Globularity and protein function.

TitleGlobularity and protein function.
Publication TypeJournal Article
Year of Publication2000
AuthorsCarey, J
JournalJ Biomol Struct Dyn
Volume17 Suppl 1
Date Published2000
KeywordsHydrophobic and Hydrophilic Interactions, Protein Conformation, Protein Folding, Protein Structure, Secondary, Protein Structure, Tertiary, Proteins

<p>Abstract The forces that direct protein folding lead naturally to native proteins and protein domains that are typically, to a first approximation, globular-spherical and compact, with a relatively clear distinction between the hydrophobic inside and polar outside. The near-universality of these features of protein structures sharpens our focus on some apparent exceptions. Consideration of the structure/function link in some of the exceptional cases provides some insights into our views of protein function.</p>

Alternate JournalJ Biomol Struct Dyn
PubMed ID22607410