Hepatocarcinogenesis associated with hepatitis B, delta and C viruses. Author Elham Shirvani-Dastgerdi, Robert Schwartz, Alexander Ploss Publication Year 2016 Type Journal Article Abstract Globally, over half a billion people are persistently infected with hepatitis B (HBV) and/or hepatitis C viruses. Chronic HBV and HCV infection frequently lead to fibrosis, cirrhosis and hepatocellular carcinoma (HCC). Co-infections with hepatitis delta virus (HDV), a subviral satellite requiring HBV for its propagation, accelerates the progression of liver disease toward HCC. The mechanisms by which these viruses cause malignant transformation, culminating in HCC, remain incompletely understood, partially due to the lack of adequate experimental models for dissecting these complex disease processes in vivo. Keywords Humans, Carcinogenesis, Carcinoma, Hepatocellular, Hepatitis B, Chronic, Hepatitis C, Chronic, Hepatitis D, Chronic, Liver Neoplasms Journal Curr Opin Virol Volume 20 Pages 1-10 Date Published 2016 Oct ISSN Number 1879-6265 DOI 10.1016/j.coviro.2016.07.009 Alternate Journal Curr Opin Virol PMCID PMC5508050 PMID 27504999 PubMedPubMed CentralGoogle ScholarBibTeXEndNote X3 XML