA210985 / CA / NCI NIH HHS / United States U19 AG023122 / AG / NIA NIH HHS / United States U24 CA210967 / CA / NCI NIH HHS / United States R01 GM087221 / GM / NIGMS NIH HHS / United States R01 GM114141 / GM / NIGMS NIH HHS / United States FDN14840 / / CIHR / Canada U24 CA115102 / CA / NCI NIH HHS / United States F20-01013 / / CIHR / Canada P30 ES017885 / ES / NIEHS NIH HHS / United States R24 GM137776 / GM / NIGMS NIH HHS / United States / WT_ / Wellcome Trust / United Kingdom 208391/Z/17/Z / WT_ / Wellcome Trust / United Kingdom |