Enhancer-promoter communication: hubs or loops? Author Bomyi Lim, Michael Levine Publication Year 2021 Type Journal Article Abstract There has been a sea change in our view of transcription regulation during the past decade (Fukaya et al., 2016, Lim et al., 2018, Hnisz et al., 2017 [3], Liu et al., 2018 [4], Kato et al., 2012). Classical models of enhancer-promoter interactions and the stepwise assembly of individual RNA Polymerase II (Pol II) complexes have given way to the realization that active transcription foci contain clusters-hubs-of transcriptional activators and Pol II. Here we summarize recent findings pointing to the occurrence of transcription hubs and the implications of such hubs on the regulation of gene activity. Keywords Promoter Regions, Genetic, Transcription, Genetic, Humans, Transcription Factors, Gene Expression Regulation, Transcriptional Activation, Enhancer Elements, Genetic, RNA Polymerase II Journal Curr Opin Genet Dev Volume 67 Pages 5-9 Date Published 2021 Apr ISSN Number 1879-0380 DOI 10.1016/j.gde.2020.10.001 Alternate Journal Curr Opin Genet Dev PMCID PMC8653970 PMID 33202367 PubMedPubMed CentralGoogle ScholarBibTeXEndNote X3 XML