Dynamic changes in epithelial cell packing during tissue morphogenesis.

TitleDynamic changes in epithelial cell packing during tissue morphogenesis.
Publication TypeJournal Article
Year of Publication2021
AuthorsLemke, SB, Nelson, CM
JournalCurr Biol
Volume31
Issue18
PaginationR1098-R1110
Date Published2021 Sep 27
ISSN1879-0445
Abstract

<p>Cell packing - the spatial arrangement of cells - determines the shapes of organs. Recently, investigations of organ development in a variety of model organisms have uncovered cellular mechanisms that are used by epithelial tissues to change cell packing, and thereby their shapes, to generate functional architectures. Here, we review these cellular mechanisms across a wide variety of developmental processes in vertebrates and invertebrates and identify a set of common motifs in the morphogenesis toolbox that, in combination, appear to allow any change in tissue shape. We focus on tissue elongation, folding and invagination, and branching. We also highlight how these morphogenetic processes are achieved by cell-shape changes, cell rearrangements, and oriented cell division. Finally, we describe approaches that have the potential to engineer three-dimensional tissues for both basic science and translational purposes. This review provides a framework for future analyses of how tissues are shaped by the dynamics of epithelial cell packing.</p>

DOI10.1016/j.cub.2021.07.078
Alternate JournalCurr Biol
PubMed ID34582821
PubMed Central IDPMC8496771
Grant ListR01 HD099030 / HD / NICHD NIH HHS / United States
R01 HL120142 / HL / NHLBI NIH HHS / United States
U01 CA214292 / CA / NCI NIH HHS / United States