Genome mining for lasso peptides: past, present, and future.

Publication Year
2019

Type

Journal Article
Abstract

Over the course of roughly a decade, the lasso peptide field has been transformed. Whereas new compounds were discovered infrequently via activity-driven approaches, now, the vast majority of lasso peptide discovery is driven by genome-mining approaches. This paper starts with a historical overview of the first genome-mining approaches for lasso peptide discovery, and then covers new tools that have emerged. Several examples of novel lasso peptides that have been discovered via genome mining are presented as are examples of new enzymes found associated with lasso peptide gene clusters. Finally, this paper concludes with future directions and unsolved challenges in lasso peptide genome mining.

Journal
J Ind Microbiol Biotechnol
Volume
46
Issue
9-10
Pages
1371-1379
Date Published
2019 Oct
ISSN Number
1476-5535
Alternate Journal
J Ind Microbiol Biotechnol
PMCID
PMC6989040
PMID
31165971