Title | Genome mining for lasso peptides: past, present, and future. |
Publication Type | Journal Article |
Year of Publication | 2019 |
Authors | Cheung-Lee, WLing, A Link, J |
Journal | J Ind Microbiol Biotechnol |
Volume | 46 |
Issue | 9-10 |
Pagination | 1371-1379 |
Date Published | 2019 Oct |
ISSN | 1476-5535 |
Keywords | Genome, Humans, Multigene Family, Peptides |
Abstract | <p>Over the course of roughly a decade, the lasso peptide field has been transformed. Whereas new compounds were discovered infrequently via activity-driven approaches, now, the vast majority of lasso peptide discovery is driven by genome-mining approaches. This paper starts with a historical overview of the first genome-mining approaches for lasso peptide discovery, and then covers new tools that have emerged. Several examples of novel lasso peptides that have been discovered via genome mining are presented as are examples of new enzymes found associated with lasso peptide gene clusters. Finally, this paper concludes with future directions and unsolved challenges in lasso peptide genome mining.</p> |
DOI | 10.1007/s10295-019-02197-z |
Alternate Journal | J Ind Microbiol Biotechnol |
PubMed ID | 31165971 |
PubMed Central ID | PMC6989040 |
Grant List | R01 GM107036 / GM / NIGMS NIH HHS / United States |