Dog10K: an international sequencing effort to advance studies of canine domestication, phenotypes and health. Author Elaine Ostrander, Guo-Dong Wang, Greger Larson, Bridgett vonHoldt, Brian Davis, Vidhya Jagannathan, Christophe Hitte, Robert Wayne, Ya-Ping Zhang, Dog10K Consortium Publication Year 2019 Type Journal Article Abstract Dogs are the most phenotypically diverse mammalian species, and they possess more known heritable disorders than any other non-human mammal. Efforts to catalog and characterize genetic variation across well-chosen populations of canines are necessary to advance our understanding of their evolutionary history and genetic architecture. To date, no organized effort has been undertaken to sequence the world's canid populations. The Dog10K Consortium (http://www.dog10kgenomes.org) is an international collaboration of researchers from across the globe who will generate 20× whole genomes from 10 000 canids in 5 years. This effort will capture the genetic diversity that underlies the phenotypic and geographical variability of modern canids worldwide. Breeds, village dogs, niche populations and extended pedigrees are currently being sequenced, and assemblies of multiple canids are being constructed. This unprecedented dataset will address the genetic underpinnings of domestication, breed formation, aging, behavior and morphological variation. More generally, this effort will advance our understanding of human and canine health. Journal Natl Sci Rev Volume 6 Issue 4 Pages 810-824 Date Published 2019 Jul ISSN Number 2095-5138 DOI 10.1093/nsr/nwz049 Alternate Journal Natl Sci Rev PMCID PMC6776107 PMID 31598383 PubMedPubMed CentralGoogle ScholarBibTeXEndNote X3 XML