A high-stringency blueprint of the human proteome.

TitleA high-stringency blueprint of the human proteome.
Publication TypeJournal Article
Year of Publication2020
AuthorsAdhikari, S, Nice, EC, Deutsch, EW, Lane, L, Omenn, GS, Pennington, SR, Paik, Y-K, Overall, CM, Corrales, FJ, Cristea, IM, Van Eyk, JE, Uhlén, M, Lindskog, C, Chan, DW, Bairoch, A, Waddington, JC, Justice, JL, LaBaer, J, Rodriguez, H, He, F, Kostrzewa, M, Ping, P, Gundry, RL, Stewart, P, Srivastava, S, Srivastava, S, Nogueira, FCS, Domont, GB, Vandenbrouck, Y, P Y Lam, M, Wennersten, S, Vizcaino, JAntonio, Wilkins, M, Schwenk, JM, Lundberg, E, Bandeira, N, Marko-Varga, G, Weintraub, ST, Pineau, C, Kusebauch, U, Moritz, RL, Ahn, SBeom, Palmblad, M, Snyder, MP, Aebersold, R, Baker, MS
JournalNat Commun
Volume11
Issue1
Pagination5301
Date Published2020 10 16
ISSN2041-1723
KeywordsDisease, Human Genome Project, Humans, Proteome, Proteomics
Abstract

<p>The Human Proteome Organization (HUPO) launched the Human Proteome Project (HPP) in 2010, creating an international framework for global collaboration, data sharing, quality assurance and enhancing accurate annotation of the genome-encoded proteome. During the subsequent decade, the HPP established collaborations, developed guidelines and metrics, and undertook reanalysis of previously deposited community data, continuously increasing the coverage of the human proteome. On the occasion of the HPP's tenth anniversary, we here report a 90.4% complete high-stringency human proteome blueprint. This knowledge is essential for discerning molecular processes in health and disease, as we demonstrate by highlighting potential roles the human proteome plays in our understanding, diagnosis and treatment of cancers, cardiovascular and infectious diseases.</p>

DOI10.1038/s41467-020-19045-9
Alternate JournalNat Commun
PubMed ID33067450
PubMed Central IDPMC7568584
Grant ListWT101477MA / WT_ / Wellcome Trust / United Kingdom
R24 GM127667 / GM / NIGMS NIH HHS / United States
U24 CA210985 / CA / NCI NIH HHS / United States
U19 AG023122 / AG / NIA NIH HHS / United States
U24 CA210967 / CA / NCI NIH HHS / United States
R01 GM087221 / GM / NIGMS NIH HHS / United States
R01 GM114141 / GM / NIGMS NIH HHS / United States
FDN14840 / / CIHR / Canada
U24 CA115102 / CA / NCI NIH HHS / United States
F20-01013 / / CIHR / Canada
P30 ES017885 / ES / NIEHS NIH HHS / United States
/ WT_ / Wellcome Trust / United Kingdom
208391/Z/17/Z / WT_ / Wellcome Trust / United Kingdom