Extracellular Matrix Stiffness Exists in a Feedback Loop that Drives Tumor Progression.

TitleExtracellular Matrix Stiffness Exists in a Feedback Loop that Drives Tumor Progression.
Publication TypeJournal Article
Year of Publication2018
AuthorsSimi, AK, Pang, M-F, Nelson, CM
JournalAdv Exp Med Biol
Volume1092
Pagination57-67
Date Published2018
ISSN0065-2598
Abstract

Cells communicate constantly with their surrounding extracellular matrix (ECM) to maintain homeostasis, using both mechanical and chemical signals. In cancer, abnormal signaling leads to stiffening of the ECM. A stiff microenvironment affects many aspects of the cell, including internal molecular signaling as well as behaviors such as motility and proliferation. Thus, cells and ECM interact in a feedback loop to drive matrix deposition and cross-linking, which alter the mechanical properties of the tissue. Stiffer tissue enhances the invasive potential of a tumor and decreases therapeutic efficacy. This chapter describes how specific molecular effects caused by an abnormally stiff tissue drive macroscopic changes that help determine disease outcome. A complete understanding may foster the generation of new cancer therapies.

DOI10.1007/978-3-319-95294-9_4
Alternate JournalAdv. Exp. Med. Biol.
PubMed ID30368748