| Title | Generation of Human Liver Chimeric Mice for the Study of Human Hepatotropic Pathogens. |
| Publication Type | Journal Article |
| Year of Publication | 2016 |
| Authors | von Schaewen, M, Hrebikova, G, Ploss, A |
| Journal | Methods Mol Biol |
| Volume | 1438 |
| Pagination | 79-101 |
| Date Published | 2016 |
| ISSN | 1940-6029 |
| Keywords | Animals, Cryopreservation, Disease Models, Animal, Hepatocytes, Humans, Liver, Liver Regeneration, Mice, Transplantation Chimera, Transplantation, Heterologous |
| Abstract | <p>Human liver chimeric mice have become valuable tools for the study of human hepatotropic pathogens and for the investigation of metabolism and pharmacokinetics of novel drugs. The evolution of the underlying mouse models has been rapid in the past years. The diverse fields of applications of those model systems and their technical challenges will be discussed in this chapter.</p> |
| DOI | 10.1007/978-1-4939-3661-8_5 |
| Alternate Journal | Methods Mol Biol |
| PubMed ID | 27150085 |
| Grant List | R01 AI107301 / AI / NIAID NIH HHS / United States R21 AI117213 / AI / NIAID NIH HHS / United States R01 AI079031 / AI / NIAID NIH HHS / United States R56 AI106005 / AI / NIAID NIH HHS / United States |
