An expeditious synthesis of DPD and boron binding studies. Author Martin Semmelhack, Shawn Campagna, Michael Federle, Bonnie Bassler Publication Year 2005 Type Journal Article Abstract A practical synthesis has been developed for DPD (4,5-dihydroxypentane-2,3-dione), an unstable small molecule that is proposed to be the source of universal signaling agents for quorum sensing in bacteria. The synthesis allows preparation of isotopically labeled DPD and ent-DPD as well as detailed studies of spontaneous binding to borate to give the unusual borate complex 6, the signal for marine bacteria such as Vibrio harveyi. [reaction: see text] Keywords Vibrio, Bacterial Physiological Phenomena, Ketones, Binding Sites, Signal Transduction, Models, Molecular, Pentanes, Magnetic Resonance Spectroscopy, Boron Journal Org Lett Volume 7 Issue 4 Pages 569-72 Date Published 2005 Feb 17 ISSN Number 1523-7060 DOI 10.1021/ol047695j Alternate Journal Org Lett PMID 15704896 PubMedGoogle ScholarBibTeXEndNote X3 XML