Discovery of quorum quenchers targeting the membrane-embedded sensor domain of the receptor histidine kinase, AgrC.

TitleDiscovery of quorum quenchers targeting the membrane-embedded sensor domain of the receptor histidine kinase, AgrC.
Publication TypeJournal Article
Year of Publication2020
AuthorsXie, Q, Wiedmann, MM, Zhao, A, Pagan, IR, Novick, RP, Suga, H, Muir, TW
JournalChem Commun (Camb)
Volume56
Issue76
Pagination11223-11226
Date Published2020 Sep 24
ISSN1364-548X
Abstract

<p>We combined mRNA display technology with lipid-nanodisc based selections and identified high-affinity ligands targeting the integral membrane sensor domain of the histidine kinase AgrC as potent inhibitors of Staphylococcus aureus quorum sensing-modulated virulence. Our study highlights the potential of this integrated approach for identifying functional modulators of integral membrane proteins.</p>

DOI10.1039/d0cc04873a
Alternate JournalChem Commun (Camb)
PubMed ID32820778
PubMed Central IDPMC7530097
Grant ListR01 AI042783 / AI / NIAID NIH HHS / United States