Epithelial-Mesenchymal Plasticity in Cancer Progression and Metastasis.

TitleEpithelial-Mesenchymal Plasticity in Cancer Progression and Metastasis.
Publication TypeJournal Article
Year of Publication2019
AuthorsLu, W, Kang, Y
JournalDev Cell
Date Published2019 May 06
KeywordsAnimals, Cell Plasticity, Cell Transformation, Neoplastic, Embryonic Development, Epithelial-Mesenchymal Transition, Fibroblasts, Humans, Neoplasm Invasiveness, Neoplasm Metastasis, Neoplasms, Neoplastic Stem Cells, Neovascularization, Pathologic

<p>Epithelial-to-mesenchymal transition (EMT) and its reversed process, mesenchymal-to-epithelial transition (MET), are fundamental processes in embryonic development and tissue repair but confer malignant properties to carcinoma cells, including invasive behavior, cancer stem cell activity, and greater resistance to chemotherapy and immunotherapy. Understanding the molecular and cellular basis of EMT provides fundamental insights into the etiology of cancer and may, in the long run, lead to new therapeutic strategies. Here, we discuss the regulatory mechanisms and pathological roles of epithelial-mesenchymal plasticity, with a focus on recent insights into the complexity and dynamics of this phenomenon in cancer.</p>

Alternate JournalDev Cell
PubMed ID31063755
PubMed Central IDPMC6506183
Grant ListR01 CA141062 / CA / NCI NIH HHS / United States
R01 CA212410 / CA / NCI NIH HHS / United States