Generation of Human Liver Chimeric Mice for the Study of Human Hepatotropic Pathogens. Author Markus von Schaewen, Gabriela Hrebikova, Alexander Ploss Publication Year 2016 Type Journal Article Abstract Human liver chimeric mice have become valuable tools for the study of human hepatotropic pathogens and for the investigation of metabolism and pharmacokinetics of novel drugs. The evolution of the underlying mouse models has been rapid in the past years. The diverse fields of applications of those model systems and their technical challenges will be discussed in this chapter. Keywords Animals, Disease Models, Animal, Mice, Humans, Hepatocytes, Liver, Transplantation, Heterologous, Cryopreservation, Liver Regeneration, Transplantation Chimera Journal Methods Mol Biol Volume 1438 Pages 79-101 Date Published 2016 ISSN Number 1940-6029 DOI 10.1007/978-1-4939-3661-8_5 Alternate Journal Methods Mol Biol PMID 27150085 PubMedGoogle ScholarBibTeXEndNote X3 XML