Enhanced Zika virus susceptibility of globally invasive populations.

TitleEnhanced Zika virus susceptibility of globally invasive populations.
Publication TypeJournal Article
Year of Publication2020
AuthorsAubry, F, Dabo, S, Manet, C, Filipović, I, Rose, NH, Miot, EF, Martynow, D, Baidaliuk, A, Merkling, SH, Dickson, LB, Crist, AB, Anyango, VO, Romero-Vivas, CM, Vega-Rúa, A, Dusfour, I, Jiolle, D, Paupy, C, Mayanja, MN, Lutwama, JJ, Kohl, A, Duong, V, Ponlawat, A, Sylla, M, Akorli, J, Otoo, S, Lutomiah, J, Sang, R, Mutebi, J-P, Cao-Lormeau, V-M, Jarman, RG, Diagne, CT, Faye, O, Faye, O, Sall, AA, McBride, CS, Montagutelli, X, Rašić, G, Lambrechts, L
JournalScience
Volume370
Issue6519
Pagination991-996
Date Published2020/11/20
ISSN1095-9203
KeywordsAedes, Animals, Host Microbial Interactions, Humans, Mice, Mice, Inbred C57BL, Mosquito Vectors, Zika Virus, Zika Virus Infection
Abstract

The drivers and patterns of zoonotic virus emergence in the human population are poorly understood. The mosquito is a major arbovirus vector native to Africa that invaded most of the world's tropical belt over the past four centuries, after the evolution of a "domestic" form that specialized in biting humans and breeding in water storage containers. Here, we show that human specialization and subsequent spread of out of Africa were accompanied by an increase in its intrinsic ability to acquire and transmit the emerging human pathogen Zika virus. Thus, the recent evolution and global expansion of promoted arbovirus emergence not solely through increased vector-host contact but also as a result of enhanced vector susceptibility.

DOI10.1126/science.abd3663
Alternate JournalScience
PubMed ID33214283
Grant ListMC_UU_12014/8 / MRC_ / Medical Research Council / United Kingdom
R00 DC012069 / DC / NIDCD NIH HHS / United States