Epigenetics and Understanding the Impact of Social Determinants of Health.

TitleEpigenetics and Understanding the Impact of Social Determinants of Health.
Publication TypeJournal Article
Year of Publication2015
AuthorsNotterman, DA, Mitchell, C
JournalPediatr Clin North Am
Volume62
Issue5
Pagination1227-40
Date Published2015 Oct
ISSN1557-8240
KeywordsChild, Child, Preschool, Epigenesis, Genetic, Health Status Disparities, Humans, Social Determinants of Health, Telomere
Abstract

<p>Recently, a new research agenda emphasizing interactions between social factors and health has emerged. The term social determinant of health often refers to any nonmedical factor directly influencing health. Health across the life span is strongly and adversely affected by social disadvantage. Research in epigenetics indicates that alterations in DNA methylation may provide a causal link between social adversity and health disparity. Likewise, accelerated loss of telomeres is correlated with chronic stress. Research is still required to develop an understanding of the role of epigenetics and perturbed telomere function in linking social adversity with health outcome.</p>

DOI10.1016/j.pcl.2015.05.012
Alternate JournalPediatr. Clin. North Am.
PubMed ID26318949
PubMed Central IDPMC4555996
Grant ListR01 HD036916 / HD / NICHD NIH HHS / United States
R01 HD076592 / HD / NICHD NIH HHS / United States
R01 HD076592 / HD / NICHD NIH HHS / United States
R01HD36916 / HD / NICHD NIH HHS / United States
R01HD39135 / HD / NICHD NIH HHS / United States
R01HD40421 / HD / NICHD NIH HHS / United States