Hepatocarcinogenesis associated with hepatitis B, delta and C viruses.

Publication Year
2016

Type

Journal Article
Abstract

Globally, over half a billion people are persistently infected with hepatitis B (HBV) and/or hepatitis C viruses. Chronic HBV and HCV infection frequently lead to fibrosis, cirrhosis and hepatocellular carcinoma (HCC). Co-infections with hepatitis delta virus (HDV), a subviral satellite requiring HBV for its propagation, accelerates the progression of liver disease toward HCC. The mechanisms by which these viruses cause malignant transformation, culminating in HCC, remain incompletely understood, partially due to the lack of adequate experimental models for dissecting these complex disease processes in vivo.

Journal
Curr Opin Virol
Volume
20
Pages
1-10
Date Published
2016 Oct
ISSN Number
1879-6265
Alternate Journal
Curr Opin Virol
PMCID
PMC5508050
PMID
27504999