|Title||Enhanced Zika virus susceptibility of globally invasive populations.|
|Publication Type||Journal Article|
|Year of Publication||2020|
|Authors||Aubry, F, Dabo, S, Manet, C, Filipović, I, Rose, NH, Miot, EF, Martynow, D, Baidaliuk, A, Merkling, SH, Dickson, LB, Crist, AB, Anyango, VO, Romero-Vivas, CM, Vega-Rúa, A, Dusfour, I, Jiolle, D, Paupy, C, Mayanja, MN, Lutwama, JJ, Kohl, A, Duong, V, Ponlawat, A, Sylla, M, Akorli, J, Otoo, S, Lutomiah, J, Sang, R, Mutebi, J-P, Cao-Lormeau, V-M, Jarman, RG, Diagne, CT, Faye, O, Faye, O, Sall, AA, McBride, CS, Montagutelli, X, Rašić, G, Lambrechts, L|
|Keywords||Aedes, Animals, Host Microbial Interactions, Humans, Mice, Mice, Inbred C57BL, Mosquito Vectors, Zika Virus, Zika Virus Infection|
The drivers and patterns of zoonotic virus emergence in the human population are poorly understood. The mosquito is a major arbovirus vector native to Africa that invaded most of the world's tropical belt over the past four centuries, after the evolution of a "domestic" form that specialized in biting humans and breeding in water storage containers. Here, we show that human specialization and subsequent spread of out of Africa were accompanied by an increase in its intrinsic ability to acquire and transmit the emerging human pathogen Zika virus. Thus, the recent evolution and global expansion of promoted arbovirus emergence not solely through increased vector-host contact but also as a result of enhanced vector susceptibility.
|Grant List||MC_UU_12014/8 / MRC_ / Medical Research Council / United Kingdom |
R00 DC012069 / DC / NIDCD NIH HHS / United States