An expeditious synthesis of DPD and boron binding studies.

Publication Year
2005

Type

Journal Article
Abstract

A practical synthesis has been developed for DPD (4,5-dihydroxypentane-2,3-dione), an unstable small molecule that is proposed to be the source of universal signaling agents for quorum sensing in bacteria. The synthesis allows preparation of isotopically labeled DPD and ent-DPD as well as detailed studies of spontaneous binding to borate to give the unusual borate complex 6, the signal for marine bacteria such as Vibrio harveyi. [reaction: see text]

Journal
Org Lett
Volume
7
Issue
4
Pages
569-72
Date Published
2005 Feb 17
ISSN Number
1523-7060
Alternate Journal
Org Lett
PMID
15704896