Guidelines and definitions for research on epithelial-mesenchymal transition. Author Jing Yang, Parker Antin, Geert Berx, Cédric Blanpain, Thomas Brabletz, Marianne Bronner, Kyra Campbell, Amparo Cano, Jordi Casanova, Gerhard Christofori, Shoukat Dedhar, Rik Derynck, Heide Ford, Jonas Fuxe, Antonio de Herreros, Gregory Goodall, Anna-Katerina Hadjantonakis, Ruby Huang, Chaya Kalcheim, Raghu Kalluri, Yibin Kang, Yeesim Khew-Goodall, Herbert Levine, Jinsong Liu, Gregory Longmore, Sendurai Mani, Joan Massagué, Roberto Mayor, David McClay, Keith Mostov, Donald Newgreen, M Angela Nieto, Alain Puisieux, Raymond Runyan, Pierre Savagner, Ben Stanger, Marc Stemmler, Yoshiko Takahashi, Masatoshi Takeichi, Eric Theveneau, Jean Thiery, Erik Thompson, Robert Weinberg, Elizabeth Williams, Jianhua Xing, Binhua Zhou, Guojun Sheng, EMT International Association (TEMTIA) Publication Year 2020 Type Journal Article Abstract Epithelial-mesenchymal transition (EMT) encompasses dynamic changes in cellular organization from epithelial to mesenchymal phenotypes, which leads to functional changes in cell migration and invasion. EMT occurs in a diverse range of physiological and pathological conditions and is driven by a conserved set of inducing signals, transcriptional regulators and downstream effectors. With over 5,700 publications indexed by Web of Science in 2019 alone, research on EMT is expanding rapidly. This growing interest warrants the need for a consensus among researchers when referring to and undertaking research on EMT. This Consensus Statement, mediated by 'the EMT International Association' (TEMTIA), is the outcome of a 2-year-long discussion among EMT researchers and aims to both clarify the nomenclature and provide definitions and guidelines for EMT research in future publications. We trust that these guidelines will help to reduce misunderstanding and misinterpretation of research data generated in various experimental models and to promote cross-disciplinary collaboration to identify and address key open questions in this research field. While recognizing the importance of maintaining diversity in experimental approaches and conceptual frameworks, we emphasize that lasting contributions of EMT research to increasing our understanding of developmental processes and combatting cancer and other diseases depend on the adoption of a unified terminology to describe EMT. Keywords Animals, Humans, Cell Movement, Developmental Biology, Terminology as Topic, Neoplasms, Epithelial-Mesenchymal Transition, Biomedical Research, Cell Plasticity, Consensus Journal Nat Rev Mol Cell Biol Volume 21 Issue 6 Pages 341-352 Date Published 2020 Jun ISSN Number 1471-0080 DOI 10.1038/s41580-020-0237-9 Alternate Journal Nat Rev Mol Cell Biol PMCID PMC7250738 PMID 32300252 PubMedPubMed CentralGoogle ScholarBibTeXEndNote X3 XML