| Title | Discovery of quorum quenchers targeting the membrane-embedded sensor domain of the receptor histidine kinase, AgrC. |
| Publication Type | Journal Article |
| Year of Publication | 2020 |
| Authors | Xie, Q, Wiedmann, MM, Zhao, A, Pagan, IR, Novick, RP, Suga, H, Muir, TW |
| Journal | Chem Commun (Camb) |
| Volume | 56 |
| Issue | 76 |
| Pagination | 11223-11226 |
| Date Published | 2020 Sep 24 |
| ISSN | 1364-548X |
| Keywords | Bacterial Proteins, Dose-Response Relationship, Drug, Ligands, Microbial Sensitivity Tests, Molecular Conformation, Peptides, Protein Kinases, Quorum Sensing, Staphylococcus aureus |
| Abstract | <p>We combined mRNA display technology with lipid-nanodisc based selections and identified high-affinity ligands targeting the integral membrane sensor domain of the histidine kinase AgrC as potent inhibitors of Staphylococcus aureus quorum sensing-modulated virulence. Our study highlights the potential of this integrated approach for identifying functional modulators of integral membrane proteins.</p> |
| DOI | 10.1039/d0cc04873a |
| Alternate Journal | Chem Commun (Camb) |
| PubMed ID | 32820778 |
| PubMed Central ID | PMC7530097 |
| Grant List | R01 AI042783 / AI / NIAID NIH HHS / United States |
