Globularity and protein function.

TitleGlobularity and protein function.
Publication TypeJournal Article
Year of Publication2000
AuthorsCarey, J
JournalJ Biomol Struct Dyn
Volume17 Suppl 1
Date Published2000
KeywordsHydrophobic and Hydrophilic Interactions, Protein Conformation, Protein Folding, Protein Structure, Secondary, Protein Structure, Tertiary, Proteins

Abstract The forces that direct protein folding lead naturally to native proteins and protein domains that are typically, to a first approximation, globular-spherical and compact, with a relatively clear distinction between the hydrophobic inside and polar outside. The near-universality of these features of protein structures sharpens our focus on some apparent exceptions. Consideration of the structure/function link in some of the exceptional cases provides some insights into our views of protein function.

Alternate JournalJ. Biomol. Struct. Dyn.
PubMed ID22607410