Title | Distinct effects of prefrontal and parietal cortex inactivations on an accumulation of evidence task in the rat. |
Publication Type | Journal Article |
Year of Publication | 2015 |
Authors | Erlich, JC, Brunton, BW, Duan, CA, Hanks, TD, Brody, CD |
Journal | Elife |
Volume | 4 |
Date Published | 2015 Apr 14 |
ISSN | 2050-084X |
Keywords | Animals, Behavior, Animal, Bias, Brain Mapping, Choice Behavior, Male, Models, Neurological, Parietal Lobe, Prefrontal Cortex, Rats, Long-Evans, Task Performance and Analysis |
Abstract | <p>Numerous brain regions have been shown to have neural correlates of gradually accumulating evidence for decision-making, but the causal roles of these regions in decisions driven by accumulation of evidence have yet to be determined. Here, in rats performing an auditory evidence accumulation task, we inactivated the frontal orienting fields (FOF) and posterior parietal cortex (PPC), two rat cortical regions that have neural correlates of accumulating evidence and that have been proposed as central to decision-making. We used a detailed model of the decision process to analyze the effect of inactivations. Inactivation of the FOF induced substantial performance impairments that were quantitatively best described as an impairment in the output pathway of an evidence accumulator with a long integration time constant (>240 ms). In contrast, we found a minimal role for PPC in decisions guided by accumulating auditory evidence, even while finding a strong role for PPC in internally-guided decisions.</p> |
DOI | 10.7554/eLife.05457 |
Alternate Journal | Elife |
PubMed ID | 25869470 |
PubMed Central ID | PMC4392479 |
Grant List | F32 MH098572 / MH / NIMH NIH HHS / United States F32MH098572 / MH / NIMH NIH HHS / United States / / Howard Hughes Medical Institute / United States |