Engagement of neural circuits underlying 2D spatial navigation in a rodent virtual reality system.

TitleEngagement of neural circuits underlying 2D spatial navigation in a rodent virtual reality system.
Publication TypeJournal Article
Year of Publication2014
AuthorsAronov, D, Tank, DW
JournalNeuron
Volume84
Issue2
Pagination442-56
Date Published2014 Oct 22
ISSN1097-4199
KeywordsAnimals, Computer Simulation, Cues, Hippocampus, Male, Neurons, Orientation, Rats, Long-Evans, Space Perception, Spatial Navigation, User-Computer Interface
Abstract

<p>Virtual reality (VR) enables precise control of an animal's environment and otherwise impossible experimental manipulations. Neural activity in rodents has been studied on virtual 1D tracks. However, 2D navigation imposes additional requirements, such as the processing of head direction and environment boundaries, and it is unknown whether the neural circuits underlying 2D representations can be sufficiently engaged in VR. We implemented a VR setup for rats, including software and large-scale electrophysiology, that supports 2D navigation by allowing rotation and walking in any direction. The entorhinal-hippocampal circuit, including place, head direction, and grid cells, showed 2D activity patterns similar to those in the real world. Furthermore, border cells were observed, and hippocampal remapping was driven by environment shape, suggesting functional processing of virtual boundaries. These results illustrate that 2D spatial representations can be engaged by visual and rotational vestibular stimuli alone and suggest a novel VR tool for studying rat navigation.</p>

DOI10.1016/j.neuron.2014.08.042
Alternate JournalNeuron
PubMed ID25374363
PubMed Central IDPMC4454359
Grant List5R01MH083686 / MH / NIMH NIH HHS / United States
R01 MH083686 / MH / NIMH NIH HHS / United States
5R37NS081242 / NS / NINDS NIH HHS / United States
RC1 NS068148 / NS / NINDS NIH HHS / United States
5RC1NS068148 / NS / NINDS NIH HHS / United States
R37 NS081242 / NS / NINDS NIH HHS / United States