Genome mining for lasso peptides: past, present, and future.

TitleGenome mining for lasso peptides: past, present, and future.
Publication TypeJournal Article
Year of Publication2019
AuthorsCheung-Lee, WLing, A Link, J
JournalJ Ind Microbiol Biotechnol
Volume46
Issue9-10
Pagination1371-1379
Date Published2019 Oct
ISSN1476-5535
KeywordsGenome, Humans, Multigene Family, Peptides
Abstract

<p>Over the course of roughly a decade, the lasso peptide field has been transformed. Whereas new compounds were discovered infrequently via activity-driven approaches, now, the vast majority of lasso peptide discovery is driven by genome-mining approaches. This paper starts with a historical overview of the first genome-mining approaches for lasso peptide discovery, and then covers new tools that have emerged. Several examples of novel lasso peptides that have been discovered via genome mining are presented as are examples of new enzymes found associated with lasso peptide gene clusters. Finally, this paper concludes with future directions and unsolved challenges in lasso peptide genome mining.</p>

DOI10.1007/s10295-019-02197-z
Alternate JournalJ. Ind. Microbiol. Biotechnol.
PubMed ID31165971
PubMed Central IDPMC6989040
Grant ListR01 GM107036 / GM / NIGMS NIH HHS / United States
GM107036 / / NIH/NIGMS /