Enhancer-promoter communication: hubs or loops?

TitleEnhancer-promoter communication: hubs or loops?
Publication TypeJournal Article
Year of Publication2021
AuthorsLim, B, Levine, MS
JournalCurr Opin Genet Dev
Date Published2021 04
KeywordsEnhancer Elements, Genetic, Gene Expression Regulation, Humans, Promoter Regions, Genetic, RNA Polymerase II, Transcription Factors, Transcription, Genetic, Transcriptional Activation

<p>There has been a sea change in our view of transcription regulation during the past decade (Fukaya et al., 2016, Lim et al., 2018, Hnisz et al., 2017 [3], Liu et al., 2018 [4], Kato et al., 2012). Classical models of enhancer-promoter interactions and the stepwise assembly of individual RNA Polymerase II (Pol II) complexes have given way to the realization that active transcription foci contain clusters-hubs-of transcriptional activators and Pol II. Here we summarize recent findings pointing to the occurrence of transcription hubs and the implications of such hubs on the regulation of gene activity.</p>

Alternate JournalCurr Opin Genet Dev
PubMed ID33202367
PubMed Central IDPMC8653970
Grant ListR35 GM118147 / GM / NIGMS NIH HHS / United States
R35 GM133425 / GM / NIGMS NIH HHS / United States