Genetic Screens to Analyze Pattern Formation of Egg and Embryo in : A Personal History.

TitleGenetic Screens to Analyze Pattern Formation of Egg and Embryo in : A Personal History.
Publication TypeJournal Article
Year of Publication2019
AuthorsSchüpbach, T
JournalAnnu Rev Genet
Volume53
Pagination1-18
Date Published2019 12 03
ISSN1545-2948
KeywordsAnimals, Body Patterning, Drosophila melanogaster, Drosophila Proteins, Embryo, Nonmammalian, ErbB Receptors, Female, Gene Expression Regulation, Developmental, Genetics, History, 20th Century, History, 21st Century, Male, Oocytes, Ovary, Ovum, Receptors, Invertebrate Peptide, Sex Determination Analysis, Sex Determination Processes, United States
Abstract

<p>In development, the axes of the egg and future embryo are established during oogenesis. To learn about the underlying genetic and molecular pathways that lead to axis formation, I conducted a large-scale genetic screen at the beginning of my independent career. This led to the eventual understanding that both anterior-posterior and dorsal-ventral pattern information is transmitted from the oocyte to the surrounding follicle cells and in turn from the follicle cells back to the oocyte. How I came to conduct this screen and what further insights were gained by studying the mutants isolated in the screen are the topics of this autobiographical article.</p>

DOI10.1146/annurev-genet-112618-043708
Alternate JournalAnnu. Rev. Genet.
PubMed ID31794267