Genetic Screens to Analyze Pattern Formation of Egg and Embryo in : A Personal History. Author Trudi Schüpbach Publication Year 2019 Type Journal Article Abstract In development, the axes of the egg and future embryo are established during oogenesis. To learn about the underlying genetic and molecular pathways that lead to axis formation, I conducted a large-scale genetic screen at the beginning of my independent career. This led to the eventual understanding that both anterior-posterior and dorsal-ventral pattern information is transmitted from the oocyte to the surrounding follicle cells and in turn from the follicle cells back to the oocyte. How I came to conduct this screen and what further insights were gained by studying the mutants isolated in the screen are the topics of this autobiographical article. Keywords Animals, Drosophila Proteins, Female, Male, Drosophila melanogaster, Gene Expression Regulation, Developmental, Ovum, Embryo, Nonmammalian, History, 20th Century, History, 21st Century, United States, Oocytes, Ovary, Body Patterning, ErbB Receptors, Receptors, Invertebrate Peptide, Genetics, Sex Determination Analysis, Sex Determination Processes Journal Annu Rev Genet Volume 53 Pages 1-18 Date Published 2019 Dec 03 ISSN Number 1545-2948 DOI 10.1146/annurev-genet-112618-043708 Alternate Journal Annu Rev Genet PMID 31794267 PubMedGoogle ScholarBibTeXEndNote X3 XML