Hepatocarcinogenesis associated with hepatitis B, delta and C viruses.

TitleHepatocarcinogenesis associated with hepatitis B, delta and C viruses.
Publication TypeJournal Article
Year of Publication2016
AuthorsShirvani-Dastgerdi, E, Schwartz, RE, Ploss, A
JournalCurr Opin Virol
Volume20
Pagination1-10
Date Published2016 10
ISSN1879-6265
KeywordsCarcinogenesis, Carcinoma, Hepatocellular, Hepatitis B, Chronic, Hepatitis C, Chronic, Hepatitis D, Chronic, Humans, Liver Neoplasms
Abstract

<p>Globally, over half a billion people are persistently infected with hepatitis B (HBV) and/or hepatitis C viruses. Chronic HBV and HCV infection frequently lead to fibrosis, cirrhosis and hepatocellular carcinoma (HCC). Co-infections with hepatitis delta virus (HDV), a subviral satellite requiring HBV for its propagation, accelerates the progression of liver disease toward HCC. The mechanisms by which these viruses cause malignant transformation, culminating in HCC, remain incompletely understood, partially due to the lack of adequate experimental models for dissecting these complex disease processes in vivo.</p>

DOI10.1016/j.coviro.2016.07.009
Alternate JournalCurr Opin Virol
PubMed ID27504999
PubMed Central IDPMC5508050
Grant ListK08 DK101754 / DK / NIDDK NIH HHS / United States
R01 AI079031 / AI / NIAID NIH HHS / United States
R01 AI107301 / AI / NIAID NIH HHS / United States
R21 AI117213 / AI / NIAID NIH HHS / United States