Evolving barcodes shed light into evolving metastases.

TitleEvolving barcodes shed light into evolving metastases.
Publication TypeJournal Article
Year of Publication2021
AuthorsKang, Y, Kuperwasser, C
JournalDev Cell
Volume56
Issue8
Pagination1077-1079
Date Published2021 04 19
ISSN1878-1551
KeywordsBone and Bones, Breast Neoplasms, Female, Humans, Tumor Microenvironment
Abstract

<p>Selective pressure and signals from the tissue microenvironment drive metastasis and determine the survival of metastatic tumor cells at distant organs. Zhang et al. and Bado et al. apply CRISPR-mediated evolving barcode technology to elucidate the role of the bone microenvironment in the evolution of breast cancer metastasis.</p>

DOI10.1016/j.devcel.2021.03.029
Alternate JournalDev Cell
PubMed ID33878297
Grant ListR01 GM124491 / GM / NIGMS NIH HHS / United States