Emerging Chemistry Strategies for Engineering Native Chromatin.

Publication Year
2017

Type

Journal Article
Abstract

Chromosomes present one of most challenging of all substrates for biochemical study. This is because genomic DNA is physically associated with an astonishing collection of nuclear factors, which serve to not only store the nucleic acid in a stable form, but also grant access to the information it encodes when needed. Understanding this complex molecular choreography is central to the field of epigenetics. One of the great challenges in this area is to move beyond correlative type information, which is now in abundant supply, to the point where we can truly connect the dots at the molecular level. Establishing such causal relationships requires precise manipulation of the covalent structure of chromatin. Tools for this purpose are currently in short supply, creating an opportunity that, as we will argue in this Perspective, is well suited to the sensibilities of the chemist.

Journal
J Am Chem Soc
Volume
139
Issue
27
Pages
9090-9096
Date Published
2017 Jul 12
ISSN Number
1520-5126
Alternate Journal
J Am Chem Soc
PMCID
PMC5752102
PMID
28635271