Extracellular Matrix Stiffness Exists in a Feedback Loop that Drives Tumor Progression.

Publication Year
2018

Type

Journal Article
Abstract

Cells communicate constantly with their surrounding extracellular matrix (ECM) to maintain homeostasis, using both mechanical and chemical signals. In cancer, abnormal signaling leads to stiffening of the ECM. A stiff microenvironment affects many aspects of the cell, including internal molecular signaling as well as behaviors such as motility and proliferation. Thus, cells and ECM interact in a feedback loop to drive matrix deposition and cross-linking, which alter the mechanical properties of the tissue. Stiffer tissue enhances the invasive potential of a tumor and decreases therapeutic efficacy. This chapter describes how specific molecular effects caused by an abnormally stiff tissue drive macroscopic changes that help determine disease outcome. A complete understanding may foster the generation of new cancer therapies.

Journal
Adv Exp Med Biol
Volume
1092
Pages
57-67
Date Published
2018
ISSN Number
0065-2598
Alternate Journal
Adv Exp Med Biol
PMID
30368748