Enhancer-promoter communication: hubs or loops?

TitleEnhancer-promoter communication: hubs or loops?
Publication TypeJournal Article
Year of Publication2021
AuthorsLim, B, Levine, MS
JournalCurr Opin Genet Dev
Volume67
Pagination5-9
Date Published2021 04
ISSN1879-0380
KeywordsEnhancer Elements, Genetic, Gene Expression Regulation, Humans, Promoter Regions, Genetic, RNA Polymerase II, Transcription Factors, Transcription, Genetic, Transcriptional Activation
Abstract

<p>There has been a sea change in our view of transcription regulation during the past decade (Fukaya et al., 2016, Lim et al., 2018, Hnisz et al., 2017 [3], Liu et al., 2018 [4], Kato et al., 2012). Classical models of enhancer-promoter interactions and the stepwise assembly of individual RNA Polymerase II (Pol II) complexes have given way to the realization that active transcription foci contain clusters-hubs-of transcriptional activators and Pol II. Here we summarize recent findings pointing to the occurrence of transcription hubs and the implications of such hubs on the regulation of gene activity.</p>

DOI10.1016/j.gde.2020.10.001
Alternate JournalCurr Opin Genet Dev
PubMed ID33202367
PubMed Central IDPMC8653970
Grant ListR35 GM118147 / GM / NIGMS NIH HHS / United States
R35 GM133425 / GM / NIGMS NIH HHS / United States