Exploring and Exploiting Proteome Organization during Viral Infection.

TitleExploring and Exploiting Proteome Organization during Viral Infection.
Publication TypeJournal Article
Year of Publication2017
AuthorsBeltran, PMJean, Cook, KC, Cristea, IM
JournalJ Virol
Volume91
Issue18
Date Published2017 09 15
ISSN1098-5514
KeywordsEukaryotic Cells, Host-Pathogen Interactions, Organelle Biogenesis, Proteome, Virus Diseases
Abstract

<p>Viral replication in eukaryotes is a process inherently organized in both space and time. Viral components target subcellular organelles to access host machineries required for replication and spread. Diverse viruses are known to alter organelle shape, composition, function, and dynamics as part of their replication cycles. Here, we highlight recent advances in microscopy and proteomic methods that have helped and will continue to help define mechanisms used by viruses to exploit host proteome organization.</p>

DOI10.1128/JVI.00268-17
Alternate JournalJ Virol
PubMed ID28679763
PubMed Central IDPMC5571249
Grant ListR01 GM114141 / GM / NIGMS NIH HHS / United States
R01 HL127640 / HL / NHLBI NIH HHS / United States
T32 GM007388 / GM / NIGMS NIH HHS / United States