Emerging strategies for treating metastasis.

TitleEmerging strategies for treating metastasis.
Publication TypeJournal Article
Year of Publication2021
AuthorsEsposito, M, Ganesan, S, Kang, Y
JournalNat Cancer
Volume2
Issue3
Pagination258-270
Date Published2021 Mar
ISSN2662-1347
Abstract

The systemic spread of tumor cells is the ultimate cause of the majority of deaths from cancer, yet few successful therapeutic strategies have emerged to specifically target metastasis. Here we discuss recent advances in our understanding of tumor-intrinsic pathways driving metastatic colonization and therapeutic resistance, as well as immune activating strategies to target metastatic disease. We focus on therapeutically exploitable mechanisms, promising strategies in preclinical and clinical development, and emerging areas with potential to become innovative treatments.

DOI10.1038/s43018-021-00181-0
Alternate JournalNat Cancer
PubMed ID33899000
PubMed Central IDPMC8064405
Grant ListR01 CA212410 / CA / NCI NIH HHS / United States