Generating tissue topology through remodeling of cell-cell adhesions.

TitleGenerating tissue topology through remodeling of cell-cell adhesions.
Publication TypeJournal Article
Year of Publication2017
AuthorsGoodwin, K, Nelson, CM
JournalExp Cell Res
Volume358
Issue1
Pagination45-51
Date Published2017 09 01
ISSN1090-2422
KeywordsAnimals, Cadherins, Cell Adhesion, Cell Movement, Extracellular Matrix, Humans, Morphogenesis, Tissue Engineering
Abstract

<p>During tissue morphogenesis, cellular rearrangements give rise to a large variety of three-dimensional structures. Final tissue architecture varies greatly across organs, and many develop to include combinations of folds, tubes, and branched networks. To achieve these different tissue geometries, constituent cells must follow different programs that dictate changes in shape and/or migratory behavior. One essential component of these changes is the remodeling of cell-cell adhesions. Invasive migratory behavior and separation between tissues require localized breakdown of cadherin-mediated adhesions. Conversely, tissue folding and fusion require the formation and reinforcement of cell-cell adhesions. Cell-cell adhesion plays a critical role in tissue morphogenesis; its manipulation may therefore prove to be invaluable in generating complex topologies ex vivo. Recapitulating these shapes in engineered tissues would enable a better understanding of how these processes occur in vivo, and may lead to improved design of organs for clinical applications. In this review, we discuss work investigating the formation of folds, tubes, and branched networks with an emphasis on known or possible roles for cell-cell adhesion. We then examine recently developed tools that could be adapted to manipulate cell-cell adhesion in engineered tissues.</p>

DOI10.1016/j.yexcr.2017.03.016
Alternate JournalExp Cell Res
PubMed ID28322823
PubMed Central IDPMC5544595
Grant ListR01 CA187692 / CA / NCI NIH HHS / United States
R01 HL120142 / HL / NHLBI NIH HHS / United States
R21 HL110335 / HL / NHLBI NIH HHS / United States
R21 HL118532 / HL / NHLBI NIH HHS / United States