Title | Exploring and Exploiting Proteome Organization during Viral Infection. |
Publication Type | Journal Article |
Year of Publication | 2017 |
Authors | Beltran, PMJean, Cook, KC, Cristea, IM |
Journal | J Virol |
Volume | 91 |
Issue | 18 |
Date Published | 2017 Sep 15 |
ISSN | 1098-5514 |
Keywords | Eukaryotic Cells, Host-Pathogen Interactions, Organelle Biogenesis, Proteome, Virus Diseases |
Abstract | <p>Viral replication in eukaryotes is a process inherently organized in both space and time. Viral components target subcellular organelles to access host machineries required for replication and spread. Diverse viruses are known to alter organelle shape, composition, function, and dynamics as part of their replication cycles. Here, we highlight recent advances in microscopy and proteomic methods that have helped and will continue to help define mechanisms used by viruses to exploit host proteome organization.</p> |
DOI | 10.1128/JVI.00268-17 |
Alternate Journal | J Virol |
PubMed ID | 28679763 |
PubMed Central ID | PMC5571249 |
Grant List | R01 GM114141 / GM / NIGMS NIH HHS / United States R01 HL127640 / HL / NHLBI NIH HHS / United States T32 GM007388 / GM / NIGMS NIH HHS / United States |