Title | Epigenetics and Understanding the Impact of Social Determinants of Health. |
Publication Type | Journal Article |
Year of Publication | 2015 |
Authors | Notterman, DA, Mitchell, C |
Journal | Pediatr Clin North Am |
Volume | 62 |
Issue | 5 |
Pagination | 1227-40 |
Date Published | 2015 Oct |
ISSN | 1557-8240 |
Keywords | Child, Child, Preschool, Epigenesis, Genetic, Health Status Disparities, Humans, Social Determinants of Health, Telomere |
Abstract | <p>Recently, a new research agenda emphasizing interactions between social factors and health has emerged. The term social determinant of health often refers to any nonmedical factor directly influencing health. Health across the life span is strongly and adversely affected by social disadvantage. Research in epigenetics indicates that alterations in DNA methylation may provide a causal link between social adversity and health disparity. Likewise, accelerated loss of telomeres is correlated with chronic stress. Research is still required to develop an understanding of the role of epigenetics and perturbed telomere function in linking social adversity with health outcome. </p> |
DOI | 10.1016/j.pcl.2015.05.012 |
Alternate Journal | Pediatr Clin North Am |
PubMed ID | 26318949 |
PubMed Central ID | PMC4555996 |
Grant List | R01HD39135 / HD / NICHD NIH HHS / United States R01 HD039135 / HD / NICHD NIH HHS / United States R01HD36916 / HD / NICHD NIH HHS / United States R01 HD036916 / HD / NICHD NIH HHS / United States P2C HD041028 / HD / NICHD NIH HHS / United States R01HD40421 / HD / NICHD NIH HHS / United States R01 HD076592 / HD / NICHD NIH HHS / United States R01 HD040421 / HD / NICHD NIH HHS / United States |