Generation of Human Liver Chimeric Mice for the Study of Human Hepatotropic Pathogens.

TitleGeneration of Human Liver Chimeric Mice for the Study of Human Hepatotropic Pathogens.
Publication TypeJournal Article
Year of Publication2016
Authorsvon Schaewen, M, Hrebikova, G, Ploss, A
JournalMethods Mol Biol
Volume1438
Pagination79-101
Date Published2016
ISSN1940-6029
KeywordsAnimals, Cryopreservation, Disease Models, Animal, Hepatocytes, Humans, Liver, Liver Regeneration, Mice, Transplantation Chimera, Transplantation, Heterologous
Abstract

<p>Human liver chimeric mice have become valuable tools for the study of human hepatotropic pathogens and for the investigation of metabolism and pharmacokinetics of novel drugs. The evolution of the underlying mouse models has been rapid in the past years. The diverse fields of applications of those model systems and their technical challenges will be discussed in this chapter.</p>

DOI10.1007/978-1-4939-3661-8_5
Alternate JournalMethods Mol. Biol.
PubMed ID27150085
Grant ListR01 AI107301 / AI / NIAID NIH HHS / United States
R21 AI117213 / AI / NIAID NIH HHS / United States
R01 AI079031 / AI / NIAID NIH HHS / United States
R56 AI106005 / AI / NIAID NIH HHS / United States