Genetic Screens to Analyze Pattern Formation of Egg and Embryo in : A Personal History.

Publication Year
2019

Type

Journal Article
Abstract

In development, the axes of the egg and future embryo are established during oogenesis. To learn about the underlying genetic and molecular pathways that lead to axis formation, I conducted a large-scale genetic screen at the beginning of my independent career. This led to the eventual understanding that both anterior-posterior and dorsal-ventral pattern information is transmitted from the oocyte to the surrounding follicle cells and in turn from the follicle cells back to the oocyte. How I came to conduct this screen and what further insights were gained by studying the mutants isolated in the screen are the topics of this autobiographical article.

Journal
Annu Rev Genet
Volume
53
Pages
1-18
Date Published
2019 Dec 03
ISSN Number
1545-2948
Alternate Journal
Annu Rev Genet
PMID
31794267