Discovery of Ubonodin, an Antimicrobial Lasso Peptide Active against Members of the Burkholderia cepacia Complex.

Publication Year
2020

Type

Journal Article
Abstract

We report the heterologous expression, structure, and antimicrobial activity of a lasso peptide, ubonodin, encoded in the genome of Burkholderia ubonensis. The topology of ubonodin is unprecedented amongst lasso peptides, with 18 of its 28 amino acids found in the mechanically bonded loop segment. Ubonodin inhibits RNA polymerase in vitro and has potent antimicrobial activity against several pathogenic members of the Burkholderia genus, most notably B. cepacia and B. multivorans, causative agents of lung infections in cystic fibrosis patients.

Journal
Chembiochem
Volume
21
Issue
9
Pages
1335-1340
Date Published
2020 May 04
ISSN Number
1439-7633
Alternate Journal
Chembiochem
PMCID
PMC7205569
PMID
31765515