Title | Dynamic changes in epithelial cell packing during tissue morphogenesis. |
Publication Type | Journal Article |
Year of Publication | 2021 |
Authors | Lemke, SB, Nelson, CM |
Journal | Curr Biol |
Volume | 31 |
Issue | 18 |
Pagination | R1098-R1110 |
Date Published | 2021 09 27 |
ISSN | 1879-0445 |
Keywords | Animals, Cell Shape, Epithelial Cells, Epithelium, Models, Biological, Morphogenesis |
Abstract | <p>Cell packing - the spatial arrangement of cells - determines the shapes of organs. Recently, investigations of organ development in a variety of model organisms have uncovered cellular mechanisms that are used by epithelial tissues to change cell packing, and thereby their shapes, to generate functional architectures. Here, we review these cellular mechanisms across a wide variety of developmental processes in vertebrates and invertebrates and identify a set of common motifs in the morphogenesis toolbox that, in combination, appear to allow any change in tissue shape. We focus on tissue elongation, folding and invagination, and branching. We also highlight how these morphogenetic processes are achieved by cell-shape changes, cell rearrangements, and oriented cell division. Finally, we describe approaches that have the potential to engineer three-dimensional tissues for both basic science and translational purposes. This review provides a framework for future analyses of how tissues are shaped by the dynamics of epithelial cell packing.</p> |
DOI | 10.1016/j.cub.2021.07.078 |
Alternate Journal | Curr Biol |
PubMed ID | 34582821 |
PubMed Central ID | PMC8496771 |
Grant List | R01 HD099030 / HD / NICHD NIH HHS / United States R01 HL120142 / HL / NHLBI NIH HHS / United States U01 CA214292 / CA / NCI NIH HHS / United States / HHMI / Howard Hughes Medical Institute / United States |