Title | Hepatocarcinogenesis associated with hepatitis B, delta and C viruses. |
Publication Type | Journal Article |
Year of Publication | 2016 |
Authors | Shirvani-Dastgerdi, E, Schwartz, RE, Ploss, A |
Journal | Curr Opin Virol |
Volume | 20 |
Pagination | 1-10 |
Date Published | 2016 Oct |
ISSN | 1879-6265 |
Keywords | Carcinogenesis, Carcinoma, Hepatocellular, Hepatitis B, Chronic, Hepatitis C, Chronic, Hepatitis D, Chronic, Humans, Liver Neoplasms |
Abstract | <p>Globally, over half a billion people are persistently infected with hepatitis B (HBV) and/or hepatitis C viruses. Chronic HBV and HCV infection frequently lead to fibrosis, cirrhosis and hepatocellular carcinoma (HCC). Co-infections with hepatitis delta virus (HDV), a subviral satellite requiring HBV for its propagation, accelerates the progression of liver disease toward HCC. The mechanisms by which these viruses cause malignant transformation, culminating in HCC, remain incompletely understood, partially due to the lack of adequate experimental models for dissecting these complex disease processes in vivo.</p> |
DOI | 10.1016/j.coviro.2016.07.009 |
Alternate Journal | Curr Opin Virol |
PubMed ID | 27504999 |
PubMed Central ID | PMC5508050 |
Grant List | K08 DK101754 / DK / NIDDK NIH HHS / United States R01 AI079031 / AI / NIAID NIH HHS / United States R01 AI107301 / AI / NIAID NIH HHS / United States R21 AI117213 / AI / NIAID NIH HHS / United States |