FNTM: a server for predicting functional networks of tissues in mouse.

TitleFNTM: a server for predicting functional networks of tissues in mouse.
Publication TypeJournal Article
Year of Publication2015
AuthorsGoya, J, Wong, AK, Yao, V, Krishnan, A, Homilius, M, Troyanskaya, OG
JournalNucleic Acids Res
Volume43
IssueW1
PaginationW182-7
Date Published2015 Jul 01
ISSN1362-4962
KeywordsAnimals, Gene Regulatory Networks, Internet, Mice, Organ Specificity, Software
Abstract

<p>Functional Networks of Tissues in Mouse (FNTM) provides biomedical researchers with tissue-specific predictions of functional relationships between proteins in the most widely used model organism for human disease, the laboratory mouse. Users can explore FNTM-predicted functional relationships for their tissues and genes of interest or examine gene function and interaction predictions across multiple tissues, all through an interactive, multi-tissue network browser. FNTM makes predictions based on integration of a variety of functional genomic data, including over 13 000 gene expression experiments, and prior knowledge of gene function. FNTM is an ideal starting point for clinical and translational researchers considering a mouse model for their disease of interest, researchers already working with mouse models who are interested in discovering new genes related to their pathways or phenotypes of interest, and biologists working with other organisms to explore the functional relationships of their genes of interest in specific mouse tissue contexts. FNTM predicts tissue-specific functional relationships in 200 tissues, does not require any registration or installation and is freely available for use at http://fntm.princeton.edu. </p>

DOI10.1093/nar/gkv443
Alternate JournalNucleic Acids Res.
PubMed ID25940632
PubMed Central IDPMC4489275
Grant ListR01 GM071966 / GM / NIGMS NIH HHS / United States
T32 HG003284 / HG / NHGRI NIH HHS / United States
P50 GM071508 / GM / NIGMS NIH HHS / United States
R01 HG005998 / HG / NHGRI NIH HHS / United States