Enhancer-promoter communication: hubs or loops?

Publication Year
2021

Type

Journal Article
Abstract

There has been a sea change in our view of transcription regulation during the past decade (Fukaya et al., 2016, Lim et al., 2018, Hnisz et al., 2017 [3], Liu et al., 2018 [4], Kato et al., 2012). Classical models of enhancer-promoter interactions and the stepwise assembly of individual RNA Polymerase II (Pol II) complexes have given way to the realization that active transcription foci contain clusters-hubs-of transcriptional activators and Pol II. Here we summarize recent findings pointing to the occurrence of transcription hubs and the implications of such hubs on the regulation of gene activity.

Journal
Curr Opin Genet Dev
Volume
67
Pages
5-9
Date Published
2021 Apr
ISSN Number
1879-0380
Alternate Journal
Curr Opin Genet Dev
PMCID
PMC8653970
PMID
33202367