Enclosure of Dendrites by Epidermal Cells Restricts Branching and Permits Coordinated Development of Spatially Overlapping Sensory Neurons.

TitleEnclosure of Dendrites by Epidermal Cells Restricts Branching and Permits Coordinated Development of Spatially Overlapping Sensory Neurons.
Publication TypeJournal Article
Year of Publication2017
AuthorsTenenbaum, CM, Misra, M, Alizzi, RA, Gavis, ER
JournalCell Rep
Volume20
Issue13
Pagination3043-3056
Date Published2017 Sep 26
ISSN2211-1247
KeywordsAnimals, Dendrites, Epidermis, Membrane Proteins, Sensory Receptor Cells
Abstract

<p>Spatial arrangement of different neuron types within a territory is essential to neuronal development and function. How development of different neuron types is coordinated for spatial coexistence is poorly understood. In Drosophila, dendrites of four classes of dendritic arborization (C1-C4da) neurons innervate overlapping receptive fields within the larval epidermis. These dendrites are intermittently enclosed by epidermal cells, with different classes exhibiting varying degrees of enclosure. The role of enclosure in neuronal development and its underlying mechanism remain unknown. We show that the membrane-associated protein Coracle acts in C4da neurons and epidermal cells to locally restrict dendrite branching and outgrowth by promoting enclosure. Loss of C4da neuron enclosure results in excessive branching and growth of C4da neuron dendrites and retraction of C1da neuron dendrites due to local inhibitory interactions between neurons. We propose that enclosure of dendrites by epidermal cells is a developmental mechanism for coordinated innervation of shared receptive fields.</p>

DOI10.1016/j.celrep.2017.09.001
Alternate JournalCell Rep
PubMed ID28954223
PubMed Central IDPMC5662031
Grant ListR01 GM061107 / GM / NIGMS NIH HHS / United States
R01 GM067758 / GM / NIGMS NIH HHS / United States
T32 GM007388 / GM / NIGMS NIH HHS / United States